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21.
Masoomeh Bayat Avat Arman Taherpour Seyed Mohammad Elahi Thomas Fellowes 《Journal of the Iranian Chemical Society》2018,15(6):1223-1234
Much progress has been made in the treatment of cancer. However, it remains a significant challenge to treat as toxic chemotherapeutic drugs are often poorly tolerated when administered together, limiting the patient’s treatment options. A possible solution to this problem is anchoring drugs on the surface of nanoparticles. These systems have a variety of structures with sizes, shapes and materials which determine loading capacity, cellular targeting and stability. Dendrimers are a class of nanoparticles which have been investigated in this context. In this study, we investigated the functionalization of polyamidoamine (PAMAM) dendrimers with some anticancer medications that suppresses the growth of cancer cells (carmustine, lomustine, semustine and melphalan; 1–4). The possibility of drug release, drug delivery and drug separation by PAMAM was theoretically investigated and discussed. The predicted theoretical method will be interesting to remove the pollutants from the medical solutions by PAMAM dendrimer nanoclusters. The results of the modeling were obtained by MMFF94 and RHF/PM6 methods for all form of the PAMAM–medicines complexes. The obtained results by these two methods were shown same trend of the relative energy surfaces of the complexes of PAMAM–medicines 1–4. 相似文献
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Mitra Ghassemzadeh Mostafa M. Pooramini Maasoomeh Tabatabaee Majid M. Heravi Bernhard Neumüller 《无机化学与普通化学杂志》2004,630(5):625-626
The reaction of 3, 4‐dihydro‐6‐methyl‐3‐thioxo‐1, 2, 4‐triazin‐5(2H)‐one (6‐aza‐2‐thiothymine, AAT, 1 ) with copper(I) chloride in presence of hydrochloric acid in methanol gives the complex [{CuCl2(H2O)2(AT)}2] · 2H2O, 2 , AT = 6‐azathymine) in excellent yield. 2 was characterized by IR spectroscopy and elemental analyses as well as mass spectrometry. Also single‐crystal X‐ray diffraction studies on compound 2 revealed that AT acts as a monodentate ligand in the centrosymmetric binuclear complex via its oxygen atom. Crystal data for 2 at —80 °C: space group P21/c with a = 550.1(1), b = 2712.5(1), c = 729.7(1) pm, β = 95.99(1)°, Z = 2, R1 = 0.0213. 相似文献
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Zarghi A Hajimahdi Z Mohebbi S Rashidi H Mozaffari S Sarraf S Faizi M Tabatabaee SA Shafiee A 《Chemical & pharmaceutical bulletin》2008,56(4):509-512
A new series of 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles was designed and synthesized as anticonvulsant agents. Electroshock and pentylenetetrazole-induced lethal convulsion tests showed that the introduction of an amino group at position 2 of 1,3,4-oxadiazole ring and a fluoro substituent at ortho position of benzyloxy moiety had the best anticonvulsant activity. Our results showed that this effect is mediated through benzodiazepine receptors mechanism. 相似文献
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Mohammadhassan Gholami-Shabani Afshin Imani Masoomeh Shams-Ghahfarokhi Zeynab Gholami-Shabani Arezoo Pazooki Azim Akbarzadeh Gholamhossein Riazi Mehdi Razzaghi-Abyaneh 《Journal of the Iranian Chemical Society》2016,13(11):2059-2068
The development of efficient cell-free systems of nanoparticle synthesis using microbial enzymes is a growing field of biological and green chemistry for the supportable improvement in nano-biotechnology. In the present study, we established a cell-free system for producing gold nanoparticles (AuNPs) using a fungal oxidoreductase named sulfite oxidoreductase purified to homogeneity from Fusarium oxysporum. The enzyme was purified by ultrafiltration followed by anion exchange chromatography on DEAE Sephadex A-50 gel, and its molecular weight was determined by gel filtration chromatography on Sephacryl S-300 gel. The purified enzyme had a molecular weight of 346 kDa. It was composed of three subunits of 176, 94 and 76 kDa. Purified enzyme was successfully used for production of gold nanoparticles in a cell-free system. Synthesized gold nanoparticles showed the highest absorbance at 520 nm wavelength as shown by UV–visible spectroscopy. They were spherical in shape with an average size of 20 nm as determined by scanning and transmission electron microscopy and dynamic light scattering. Assessment of the antifungal properties of synthesized nanoparticles by disk diffusion method indicated a potent growth inhibitory activity against all tested human pathogenic yeasts and molds by inhibition zones ranged from 10 to 18 mm. Taken together, our enzymatically established method of nanoparticle synthesis using a purified sulfite oxidoreductase of F. oxysporum can be considered as an efficient tool for generating harmless bioactive gold nanoparticles with potential applications in biology, medicine and industry. 相似文献
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Abbas Shockravi Shahram Mehdipour-Ataei Masoomeh Zakeri 《European Polymer Journal》2007,43(2):620-627
A new-type of sulfide containing diacid (1,1′-thiobis(2-naphthoxy acetic acid)) was synthesized from 2-naphthol in three steps. Reaction of 2-naphthol with sulfur dichloride afforded 1,1′-thiobis(2-naphthol) (TBN). 1,1′-Thiobis(2-naphthoxy acetic ester) (TBNAE) was successfully synthesized by refluxing the TBN with methylcholoroacetate in the presence of potassium carbonate. The related diacid was synthesized by basic solution reduction of TBNAE. The obtained diacid was fully characterized and used to prepare novel thermally stable poly(sulfide ether amide)s via polyphosphorylation reaction with different aromatic diamines. The properties of these new polyamides were investigated and compared with similar polyamides. These polyamides showed inherent viscosities in the range of 0.39-0.87 dL g−1 in N,N-dimethylacetamide (DMAc) at 30 °C and at a concentration of 0.5 g dL−1. All the polyamides were readily soluble in a variety of polar solvents such as DMAc and tetrahydrofuran (THF). These polyamides showed glass transition temperature (Tg) between 241-268 °C. Thermogravimetric analysis measurement revealed the decomposition temperature at 10% weight loss (T10) ranging from 441- 479 °C in argon atmosphere. 相似文献
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Mohammad M. Mojtahedi M. Saeed Abaee Mehdieh Samianifard Akram Shamloo Masoomeh Padyab A. Wahid Mesbah Klaus Harms 《Ultrasonics sonochemistry》2013,20(3):924-930
Ultrasonic irradiation was efficiently used for high yield synthesis of monoarylidene derivatives of cyclic systems directly from the reaction of ketone with various aldehydes under solvent-free conditions. Reactions took place rapidly in the presence of catalytic amounts of pyrrolidine, while no significant formation of the undesired bis by-products was observed. Moreover, the procedure was applicable to both homo- and heterocyclic ketones. 相似文献