全文获取类型
收费全文 | 1841篇 |
免费 | 39篇 |
国内免费 | 5篇 |
专业分类
化学 | 1361篇 |
晶体学 | 14篇 |
力学 | 23篇 |
综合类 | 1篇 |
数学 | 79篇 |
物理学 | 407篇 |
出版年
2021年 | 9篇 |
2020年 | 9篇 |
2019年 | 19篇 |
2018年 | 11篇 |
2017年 | 10篇 |
2016年 | 17篇 |
2015年 | 33篇 |
2014年 | 30篇 |
2013年 | 78篇 |
2012年 | 72篇 |
2011年 | 97篇 |
2010年 | 50篇 |
2009年 | 37篇 |
2008年 | 93篇 |
2007年 | 111篇 |
2006年 | 96篇 |
2005年 | 80篇 |
2004年 | 76篇 |
2003年 | 78篇 |
2002年 | 84篇 |
2001年 | 54篇 |
2000年 | 46篇 |
1999年 | 23篇 |
1998年 | 16篇 |
1997年 | 12篇 |
1996年 | 21篇 |
1995年 | 13篇 |
1994年 | 24篇 |
1993年 | 24篇 |
1992年 | 26篇 |
1991年 | 26篇 |
1990年 | 24篇 |
1989年 | 17篇 |
1988年 | 23篇 |
1987年 | 31篇 |
1986年 | 25篇 |
1985年 | 35篇 |
1984年 | 23篇 |
1983年 | 16篇 |
1982年 | 22篇 |
1981年 | 22篇 |
1980年 | 22篇 |
1979年 | 29篇 |
1978年 | 26篇 |
1977年 | 24篇 |
1976年 | 24篇 |
1975年 | 30篇 |
1974年 | 25篇 |
1973年 | 20篇 |
1972年 | 10篇 |
排序方式: 共有1885条查询结果,搜索用时 31 毫秒
91.
Hiroyuki Ishibashi Hajime Komatsu Kazumi Maruyama Masazumi Ikeda 《Tetrahedron letters》1985,26(47):5791-5794
A Pummerer rearrangement product, 4-chlorophenylthiomethyl trifluoroacetate (6), obtained from 4-chlorophenyl methyl sulfoxide (5) and trifluoroacetic anhydride, reacted with 1-alkenes in trifluoroacetic acid to give the ene products 8, which were readily converted into the terminal 1,3-dienes 10 by oxidation and subsequent pyrolysis. Using this method, 9,11-dodecadien-1-yl acetate (12), a sex pheromone of the red bollworm moth, was synthesized. 相似文献
92.
Kenjiro Hattori Akira Kenmoku Tsukasa Mizuguchi Daisuke Ikeda Mamoru Mizuno Toshiyuki Inazu 《Journal of inclusion phenomena and macrocyclic chemistry》2006,56(1-2):9-16
A synthetic series of heptakis-galactose-branched cyclodextrins (termed CDs) having a longer spacer arm using two amino-caproic acids as an enlarging unit were prepared. Starting with heptakis-amino-β-CD or heptakis-amino-caproic-amide-β-CD, treated with galactosyl-glucono-amide-caproic acid, the new compounds heptakis (Gal-cap1)-CD (4) or heptakis (Gal-cap2)-CD (5) were obtained. The longer galactose spacer arm extremely favors the PNA association. The effect of branch length on K with PNA was enhanced up to 138-fold 3 as well as with DXR enhanced up to 81-fold. Hexakis (Gal-cap2)-CD (6) was prepared and the association constants with rat liver cells were observed to be 2.5 × 1010 M−1. A multi-high mannose type oligosaccharide branched CD (7) showed a large association constant with DXR up to 1.1 × 109 M−1. The two-dimensional map for the association constants of newly synthesized oligosaccharide-branched CDs toward lectin or liver cells versus the association constants toward a drug (doxorubicin) suggested a method of finding a better targeting drug carrier. The structural effect of the oligosaccharide-CDs showed that the number and length of the branch were dominant factors in designing for enhanced dual recognition. 相似文献
93.
Koji Kano Keisuke Takuma Tsuyoshi Ikeda Daisuke Nakajima Yashuhiro Tsutsui Taku Matsuo 《Photochemistry and photobiology》1978,27(6):695-701
Abstract— Zn-tetraphenylporphyrin (ZnTPP), solubilized in non-ionic surfactant micelles, was found to sensitize photoreductions of some sodium anthraquinonesulfonatesz in the presence of ascorbic acid under anaerobic conditions. The reaction rate was increased by the addition of an anionic surfactant, while retardation was observed with a cationic surfactant. The pH-reaction rate profiles showed maxima located in the order corresponding to pKa-values for the semiquinone of each anthraquinone-sulfonate. A reaction scheme involving the formation of ZnTPP+ at the primary step, followed by back-reduction with ascorbic acid, is proposed. The reaction scheme is in good agreement with the results of flash photolysis. The surfactant micelles are suggested to aid the charge-separation between the ionic species just after the redox reaction involving the photoexcited ZnTPP and anthraquinonesulfonates. 相似文献
94.
95.
96.
Sekino E Kumamoto T Tanaka T Ikeda T Ishikawa T 《The Journal of organic chemistry》2004,69(8):2760-2767
(-)-Quinine-catalyzed intramolecular oxo-Michael addition (IMA) of 7-hydroxy-5-methoxy-8-tigloylcoumarins was developed for the enantioselective construction of 2,3-dimethyl-4-chromanone systems in the context of the asymmetric synthesis of anti-HIV-1 active Calophyllum coumarins. Combination of the IMA and MgI(2)-assisted demethylation of the 5-methoxy group along with isomerization of the formed chromanone systems as key steps successfully led to the concise synthesis of (+)-inophyllum B and (+)-calanolide A, possible candidates for AIDS drugs. Further examination of the asymmetric IMA with cinchona alkaloids lacking a methoxy group on the quinoline skeleton suggested the influence of the methoxy substituent on stereoselectivity at the stereogenic centers of the chromanone systems. 相似文献
97.
[reaction: see text] We describe an efficient synthesis of di-branched heptasaccharide 1 having phytoalexin elicitor activity in soybeans by one-pot glycosylation. The synthesis involves chemo- and regioselective sequential six-step glycosylations using seven independent building blocks and sequential removal of acyl- and benzyl ether-type protecting groups. The coupling of seven building blocks requires only four chemoselective activitable leaving groups of glycosyl donors. Both the glycosylation and deprotection reactions can be achieved utilizing a parallel manual synthesizer. 相似文献
98.
T Ohhashi C Moritani H Andoh S Satoh S Ohmori F Lottspeich M Ikeda 《Journal of chromatography. A》1991,585(1):153-159
A method for the preparative high-yield electroelution of proteins from sodium dodecyl sulphate (SDS) polyacrylamide gel strips was established. The method consisted of SDS-polyacrylamide gel electrophoresis, detection of proteins with sodium acetate and electrophoretic elution at 200 V for 3 h by utilizing a horizontal flat-bed gel electrophoresis apparatus. Standard proteins with molecular masses of 14-66 kilodalton (cytochrome c, aldolase, ovalbumin and bovine serum albumin) were recovered with an average yield of 73.6 +/- 2.3%. A membrane-bound protein, rat skeletal muscle Ca(2+)-ATPase (100 kilodalton) was also well recovered (over 60%). This method was applicable to the purification of proteins required for N-terminal amino acid sequencing and to raise antibodies. 相似文献
99.
The performance of a 160 keV slant hole collimator (160 keV SH) was compared with that of a 140 keV high resolution collimator (140 keV HR) for SPECT imaging of the head using 99mTc. The minimum radius of revolution was reduced from about 23 cm to 13 cm using 160 keV SH. Relative sensitivity of the 160 keV SH was 108% of that of the 140 keV HR. Compared with SPECT using 140 keV HR, 160 keV SH SPECT yielded approximately a 15% increase in resolution. The 160 keV SH SPECT images of phantom were superior in resolution and contrast to that of 140 keV HR SPECT. We concluded that high quality SPECT images of the head can be obtained from rotating gamma cameras equipped with slant hole collimators. 相似文献
100.
Nakamura K Suzuki T Hasegawa M Kato Y Sasaki H Inouye K 《Journal of chromatography. A》2003,1009(1-2):133-139
An affinity sorbent, hydrophilic polymer-based carrier of different pore size (Toyopearl) with immobilized p-aminobenzamidine (ABA), has been prepared. Its basic properties and some applications for protein purification were studied. ABA, which is a synthetic inhibitor for trypsin-like proteases, was covalently immobilized to Toyopearl by reductive amination. The ligand density and binding capacity for porcine trypsin varied depending on the pore size of Toyopearl. The maximum binding capacity of the immobilized p-aminobenzamidine Toyopearl (ABA-Toyopearl) for trypsin was more than 40 mg/ml gel. ABA-Toyopearl thus obtained was very stable below pH 8 and was successfully used for high-performance affinity chromatography of trypsin-like proteases such as trypsin, thrombin, tissue-type plasminogen activator or urokinase in a single step at 25 degrees C. 相似文献