Ultraviolet high-spectral-resolution Rayleigh-Mie lidar with a dual-pass Fabry-Perot etalon for measuring atmospheric temperature profiles of the troposphere

We report what is believed to be the first demonstration of measurement of tropospheric temperature profiles in daytime by use of a high-spectral-resolution Rayleigh-Mie lidar at an eye-safe wavelength of 355 nm. Atmospheric temperature is determined from the linewidth of the Rayleigh spectrum. Two Rayleigh signals are detected with Fabry-Perot etalon filters with a dual-pass optical layout. The Mie signal is detected with a third etalon filter for correcting the Mie component in the Rayleigh signals. The temperature statistical uncertainties are below 1 K up to a height of 3 km in nighttime and 2 km in daytime with a relatively compact system that uses laser energy of 180 mJ and a 25-cm telescope. Good agreement between lidar and radiosonde measurements is obtained.     

Screening of inhibitors of uridine diphosphate glucuronosyltransferase with a miniaturized on-line drug-metabolism system

Inhibition of uridine diphosphate glucuronosyltransferase (UGT), a major drug-metabolyzing enzyme, has been studied using an on-line drug-metabolism system integrated into capillary electrophoresis. Microsomes isolated from rat liver were encapsulated in tetramethoxysilane (TMOS)-based silica matrices within a capillary in a single step under mild conditions. This microsome-immobilized capillary column allows both the metabolism of drugs and determination of the metabolites in a single capillary simultaneously, just by injecting the substrate-coenzyme mixture onto the column. Glucuronidation of acetaminophen, a widely used pharmaceutical analgesic and antipyretic agent, was investigated using this system. The glucuronidation was inhibited by 4-nitrophenol (4NP) or probenecid that was injected onto a column along with the substrate-coenzyme mixture. On the other hand, valproate did not inhibit the metabolizing reaction. The extents of inhibition using encapsulated UGT were almost the same as those obtained using free UGT. On the other hand, this electrophoretic enzyme-inhibitor assay in microfabricated devices consumes 10(4) less sample and 10(3) less microsome per experiment compared to the conventional reaction schemes. These results demonstrate that this on-line system can circumvent laborious procedures for the isolation and determination of drug metabolites from the reaction mixtures required in the conventional schemes and can provide an attractive alternative technique for the analysis of drug interactions in the metabolic pathways.     

Biosynthesis of lambertellols based on the high specific incorporation of the 13C-labeled acetates and their biological properties

Biosyntheses of lambertellols A (1) and B (2) as well as lambertellin (3) were investigated by isotope labeling experiments. Nearly 40% of specific incorporation of [1,2-(13)C(2)]acetate was achieved, and all the carbons in 1 and 2 were labeled. This high incorporation of the labeled acetate was realized by providing INADEQUATE spectra by employing only 0.4 and 0.7 mg of 1 and 2, respectively. Our studies revealed that 1-3 are biogenetically synthesized via loss of two carbons from octameric acetate. A biological assay against Monilinia fructicola revealed those remarkably inhibited hyphal germinations. However, neither of them killed the spores immediately, even in high concentration. These conditions induced the formation of microconidia.     

Highly efficient dye-sensitized solar cells with a titania thin-film electrode composed of a network structure of single-crystal-like TiO2 nanowires made by the "oriented attachment" mechanism

In this study, single-crystal-like anatase TiO(2) nanowires were formed in a network structure by surfactant-assisted self-assembling processes at low temperature. The crystal lattice planes of the nanowires and networks of such wires composed of many nanoparticles were almost perfectly aligned with each other due to the "oriented attachment" mechanism, resulting in the high rate of electron transfer through the TiO(2) nanonetwork with single-crystal-like anatase nanowires. The direction of crystal growth of oriented attachment was controlled by changing the mole ratio of acetylacetone to Ti, that is, regulating both the adsorption of surfactant molecules via control of the reaction rate and the surface energy. A single-crystalline anatase exposing mainly the [101] plane has been prepared, which adsorbed ruthenium dye over 4 times higher as compared to P-25. A high light-to-electricity conversion yield of 9.3% was achieved by applying the titania nanomaterials with network structure as the titania thin film of dye-sensitized solar cells.     

Constraining nuclear equations of state using gravitational waves from hypermassive neutron stars

Latest general relativistic simulations for the merger of binary neutron stars with realistic equations of states (EOSs) show that a hypermassive neutron star of an ellipsoidal figure is formed after the merger if the total mass is smaller than a threshold value which depends on the EOSs. The effective amplitude of quasiperiodic gravitational waves from such hypermassive neutron stars is approximately 6-7 x 10(-21) at a distance of 50 Mpc, which may be large enough for detection by advanced laser interferometric gravitational wave detectors although the frequency is high, approximately 3 kHz. We point out that the detection of such signals may lead to constraining the EOSs for neutron stars.     

Observation of the decay xi0 --> sigma+ mu- nu(mu)

The xi0 muon semileptonic decay has been observed for the first time with nine identified events using the KTeV beam line and detector at Fermilab. The decay is normalized to the xi0 beta decay mode and yields a value for the ratio of decay rates gamma(xi0 --> sigma+ mu- nu(mu))/gamma(xi0 --> sigma+ e- nu(e)) of [1.8(-0.5)(+0.7)(stat) +/- 0.2(syst)] x 10(-2). This is in agreement with the SU(3) flavor symmetric quark model.     

Scale model experiments on noise reduction by acoustic barrier of a straight line source

Noise reduction by an acoustic barrier of a straight line source is examined with the aid of scale model experiments. The line source used in these experiments is an incoherent line source mechanically radiating broad band noise. From the experimental results a curve can be deduced which shows a relation between sound attenuation and Fresnel number N. This curve shows values lower than those of Maekawa's data by 3 ～ 5 dB, which are presented for a point source. On the other hand, it agrees fairly well with Rathe's experimental results, measured near the tracks of a railway line, and also shows a similar tendency to the curve calculated by Kurze and Anderson for an incoherent line source.