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981.
Shinshi M Sugihara T Osakai T Goto M 《Langmuir : the ACS journal of surfaces and colloids》2006,22(13):5937-5944
The transfer of proteins by the anionic surfactant bis(2-ethylhexyl) sulfosuccinate (AOT) at a polarized 1,2-dichloroethane/water (DCE/W) interface was investigated by means of ion-transfer voltammetry. When the tetrapentylammonium salt of AOT was added to the DCE phase, the facilitated transfer of certain proteins, including cytochrome c (Cyt c), ribonuclease A, and protamine, could be controlled electrochemically, and a well-defined anodic wave for the transfer was obtained. At low pH values (e.g., pH 3.4), the anodic wave was usually well-separated from the wave for the formation of protein-free (i.e., unfilled) reverse micelles. The anodic wave for the protein transfer was analyzed by applying the theory for facilitated transfer of ions by charged ligands and then supplying information regarding the number of AOT anions reacting with one protein molecule and the total charge carried by the protein transfer. However, controlled-potential electrolyses performed for the transfer of Cyt c, which is red, revealed that the protein-AOT complexes were unstable in DCE and liable to aggregate at the interface when the pH of the W phase was 3.4. At pH 7.0, when formation of unfilled reverse micelles occurred simultaneously, the protein-AOT complexes appeared to be stabilized, probably via fusion with unfilled reverse micelles. 相似文献
982.
Sueyoshi R Tada K Goto M Tamai N Matsuki H Kaneshina S 《Colloids and surfaces. B, Biointerfaces》2006,50(1):85-88
The phase transition between the lamellar liquid crystal (Lalpha) phase and the inverted hexagonal (H(II)) phase of dioleoylphosphatidylethanolamine (DOPE) in aqueous NaCl solutions was observed by means of differential scanning calorimetry (DSC) under ambient pressure and light-transmittance technique under high pressure. The pressure dependence of the transition temperature (dT/dp) and the thermodynamic quantities for the Lalpha/H(II) transition were compared with those of another phase transition found in the DOPE bilayer membrane, which is the transition from the lamellar crystal (Lc) phase to the Lalpha phase. The dT/dp value of the Lalpha/H(II) transition was about 3.5 times as large as that of the Lc/Lalpha transition while the thermodynamic quantities were significantly smaller than those of the latter to the contrary. Comparing the enthalpy and volume behavior of the Lalpha/H(II) transition with that of the Lc/Lalpha transition, we concluded that the Lalpha/H(II) transition can be regarded as the volume-controlled transition for the reconstruction of molecular packing. 相似文献
983.
The crystal structures and photochromic performance of a single crystal of a diarylethene derivative possessing carboxyl groups, 1,2-bis(5-carboxyl-2-methyl-3-thienyl)perfluorocyclopentene (1 a), and cocrystals of 1 a with 4,4'-, 2,4'-, and 2,2'-bipyridines were examined. In crystal 1 a, a discrete cyclic structure was observed, in which four 1 a molecules are linked through hydrogen bonds between the carboxyl groups. In the homocrystal, photoreactive and photoinactive conformers of 1 a exist in the ratio of 1:1. In the cocrystals of 1 a with bipyridines, O--HN-type hydrogen bonds between 1 a and pyridyl groups were formed, and all 1 a molecules are fixed in a photoreactive conformation. Both the homocrystal 1 a and the cocrystals showed photochromic performances, and color variation from bluish-violet to cyan was observed, depending on the conformation of the packed diarylethene molecules. 相似文献
984.
Kobayashi J Goto K Kawashima T Schmidt MW Nagase S 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(14):3811-3820
The reaction behavior of 1-hydro-5-carbaphosphatrane (1 a) was examined. Treatment of 1 a with oxidants such as 3-chloroperoxybenzoic acid (mCPBA) and tBuOCl gave cyclic phosphonate 2 and 1-chloro-5-carbaphosphatrane (4), respectively, via cyclic phosphonite 3, a tautomer of 1 a. Compound 4 was readily hydrolyzed to afford 2. Compound 1 a was also sulfurized via 3 by elemental sulfur to afford cyclic thioxophosphonate 5, which was also obtained by reactions in the presence of bases. Treatment of 1 a with bases also proceeded through 3 to give an equilibrium mixture of the corresponding phenoxide anion 10 and the phosphoranide anion 9, which was quenched with MeI to afford a mixture of 11 and 1-methyl-5-carbaphosphatrane (1 b). Such reactivities are typical for neutral phosphoranes. Theoretical investigations of these reactivities were also performed. 相似文献
985.
Hirata Y Nakamura S Watanabe N Kataoka O Kurosaki T Anada M Kitagaki S Shiro M Hashimoto S 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(35):8898-8925
A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids A and C is described. The carbonyl ylide precursor 8 was synthesized starting from di-tert-butyl D-tartrate (47) via an eleven-step sequence involving the regioselective reduction of the mono-MPM (MPM=4-methoxybenzyl) ether 48 with LiBH4 and the diastereoselective addition of sodium tert-butyl diazoacetate to alpha-keto ester 10. The reaction of alpha-diazo ester 8 with 3-butyn-2-one (40) in the presence of a catalytic amount of [Rh2(OAc)4] gave the desired cycloadduct 59 as a single diastereomer. The dihydroxylation of enone 59 followed by sequential transformations permitted the construction of the fully functionalized 2,8-dioxabicyclo[3.2.1]octane core 5. Alkene 79 derived from 5 serves as a common precursor to zaragozic acids A (1) and C (2), since the elongation of the C1 alkyl side chain can be attained by olefin cross-metathesis, especially under the influence of Blechert's catalyst (85). 相似文献
986.
Kakiyama G Hosoda A Iida T Fujimoto Y Goto T Mano N Goto J Nambara T 《Journal of chromatography. A》2006,1125(1):112-116
A direct method for the separation and quantification of a series of bile acid acyl glycosides using high-performance liquid chromatography coupled to an evaporative light scattering detector (HPLC-ELSD) is described. Complete separation of each of 15 bile acid acyl 24-alpha-glucosides and their 24-beta-anomers and 24-beta-galactosides was achieved by the stepwise gradient elution mode on a C18 column using a mixture of acetonitrile-methanol (8:2, v/v) and 1% aqueous acetic acid as the mobile phase. 24-beta-Galactosides were always eluted faster than the corresponding 24-beta-glucosides, which eluted after the corresponding 24-alpha-anomers. Calibration curves of different 24-beta-galactosides were linear over a range of 0.2-40 nmol of injected amount and the detection limits (S/N > 3) were from 0.08 to 0.1 nmol. The present HPLC-ELSD method may provide an insight into the separation and quantification of the biologically interesting neutral bile acids. 相似文献
987.
Kato S Matsumoto T Ideta K Shimasaki T Goto K Shinmyozu T 《The Journal of organic chemistry》2006,71(13):4723-4733
This paper reports the electroscopic and electrochemical properties of [2 + 2] pyromellitic diimide-based cyclophane 1 as well as acyclic N,N'-bis(2-methoxybenzyl)pyromellitic diimide 2 and the clathrate compounds formed by 1. Compound 1 was synthesized by direct cyclocondensation. Its structure was determined by an X-ray crystallographic analysis of a single crystal obtained by recrystallization from DMF. The intramolecular charge-transfer interactions of 1 and 2 were characterized by UV/vis spectroscopy and MO calculations. The UV/vis spectra showed that the tail of a longer wavelength absorption of both 1 and 2 reached the visible region. MO calculations (B3LYP/6-31G*) showed that the HOMO and LUMO orbitals of 1 and 2 substantially localize in the xylyl and pyromellitic diimide moieties across the methylene linker, respectively. The X-ray crystallographic analyses demonstrated that single crystals grown from a mixture of 1 and alpha-naphthol and a mixture of 1 and beta-naphthol were the clathrate compounds with 1D and 2D supramolecular assemblies, respectively, which are formed by a combination of hydrogen-bonding and charge-transfer interactions. From the cyclic voltammetry measurements, both 1 and 2 showed reversible reduction processes, and the reduction potential observed at -1.09 V vs Ag/Ag+ for 2 split into two potentials at -1.01 and -1.14 V for 1. The addition of alpha- and beta-naphthol induced a decrease in the potentials due to the diradical anion of 1 and radical anion of 2 by about 80 mV, and their reduction processes were reversible. 相似文献
988.
The 9-methyl group of 11-cis retinal is important in the efficient formation of the active conformation of rhodopsin, Meta II. Here, Tyrl91 rhodopsin mutants were generated because of its proximity to that methyl group in the dark structure. If photoactivation results in movement of the 9-methyl group toward Tyrl91, the steric interactions involved with activation and/or deactivation might not be as tightly coupled in mutant proteins with smaller amino acids at that position. Tyrl91 mutations have no effect on the dark pigment. However, after photobleaching, the lifetime of Meta II is shorter; Meta II decays quickly into two inactive species: (1) a Meta III or Meta III-like species and (2) opsin and free retinal. The Meta III-like fraction maintains the covalent Schiff base linkage of the chromophore much longer than the wild type. On the other hand, the fast chromophore release is similar to cone pigments. Taken together, the data suggest that the role of the 9-methyl group after photo-isomerization is not only to form Meta II efficiently, but also to maintain its active conformation and allow for the timely hydrolysis of the Schiff base. Perturbation of this interaction effects changes in the hydrolysis of the Schiff base and for the case of the Y191A mutation the folded structure of the protein after photobleaching. 相似文献
989.
Yellowish S-containing TiO2 (S-TiO2) powders were prepared by calcination of a mixture of titanium(III) chloride and ammonium thiocyanate solutions. Three kinds of S-TiO2 were prepared by varying the concentration of ammonium thiocyanate (0.5, 1 or 13 M). X-ray photoelectron spectroscopy spectra of the S-TiO2 showed that sulfur atoms existed on the surface of TiO2 powders. But the peaks assigned to S disappeared after Ar+ etching, which means that these atoms were not doped in the bulk of the TiO2 powders. While UV-visible absorption spectra of S-TiO2 showed that the absorption edges of these photocatalysts were seen to shift to a longer wavelength (lower band gap energy) than those of undoped rutile TiO2 prepared and commercial anatase type TiO2 (ST-01). The S-TiO2 (1 M) exhibited higher photocatalytic activity than ST-01 for degradation of methylene blue in aqueous solution under visible light irradiation (lambda > 400 nm). It was also confirmed by IR spectroscopy that acetaldehyde in oxygen under visible light irradiation (lambda > 400 nm) was decomposed to acetic acid by the S-TiO2 and ST-01 at the first decomposition step. 相似文献
990.
Synthetic study for two 2H‐chromenic acids, 8‐chlorocannabiorcichromenic acid and mycochromenic acid
Seiji Yamaguchi Masahiro Nedachi Mikiko Maekawa Yohei Murayama Masahiro Miyazawa Yoshiro Hirai 《Journal of heterocyclic chemistry》2006,43(1):29-41
Two 2H‐chromenes having a fully substituted benzene ring, 8‐chlorocannabiorcichromene ( 1 ) and mycochromenic acid ( 2 ), were synthesized by a condensation of salicylaldehydes with isopropylidenemalonate or the thermal cyclization of corresponding propargyl ethers. 相似文献