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We present some general properties of solutions of an equation which appeared in a problem posed by Z. Boros and Z. Daróczy. Using them we solve this equation in some classes of functions assuming regularity of solutions. We also present some facts concerning regular solutions of two related equations.  相似文献   
64.
The paper proposes an engineering approach for the replacement of beam-like structures and joints in a vehicle model. The final goal is to provide the designer with an effective methodology for creating a concept model of such automotive components, so that an NVH optimization of the body in white (BIW) can be performed at the earliest phases of the vehicle design process. The proposed replacement methodology is based on the reduced beam and joint modelling approach, which involves a geometric analysis of beam-member cross-sections and a static analysis of joints. The first analysis aims at identifying the beam center nodes and computing the equivalent beam properties. The second analysis produces a simplified model of a joint that connects three or more beam-members through a static reduction of the detailed joint FE model.In order to validate the proposed approach, an industrial case-study is presented, where beams and joints of the upper region of a vehicle's BIW are replaced by simplified models. Two static load-cases are defined to compare the original and the simplified model by evaluating the stiffness of the full vehicle under torsion and bending in accordance with the standards used by automotive original equipment manufacturer (OEM) companies. A dynamic comparison between the two models, based on global frequencies and modal shapes of the full vehicle, is presented as well.  相似文献   
65.
Herein, we provide a systematic theoretical and experimental study of the structural and optical properties of MMX (M=metal, X=halide) chains. The influence of solvent, temperature, and concentration has been analyzed to find suitable parameters for initial building‐block associations in solution. By using density functional calculations, we have computed the dissociation energy of different MMX oligomers (up to the tetramer) in the gas phase. On the basis of these findings, we discuss the most likely disassembly scenario and propose a new interpretation of these compounds. We also calculated the charge redistribution that occurs upon MM+XMMX binding in vacuum. Time‐dependent density functional theory (TDDFT) is used to calculate the UV/visible spectra of different MMX chains up to the tetramer in the gas phase. The implications of these theoretical findings in the analysis of our experiments are discussed in the text. The overall body of data presented suggests a new way of looking at such linear structures. By taking into account these new data, we have been able to isolate single/few MMX chains on mica.  相似文献   
66.
Summary The estimation of the Re concentration factor (CF) has been carried out to provide additional field information on the biochemical similarities between Re and Tc. Re concentration in brown seaweed samples from the North Atlantic Coast were measured using ID-ICP-MS. The chemical yields were quantitative, and the concentrations were distributed within a narrow range of 65-80 ng/g d.w. CF of Re was approximately 1.2 . 104 on average, i.e., one order of magnitude less than that found for 99Tc.  相似文献   
67.
Water quality assessment requires a continuous and strict analysis of samples to guarantee compliance with established standards. Nowadays, the increasing number of pollutants and their synergistic effects lead to the development general toxicity bioassays capable to analyse water pollution as a whole. Current general toxicity methods, e.g. Microtox®, rely on long operation protocols, the use of complex and expensive instrumentation and sample pre-treatment, which should be transported to the laboratory for analysis. These requirements delay sample analysis and hence, the response to avoid an environmental catastrophe. In an attempt to solve it, a fast (15 min) and low-cost toxicity bioassay based on the chromatic changes associated to bacterial ferricyanide reduction is here presented. E. coli cells (used as model bacteria) were stably trapped on low-cost paper matrices (cellulose-based paper discs, PDs) and remained viable for long times (1 month at −20 °C). Apart from bacterial carrier, paper matrices also acted as a fluidic element, allowing fluid management without the need of external pumps. Bioassay evaluation was performed using copper as model toxic agent. Chromatic changes associated to bacterial ferricyanide reduction were determined by three different transduction methods, i.e. (i) optical reflectometry (as reference method), (ii) image analysis and (iii) visual inspection. In all cases, bioassay results (in terms of half maximal effective concentrations, EC50) were in agreement with already reported data, confirming the good performance of the bioassay. The validation of the bioassay was performed by analysis of real samples from natural sources, which were analysed and compared with a reference method (i.e. Microtox). Obtained results showed agreement for about 70% of toxic samples and 80% of non-toxic samples, which may validate the use of this simple and quick protocol in the determination of general toxicity. The minimum instrumentation requirements and the simplicity of the bioassay open the possibility of in-situ water toxicity assessment with a fast and low-cost protocol.  相似文献   
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In this work, we present the application of a fast and sensitive microanalytical method, microchip capillary electrophoresis (MCE), for the determination of NO2 and NO3 ions in deionized water treated by atmospheric pressure plasma jet (APPJ). The MCE technique consisted of an online combination of isotachophoresis with zone electrophoresis, both performed on the microchip. The argon plasma has been characterized by optical emission spectroscopy (OES) and Fourier transform infrared spectroscopy (FTIR). OES confirmed the presence of argon excited species (Ar I) emission (4p4s) lines, N2 emission bands (second positive system C3Πu → B3Πg), and OH band (A2+ → X2Π Δv = 0), as well as the presence of NO and excited NO2. The presence of NO2 molecules was also confirmed by FTIR absorption spectroscopy. The performance of the developed MCE method was evaluated for linearity, limit of detection, limit of quantitation, precision, and accuracy, and the concentration of NO2 and NO3 in the water as a function of the water treatment time was monitored.  相似文献   
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Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading cause of cancer death. According to the Malaysian National Cancer Registry Report 2012–2016, colorectal cancer was the second most common cancer in Malaysia after breast cancer. Recent treatments for colon cancer cases have caused side effects and recurrence in patients. One of the alternative ways to fight cancer is by using natural products. Curcumin is a compound of the rhizomes of Curcuma longa that possesses a broad range of pharmacological activities. Curcumin has been studied for decades but due to its low bioavailability, its usage as a therapeutic agent has been compromised. This has led to the development of a chemically synthesized curcuminoid analogue, (2E,6E)-2,6-bis(2,3-dimethoxybenzylidine) cyclohexanone (DMCH), to overcome the drawbacks. This study aims to examine the potential of DMCH for cytotoxicity, apoptosis induction, and activation of apoptosis-related proteins on the colon cancer cell lines HT29 and SW620. The cytotoxic activity of DMCH was evaluated using the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) cell viability assay on both of the cell lines, HT29 and SW620. To determine the mode of cell death, an acridine orange/propidium iodide (AO/PI) assay was conducted, followed by Annexin V/FITC, cell cycle analysis, and JC-1 assay using a flow cytometer. A proteome profiler angiogenesis assay was conducted to determine the protein expression. The inhibitory concentration (IC50) of DMCH in SW620 and HT29 was 7.50 ± 1.19 and 9.80 ± 0.55 µg/mL, respectively. The treated cells displayed morphological features characteristic of apoptosis. The flow cytometry analysis confirmed that DMCH induced apoptosis as shown by an increase in the sub-G0/G1 population and an increase in the early apoptosis and late apoptosis populations compared with untreated cells. A higher number of apoptotic cells were observed on treated SW620 cells as compared to HT29 cells. Human apoptosis proteome profiler analysis revealed upregulation of Bax and Bad proteins and downregulation of Livin proteins in both the HT29 and SW620 cell lines. Collectively, DMCH induced cell death via apoptosis, and the effect was more pronounced on SW620 metastatic colon cancer cells, suggesting its potential effects as an antimetastatic agent targeting colon cancer cells.  相似文献   
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Summary The ionic behaviour of 1-phenyl-3-pyrazolidinone (phenidone) at different pH values and its complexes with a selected group of metal ions such as Mg(II), Al(III), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) were investigated in the pH range of 1–13 by paper electrophoresis. pH-mobility curves were determined for phenidone, the nine metal ions and 21 metal-ligand systems with 1, 110 and 1100 metal: ligand ratios. The effect of the pH on complex formation and the influence of the phenidone concentration on the metal ion mobilities are discussed.Presented at the XXII International Conference on Coordination Chemistry, August 23–27, 1982, Budapest (Hungary).  相似文献   
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