Determination of 11 Cannabinoids in Hemp Plant and Oils by Liquid Chromatography and Photodiode Array Detection

Chromatographia - Drug scheduling has directed the testing approaches for forensic laboratories since the 1970s when Cannabis (marijuana and hemp) and its psychoactive constituent,...     

Solvent-free one-pot synthesis of 4-aryl-3,5-dimethyl-1,4,7,8-tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridines using Fe3O4@SiO2@(BuSO3H)3 catalytic Fe3+ system as selective colorimetric

Research on Chemical Intermediates - The synthesis of 4-Aryl-(3,5-dimethyl-1,4,7,8-tetrahydro-dipyrazolo[3,4b:4′,3′e]pyridine derivatives was accomplished using Fe3O4@SiO2@(BuSO3H)3...     

Theoretical investigation of adsorption of the gabapentin drug on the heteroborospherene

Structural Chemistry - This is an analysis report on the use of density functional theory (DFT) to investigate the potentials of pristine and amino acid–functionalized C4B32 borospherenes in...     

Methyl Methacrylate–Ethyleneglycol Dimethacrylate–Acrylic Acid Surface as Stationary Phase for Stir Bar Sorptive Extraction

A novel poly(methyl methacrylate–ethyleneglycol dimethacrylate–acrylic acid) film has been introduced for coating on stir bars to sorptive extraction (SBSE). The effects of different contents of porogen, monomer, cross-linker, modifier and initiator during the solvent or bulk polymerization step on the mechanical property and solvent resistant of prepared sorptive stir bars were investigated. The evaluation of results were caused to obtain the four prepared sorptive stir bars with good mechanical stability and excellent resistance to organic solvents. The extraction efficiency of these prepared sorptive stir bars were investigated by liquid desorption-liquid chromatography-ultraviolet detection (LD-LC-UV) using N-Nitrosodiphenylamine as target analyte. SBSE assays showed the sorptive stir bar that prepared using solution polymerization method had the better recovery for N-Nitrosodiphenylamine in water samples. This sorptive stir bar showed good linearity and acceptable recoveries, as well as advantages such as sensitivity, simplicity, low cost and high feasibility. Based on atomic force microscopy (AFM) results, the average pore size of optimum prepared stir bar using solvent polymerization method was obtained ~9 nm. The thermal gravity (TG) and differential scanning calorimetric (DSC) results showed this polyacrylate film has high thermal stability.     

Sorted cell microarrays as platforms for high-content informational bioassays

We report on surface-engineered microarrays that provide in situ cell sorting, localization, and immobilization of various subsets of human primary lymphocytes, followed by an on-chip bioassay for ionizing-radiation-induced cytogenetic damage. The microarray format eliminates the necessity of separating cell sub-populations by alternative means (such as fluorescence- or magnetic-activated cell sorting) prior to performing informational bioassays. To exemplify the potential of this on-chip cytometry approach, we have integrated the cytokinesis-block micronucleus cytome (CBMNcyt) assay with the microarray platform for analysis of the chromosome damage profile of specific subsets of human peripheral lymphocytes. Microarray results were compared with data obtained from the traditional CBMNcyt assay on heterogeneous lymphocyte populations, and with flow cytometry data. Our results suggest that cytogenetic damage caused by ionizing radiation is not uniformly distributed across all lymphocytes subsets, but rather concentrated in specific subsets. The salient features of our approach are that it requires very small volumes of reagents, allows sorting of lymphocyte subsets in situ, increases parallelism of cell assays and is amenable to high content microscopy analysis. The on-chip cytometry format opens new vistas for advanced cell-based assays, potentially bringing to light important information which remains hidden with conventional assays and hence engendering new discoveries in cell biology.     

NiO nanoparticles prepared via thermal decomposition of the bis(dimethylglyoximato)nickel(II) complex: A novel reusable heterogeneous catalyst for fast and efficient microwave-assisted reduction of nitroarenes with ethanol

NiO nanoparticles with an average size of 12 nm and a high specific surface area of 88.5 m²/g were easily prepared via the thermal decomposition of the complex Ni(dmgH)₂ and were characterized by TGA, XRD, FT-IR, TEM and BET surface area measurement. This nanosized transition metal oxide was used as a new heterogeneous catalyst for the reduction of nitroarenes under microwave irradiation. The efficient and selective reduction of aromatic nitro compounds into their corresponding amines was observed by using ethanol as a hydrogen donor (reducing agent) and KOH as a promoter under microwave irradiation. This highly regio- and chemoselective method is fast, simple, inexpensive, high yielding, clean and compatible with several sensitive functionalities, such as halogens, -OH, -OCH₃, -CHO, -COCH₃, -COOH, -COOEt, -CONH₂, -CN, -CHCH₂ and -NHCOCH₃. This method is suitable for the large scale preparation of different substituted anilines as well as other arylamines. In addition, the catalytic activity of nanosized NiO is higher than that of the bulk sample.     

A new solid phase micro extraction for simultaneous head space extraction of ultra traces of polar and non-polar compounds

The results of the innovative study on a new stationary phase with high efficiency based on ZnO nano and micro rod coating on fused silica are reported in this paper. ZnO nanorods with a diameter in the range of 70–300 nm and the length of about 500 nm, have been grown on fused silica fibers using a hydrothermal process. The extraction properties of the fiber were investigated using headspace solid-phase microextraction (HS-SPME) mode coupled with gas chromatography–mass spectrometry detection (GC–MS) for 1,4-dichloro-nitrobenzene, biphenyl and acenaphthene. The calibration curves were linear up to 10²–10⁷ ng L⁻¹ (R² > 0.995) with detection limits of 10⁻³ ng L⁻¹ for biphenyl and acenaphthene and 10 ng L⁻¹ for 1,4-dichloro-nitrobenzene. The RSD for single fiber and fiber-to-fiber were less than 7.0 and 11.5%, respectively. The high stability of the ZnO coating is proved at relatively high temperatures (up to 300 °C) with a high extraction capacity and long lifespan (more than 100 times). Promising recoveries (91–102%) were obtained in environmental water samples analysis by applying the proposed technique.