The reactions of azidopyrazole with some of primary amines and active methylene compounds were studied. Structures of the prepared compounds were identified using spectroscopic techniques. The reactions mechanisms were also proposed. The cytotoxic and antimicrobial activities were also examined for the newly synthesized compounds. 相似文献
MgH(2) has too high an operating temperature for many hydrogen storage applications. However, MgH(2) ball-milled with Ge leads to a thermodynamic destabilisation of >50 kJ mol(-1)(H(2)). This has dramatically reduced the temperature of dehydrogenation to 130 °C, opening up the potential for Mg-based multicomponent systems as hydrogen stores for a range of applications. 相似文献
The heterocyclic hydrazones constitute an important class of biologically active drug molecules. The hydrazones have also
been used as herbicides, insecticides, nematocides, redenticides, and plant growth regulators as well as plasticizers and
stabilizers for polymers. The importance of the phenolic quinolyl hydrazones arises from incorporating the quinoline ring
with the phenolic compound; 2,4-dihydroxy benzaldehyde. Quinoline ring has therapeutic and biological activities whereas,
phenols have antiseptic and disinfectants activities and are used in the preparation of dyes, bakelite and drugs. The present
study is planned to check the effect of the counter anions on the type and geometry of the isolated copper(II)- complexes
as well as the ligational behavior of the phenolic hydrazone; 4-[(2-(4,8-dimethylquinolin-2-yl)hydrazono)methyl] benzene-1,3-diol;
(H2L). 相似文献
The inclusion behavior of an intramolecular charge transfer (ICT) fluorescent probe namely; 2-[3-(4-dimethylamino-phenyl)-allylidene]-tetralone (DMAPT) in organized assemblies of aqueous micellar, α- and β-cyclodextrins (CDs) and bovine serum albumin (BSA) pockets have been studied using steady-state absorption and fluorescence spectroscopy. The fluorescence characteristics (energy and intensity) of DMAPT are highly sensitive to the properties of the medium. The ICT maximum is strongly blue-shifted with a great enhancement of the fluorescence intensity upon addition of different surfactants, confirming the solubilization of DMAPT in the hydrophobic micellar assembly. In addition, the fluorescence of DMAPT is more sensitive to the nature and concentration of the added CDs. In α- or β-CD solutions, the fluorescence intensity increases strongly (by 6 and 23 orders of magnitude, respectively). Upon encapsulation in the CD cavity, the molecular flexibility decreases due to the geometrical restrictions of the CD nanocavity which decreases the non radiative transition via the free rotation around the single and/or double bonds of the butadiene bridge. This was supported by finding that the fluorescence quantum yield of DMAPT increases with increasing the viscosity of the medium. The binding constants of DMAPT with micelles, α- and β-CD solutions have been calculated and were found to be highly dependent on the nature of the used surfactants or CDs. The thermodynamic parameters have been also determined and the difference in magnitude between the formed α- and β-CD-DMAPT inclusion complexes is discussed on the basis of the cavity size. Finally, the binding constant of DMAPT with bovine serum albumin was calculated, indicating the relative stability of the DMAPT-BSA complex. The energy transfer distance between BSA as a donor and DMAPT as an acceptor was obtained following the fluorescence quenching of BSA by DMAPT, via resonance mechanism as a quencher. 相似文献
In this work, different pretreatment methods for algae proved to be very effective in improving cell wall dissociation for biogas production. In this study, the Ulva intestinalis Linnaeus (U. intestinalis) has been exposed to individual pretreatments of (ultrasonic, ozone, microwave, and green synthesized Fe3O4) and in a combination of the first three mentioned pretreatments methods with magnetite (Fe3O4) NPs, (ultrasonic-Fe3O4, ozone-Fe3O4 and microwave-Fe3O4) in different treatment times. Moreover, the green synthesized Fe3O4 NPs has been confirmed by FTIR, TEM, XRD, SEM, EDEX, PSA and BET. The maximum biogas production of 179 and 206 mL/g VS have been attained when U. intestinalis has been treated with ultrasonic only and when combined microwave with Fe3O4 respectively, where sediment were used as inoculum in all pretreatments. From the obtained results, green Fe3O4 NPs enhanced the microwave (MW) treatment to produce a higher biogas yield (206 mL/g VS) when compared with individual MW (84 mL/g VS). The modified Gompertz model (R2 = 0.996 was appropriate model to match the calculated biogas production and could be used more practically to distinguish the kinetics of the anaerobic digestion (AD) period. The assessment of XRD, SEM and FTIR discovered the influence of different treatment techniques on the cell wall structure of U. intestinalis. 相似文献
Abstract The reaction of 1-[4-(piperidin-1-yl)benzylidene]thiosemicarbazide with hydrazonoyl chlorides afforded 1,3-thiazole derivatives.
Cyclization of two compounds of the latter 1,3-thiazole by means of bromine in the presence of sodium acetate at room temperature
gave 1,3-thiazolo[2,3-c]-1,2,4-triazole derivatives. The reaction of 2-cyano-3-(4-piperidin-1-ylphenyl)prop-2-enethioamide with hydrazonoyl chlorides
under reflux in ethanol in the presence of triethylamine yielded 1,3-thiazoles. Treatment of 3-oxo-3-(piperidin-1-yl)propanenitrile
with phenyl isothiocyanate in DMF, in the presence of KOH, at ambient temperature, resulted in the formation of 3-anilino-3-mercapto-2-(piperidin-1-ylcarbonyl)acrylonitrile
which was reacted with hydrazonoyl chlorides to yield the corresponding 1,3,4-thiadiazole derivatives. Some of the newly synthesized
compounds had significant anti-arrhythmic activity.
Graphical Abstract
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Abstract 5-Aminobenzo[b]thiophene-2-carboxylic acid was converted to the corresponding 5-(2-chloroacetamido)benzo[b]thiophene-2-carboxylic acid by reaction with chloroacetyl chloride. This acetamido product was treated with different alkyl,
cycloalkyl, aryl, and heterocyclic amines to afford a series of C5-substituted benzo[b]thiophenes. These compounds were found to possess potent anti-inflammatory activity.
Graphical abstract
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In this work, two newly sensitive and selective Al(III)-modified carbon paste electrodes (MCPEs) were developed based on diphenylcarbazone (DPC) modifier mixed with tricresyl phosphate plasticizer and either graphite powder (electrode I) or graphite powder mixed with graphene (electrode II). The potentiometric performance characteristics of the two electrodes were scrutinized and discussed. The proposed sensors showed a high electrochemical response in the linear concentration range of 1.0 × 10−6 to 1.0 × 10−2 mol L−1 with a good Nernstian slopes of 20.12 ± 0.30 mV decade−1 and 20.63 ± 0.66 mV decade−1 and limits of detection of 9.0 × 10−7 and 8.5 × 10−7 mol L−1 for electrode (I) and electrode (II), respectively. Both electrodes showed a fast response time and reasonable thermal stability. The potentiometric response of the DPC-based electrodes was independent on the pH of the tested solutions in ranges of 2.5–5 and 2.5–5.5 for electrode (I) and electrode (II), respectively. The two electrodes can be also used in partially non-aqueous medium containing up to 20% (v/v) acetone or methanol with no significant changes in the working concentration ranges or the slopes. The proposed electrodes showed fairly good discriminating ability toward Al(III) ions in comparison with many other metal ions. The electrodes were applied successfully for Al(III) ions determination in drainage water, spiked tap water and pharmaceutical preparation samples. Furthermore, the electrode surfaces were characterized using energy-dispersive X-ray (EDX) and scanning electron microscopic (SEM) as surface characterization techniques and Fourier Transform Infrared (FT-IR) technique to confirm the interaction between Al(III) and DPC.