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211.
[reaction: see text] A sequential solid-phase peptide synthesis was developed using both photolabile linker and protecting groups. The chromatic sequential lability between a tert-butyl ketone-derived linker (sensitive to irradiation at 305 nm) and a nitroveratryloxycarbonyl (NVOC) group (sensitive at 360 nm) was exploited to prepare Leu-Enkephalin in a 55% overall yield. This new strategy allows the preparation of peptides in essentially neutral medium, by avoiding the use of common deprotection reagents such as trifluoroacetic acid or piperidine. 相似文献
212.
Feth MP Bolm C Hildebrand JP Köhler M Beckmann O Bauer M Ramamonjisoa R Bertagnolli H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(6):1348-1359
XANES and EXAFS spectroscopic studies at the Mn-K- and Br-K-edge of reaction products of (S,S)-(+)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride ([(salen)Mn(III)Cl], 1) and (S,S)-(+)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) bromide ([(salen)Mn(III)Br], 2) with 4-phenylpyridine N-oxide (4-PPNO) and 3-chloroperoxybenzoic acid (MCPBA) are reported. The reaction of the Mn(III) complexes with two equivalents of 4-PPNO leads to a hexacoordinated compound, in which the manganese atom is octahedrally coordinated by four oxygen/nitrogen atoms of the salen ligand at an average distance of approximately 1.90 A and two additional, axially bonded oxygen atoms of the 4-PPNO at 2.25 A. The oxidation state of this complex was determined as approximately +IV by a comparative study of Mn(III) and Mn(V) reference compounds. The green intermediate obtained in reactions of MCPBA and solutions of 1 or 2 in acetonitrile was investigated with XANES, EXAFS, UV/Vis, and Raman spectroscopy, and an increase of the coordination number of the manganese atoms from 4 to 5 and the complete abstraction of the halide was observed. A formal oxidation state of IV was deduced from the relative position of the pre-edge 1s-->3d feature of the X-ray absorption spectrum of the complex. The broad UV/Vis band of this complex in acetonitrile with lambda(max)=648 nm was consistent with a radical cation structure, in which a MCPBA molecule was bound to the Mn(IV) central atom. An oxomanganese(V) or a dimeric manganese(IV) species was not detected. 相似文献
213.
Monochrome coloured glass beads of the Merovingians (5th–7th cent. AD) have been examined by different analytical methods. The elemental composition of a large number of mostly unprepared
beads have been measured non-destructively by X-ray fluorescence analysis. After subtracting the content of the colouring
oxides of the glass beads and normalising the residual values to 100% an identical soda-lime-glass matrix was obtained. X-ray
diffraction was used for the identification of the crystalline colouring and opacifying pigments (SnO2, Cu, Cu2O, PbSnO3), and scanning electron microscopy as well as electron probe microanalysis were applied to study the microstructure and the
composition of white, brown, green, orange and yellow coloured glass beads. Oxidised metals, alloys (lead, copper, bronze,
brass and mixtures of them) and iron smelting slag have been identified as raw materials to colour the soda-lime-glass. 相似文献
214.
Kohtani M Jones TC Schneider JE Jarrold MF 《Journal of the American Chemical Society》2004,126(24):7420-7421
High-temperature ion mobility measurements have been performed for alpha-helical Ac-A15K+H+ and globular Ac-KA15+H+ peptides. The alpha-helical and globular conformations do not melt into random coils as the temperature is raised. Instead, both conformations survive to the point where the peptide signals vanishes due to fragmentation. This occurs at 600 K for the globular Ac-KA15+H+ peptide and at 725 K for the alpha-helical Ac-A15K+H+. For the helical Ac-A15K+H+ peptide it appears that fragmentation is triggered by disruption of the helical conformation. 相似文献
215.
13-Hydroxyacenaphtho[1,2-b]quinolizinium bromide (13-HQBr)was selected as a fluorescence indicator to determine basic compounds in non-aqueous media. This compound possesses an acidic phenolic hydroxyl group. It presents varying absorption (ROH, 408, 430 nm; RO(-) 456, 478 nm) and excitation spectra (ROH, 425 nm; RO, 471 nm) depending on the pH of the media, but the same emission fluorescence spectrum (ROH = RO(-), 526 nm) at different pH in buffered aqueous solutions. However, in acidic non-aqueous media (acetic, formic and trifluoroacetic acids), it can be observed that the fluorescence emission spectra differ for the ionized (lambda(em) = 530 nm) and non-ionized (lambda(em) = 440, 470 nm) forms. The fluorescence intensity at the characteristic peaks depends on the acid-base equilibria in the ground and excited states. Therefore, this property could be used to evaluate the concentration of basic compounds, showing a good linearity range between fluorescence intensity and basic sample concentration. 相似文献
216.
We present results of extensive density functional theory (DFT) calculations for H and H2 interacting with NiAl(110). Continuous representations of the full dimensional potential energy surface (PES) for the H/NiAl(110) and H2/NiAl(110) systems are obtained by interpolation of the DFT results using the corrugation reducing procedure. We find a minimum activation energy barrier of approximately 300 meV for dissociative adsorption of H2, which is consistent with the energy threshold obtained in molecular beam experiments for H2 (nu=0). We explain vibrational enhancement observed in experiments as the consequence of vibrational softening in the entrance channel over the most reactive surface site. The H2/NiAl(110) PES shows a high surface site selectivity: for energies up to 0.1 eV above threshold, H2 adsorption can only take place around top-Ni sites (within a circle of radius approximately 0.3 A). A strong energetic corrugation is observed: energy barriers for dissociation vary by more than 1 eV between the most and the least reactive sites. In contrast, geometric corrugation is much less pronounced and comparable to that of low index single metal surfaces like Cu or Pt. 相似文献
217.
Hirst AR Smith DK Feiters MC Geurts HP 《Chemistry (Weinheim an der Bergstrasse, Germany)》2004,10(23):5901-5910
The self-assembly of diaminododecane solubilised by four different stereoisomeric dendritic peptides to form gel-phase materials in toluene was investigated. The second generation dendritic peptides were based on D- and L-lysine building blocks, and each contained three chiral centres. By designing dendritic peptides in which the configurations of the chiral centres were modified, and applying them as gelator units, the assembly of stereoisomers could be investigated. In all cases, the self-assembly of gelator units resulted in macroscopic gelation. However, the degree of structuring was modulated by the stereoisomers employed, an effect which changed the morphology and macroscopic behavior of the self-assembled state. Enantiomeric (L,L,L or D,D,D) gelator units formed fibrous molecular assemblies, whilst the racemic gel (50 % L,L,L : 50 % D,D,D) formed a flat structure with a "woven" appearance. Gelator units based on L,D,D or D,L,L dendritic peptides also formed fibrous assemblies, but small-angle X-ray scattering indicated significant morphological differences were caused by the switch in chirality. Furthermore, the macroscopic stability of the gel was diminished when these peptides were compared with their L,L,L or D,D,D analogues. In this paper it is clearly shown that individual stereocentres, on the molecular level, are directly related to the helicity within the fibre. It is argued that the chirality controls the pattern of hydrogen bonding within the assembly, and hence determines the extent of fibre formation and the macroscopic gel strength. 相似文献
218.
Structural distortions within the extensive family of organic/inorganic hybrid tin iodide perovskite semiconductors are correlated with their experimental exciton energies and calculated band gaps. The extent of the in- and out-of-plane angular distortion of the SnI4(2-) perovskite sheets is largely determined by the relative charge density and steric requirements of the organic cations. Variation of the in-plane Sn-I-Sn bond angle was demonstrated to have the greatest impact on the tuning of the band gap, and the equatorial Sn-I bond distances have a significant secondary influence. Extended Hückel tight-binding band calculations are employed to decipher the crystal orbital origins of the structural effects that fine-tune the band structure. The calculations suggest that it may be possible to tune the band gap by as much as 1 eV using the templating influence of the organic cation. 相似文献
219.
A C60-centered dendritic adduct with 12 symmetrically attached pyrene species was synthesized and found to have relatively simple fluorescence emission kinetics, in particular, the mono-exponential decay of the significant pyrene excimer emission. 相似文献
220.
T-2 toxin and diacetoxyscirpenol (DAS), two trichothecene mycotoxins containing one hydroxy group, have been volatilized by induction heating, revolatilized, and analyzed by gas chromatography (GC) and/or GC mass spectroscopy. Seventy to eighty percent of DAS was recovered by this system; 60–70% T-2 toxin was recovered. When the hydroxy group is derivatized by acetate, 90–100% recovery is obtained. Other trichothecenes of the macrocyclic ester type (e.g., Roridan A) were also tried. Ten to twenty percent of the macrocyclic ester was obtained without derivatization. 相似文献