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991.
The refolding of the reduced-denatured insulin from bovine pancreas was investigated with the size exclusion chromatography (SEC). It was shown that the reduced-denatured insulin originally denatured with 7.0 mol L?1 guanidine hydrochloride (GuHCI) or 8.0 mol L?1 urea could not be refolded with a non-oxidized mobile phase. Although the oxidized and reduced glutathione (GSSG and GSH) were employed in the oxidized mobile phase, the reduced-denatured insulin still could not be renatured. However, in the presence of 2.0 mol Lt-1 urea in the oxidized mobile phase employed, the reduced-denatured insulin can be refolded with SEC, and the aggregation of denatured insulin can be diminished by urea. In addition, the disulfide exchange of reduced-denatured insulin also can be accelerated with GSSG/GSH in the oxidized mobile phase. The three disulfide bridges of insulin were formed correctly and the reduced-unfolded insulin can be renatured completely. The results were further tested with reversed-phase liquid chromatography (RPLC) and hydrophobic interaction chromatography (HIC). 相似文献
992.
PS-TEMPO, a polymer-supported 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), was successfully applied as a recyclable, active and selective catalyst for the oxidation of primary aliphatic and benzylic alcohols to aldehydes by molecular oxygen in the presence of Co(NO3)2 and Mn(NO3)2 as co-catalysts. 相似文献
993.
Dr. Alexandra R. McNeill Dr. Rodrigo Martinez-Gazoni Prof. Roger J. Reeves Prof. Martin W. Allen Prof. Alison J. Downard 《Chemphyschem》2021,22(13):1344-1351
ZnO is a strong candidate for transparent electronic devices due to its wide band gap and earth-abundance, yet its practical use is limited by its surface metallicity arising from a surface electron accumulation layer (SEAL). The SEAL forms by hydroxylation of the surface under normal atmospheric conditions, and is present at all crystal faces of ZnO, although with differing hydroxyl structures. Multilayer aryl films grafted from aryldiazonium salts have previously been shown to decrease the downward bending at O-polar ZnO thin films, with Zn−O−C bonds anchoring the aryl films to the substrate. Herein we show that the Zn-polar (0001), O-polar (000 ), and non-polar m-plane (10 0) faces of ZnO single crystals, can also be successfully electrografted with nitrophenyl (NP) films. In all cases, X-ray photoelectron spectroscopy (XPS) measurements reveal that the downward surface band bending decreases after modification. XPS provides strong evidence for Zn−O−C bonding at each face. Electrochemical reduction of NP films on O-polar ZnO single crystals converts the film to a mainly aminophenyl layer, although with negligible further change in band bending. This contrasts with the large upward shifts in band bending caused by X-ray induced reduction. 相似文献
994.
This study aims to clarify the effects of carbon activation type and physical form on the extent of adsorption capacity and
desorption capacity of a bi-solute mixture of phenol and 2-chlorophenol (2-CP). For this purpose, two different PACs; thermally
activated Norit SA4 and chemically activated Norit CA1, and their granular countertypes with similar physical characteristics,
thermally activated Norit PKDA and chemically activated Norit CAgran, were used. The thermally activated carbons were better
adsorbers for phenol and 2-CP compared with chemically activated carbons, but adsorption was more reversible in the latter
case. 2-CP was adsorbed preferentially by each type of activated carbon, but adsorption of phenol was strongly suppressed
in the presence of 2-CP. The simplified ideal adsorbed solution (SIAS) model underestimated the 2-CP loadings and overestimated
the phenol loadings. However, the improved and modified forms of the SIAS model could better predict the competitive adsorption.
The type of carbon activation was decisive in the application of these models. For each activated carbon type, phenol was
desorbed more readily in the bi-solute case, but desorption of 2-CP was less compared with single-solute. This was attributed
to higher energies of 2-CP adsorption. 相似文献
995.
M. J. Musmar M. Robert Willcott Gary E. Martin Robert T. Gampe Masatomo Iwao Milton L. Lee Ralph E. Hurd Leroy F. Johnson Raymond N. Castle 《Journal of heterocyclic chemistry》1983,20(6):1661-1669
Development of successively higher field nmr spectrometers has facilitated the study of increasingly more complex molecules, although smaller molecules such as phenanthro[3,4-b]thiophene still offer very substantial assignment problems because of the highly congested nature of their 1H- and 13C-nmr spectra. Assignments of such spectra, if they are to be unequivocal, frequently require the utilization of two-dimensional nmr spectroscopic techniques. Total assignments of the 1H- and 13C-nmr spectra of phenanthro[3,4-b]thiophene are reported. Assignments were based on a conventional high resolution 500 MHz 1H-nmr spectrum, autocorrelated two-dimensional 1H-nmr spectra (COSY), two-dimensional 1H-13C chemical shift correlation spectra and a modified version of autocorrelated 13C-13C double quantum coherence two-dimensional nmr spectroscopy. From NOE measurements, a separation of 1.99 Å between H1 and H11 was computed, suggesting that phenanthro[3,4-b]thiophene has a pronounced helical conformation in solution. 相似文献
996.
The versatile coordination chemistry of the well‐investigated phosphoraneiminato‐ligand R3PN— ( I ) was extended by the successive introduction of protons to the phosphorus atom. The position of the resulting equilibrium between the NH‐phosphanylamido‐ [R2P‐NH—] and the PH‐phosphoraneiminato‐form [R2HP=N—] is affected by the Lewis acidity of the coordinated metal fragment. Experimental studies on complexes with various substitution patterns at the group 4 metal center R2HP=N[M] ( II ) were unambiguously confirmed by DFT‐calculations. The isolation of group 4 PH‐dihydrido‐phosphoraneiminato‐complexes RH2P‐N[M] ( III ) is prevented by the low thermodynamic stability of the target molecules, also supported by the results of ab initio calculations. However, an access to the by then unknown transition‐metal substituted iminophosphanes RP=N[M] ( IV ) was verified for the first time. Within extensive studies on the coordination chemistry of bis(imino)phosphoranes RP(=NR′)(=NR″), several species of group 4 complexes R(R′N=)P=N[M] ( V ) were isolated and structurally characterized. In this case, investigations on the NH/PH‐tautomerism were performed exclusively on theoretical level, because the required educts are experimentally non‐accessible due to their kinetic instability. 相似文献
997.
Transition structures associated with the C-C bond-formation step of the proline-catalyzed intermolecular aldol reaction
between acetone and isobutyraldehyde have been studies using density functional theory methods at the B3LYP/6-31G** computational
level. A continuum model has been selected to represent solvent effects. For this step, which is the stereocontrolling and
rate-determining step, four reactive channels corresponding to the syn and anti arrangement of the active methylene of the
enamine relative to the carboxylic acid group of l-proline and the re and si attack modes to both faces of the aldehyde carbonyl group have been analyzed. The B3LYP/6-31G**
energies are in good agreement with experiment, allowing us to explain the origin of the catalysis and stereoselectivity for
these proline-catalyzed aldol reactions.
Received: 2 April 2002 / Accepted: 18 July 2002 / Published online: 11 October 2002
Acknowledgements. This work was supported by research funds provided by the Ministerio de Educación y Cultura of the Spanish Government by
DGICYT (project PB98–1429). All the calculations were performed on a Cray–Silicon Graphics Origin 2000 of the Servicio de
Informática de la Universidad de Valencia. We are most indebted to this center for providing us with computer capabilities.
Correspondence to: L. R. Domingo e-mail: domingo@utopia.uv.es 相似文献
998.
Sandip Halder Theodor Schneller Rainer Waser Florian Thomas 《Journal of Sol-Gel Science and Technology》2007,41(3):203-207
Nickel thin films have been sputtered on standard Si/SiO2 substrates with TiO2 as an adhesive layer. The thermal stability of these substrates was analyzed. SEM images show an increase in grain size with
annealing temperature. They were found to be stable till 800°C, beyond which the nickel layer disintegrated. These substrates
were used for deposition of BaTiO3 and (Ba,Sr)TiO3 dielectric thin films under a reducing atmosphere. The dielectric thin films were processed with various pyrolysis and annealing
temperatures in order to optimize the dielectric properties. Increased pyrolysis temperatures showed an increase in the grain
size. Results on these nickelised substrates were finally compared with dielectric films deposited on platinized silicon substrates
under identical conditions but crystallized in an oxygen atmosphere. 相似文献
999.
Homocysteine is thought to be a risk factor for vascular disease and this has led to an increase in demand for its assay in clinical laboratories. An HPLC method, incorporating electrochemical detection, for measurement of plasma total homocysteine is presented. The method is simple to perform, precise and suitable for clinical applications. 相似文献
1000.
Haoshuang Gu Yongming Hu Hao Wang Xiangrong Yang Zhenglong Hu Ying Yuan Jin You 《Journal of Sol-Gel Science and Technology》2007,42(3):293-297
Single crystalline nanowires of lead titanate (PbTiO3) were fabricated by hydrothermal method at 200°C using lead acetate and n-tetrabutyl titanate as starting materials, where sodium hydroxide was served as a mineralizer. Crystalline phases, microstructure
and optical properties of PbTiO3 nanowires were investigated. The PbTiO3 nanowires were uniform and continuous along the long axis, and were composed of single crystalline PbTiO3 with a tetragonal perovskite structure. The diameter of a single nanowire was around 12 nm and the length reached up to 3 μm.
The chemical composition of the samples and the valence states of elements were determined by X-ray photoelectron spectroscopy
(XPS). The ultraviolet/visible absorption spectroscopic investigation suggested that the absorption edge of optical transition
of the first excitonic state occurred at around 320 nm. A blue-green light emission peaking at about 471 nm (2.63 eV) is observed
at room temperature, and the intensity of this emission increased with increasing excitation wavelength. Oxygen vacancies
are responsible for the light emission of PbTiO3 nanowires. 相似文献