X-ray crystal and molecular structure of [3,6-bis(2-pyridyl)pyridazine-N 1,N2]bis(triphenylphosphine) copper(I) hexafluorophosphate

[3,6-bis(2-pyridyl)pyridazine-N ¹,N²]bis(triphenylphosphine) copper(I) hexafluorophosphate crystallizes in space group $P\bar 1$ with cell dimensionaa=14.050(2),b=11.941(2),c=15.200(2) Å, α=71.28(1), β=67.02(1), and γ=84.78(2)^o. In the title compound, the mononuclear cation consists of a tetrahedral copper(I) center involving two nitrogen donors of the 3,6-bis(2-pyridyl)pyridazine (dppn) and two P atoms of the triphenylphosphine molecules. In the dppn ligand the two non-coordinating N atoms (one from pyridine and one from pyridazine) are mutallytrans.     

DNA damage induced by sulfite autoxidation catalyzed by copper(II) tetraglycine complexes

Copper(II)/(III) tetraglycine complexes were investigated for their ability to catalyze the autoxidation of sulfite resulting in oxidative DNA damage. The focus of this work is on DNA damage by Cu(III) and oxysulfur radicals formed by the oxidation of S(IV) oxides by dissolved oxygen in the presence of Cu(II) tetraglycine complexes. The results suggest that sulfite is rapidly oxidized by oxygen in the presence of Cu(II) complexes producing Cu(III) tetraglycine, which can be monitored spectrophotometrically at 365 nm. A synergistic effect of Cu(II) with a second metal ion (Ni(II), Co(II) or Mn(II) traces) was observed.     

Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract

The present work is focused on the characterisation of the polyphenolic content of an Oxalis pes-caprae L. leaf extract and on the evaluation of its bioactivity with particular interest on its vascular activity and antioxidant potential. The polyphenolic content was characterised by HPLC-DAD and LC-MS/MS. The vascular activity was evaluated according to the influence on the serotonergic and adrenergic systems of the human internal mammary artery (HIMA). Antioxidant and neuroprotective studies were also conducted. Several luteolin and apigenin derivatives were identified as main constituents of the extract, which did not present any contractile effect nor had any effect on the serotonergic system of HIMA. However, it showed antagonistic effect on the adrenergic system, inhibiting the contraction to noradrenaline (reduction of 58.44% of maximum contraction). The extract showed antioxidant activity and standardised luteolin and apigenin derivatives showed neuroprotective potential, particularly homoorientin.     

The first catalytic asymmetric addition of dialkylzincs to alpha-ketoesters

[formula: see text] The first catalytic, enantioselective addition of organoznic reagents to alpha-ketoesters is described. Modular bifunctional salen catalysts that contain Lewis acid and Lewis base activating groups accelerate the carbonyl addition to a much greater extent than the competing carbonyl reduction. alpha-Hydroxyesters containing new quaternary stereogenic centers are obtained in high yield and moderate enantiomeric excess. Enrichment to 98% ee can be effected by recrystallization of the corresponding alpha-hydroxy acid.     

Phytosanitary irradiation for export of fresh produce: commercial adoption in Hawaii and current issues

Hawaii is a pioneer in the use of phytosanitary irradiation. Irradiation is an approved treatment to control quarantine insect pests in 17 fruits and 7 vegetables for export from Hawaii to the US mainland. The commercial X-ray irradiation facility, Hawaii Pride LLC, has been shipping tropical fruits and vegetables to the US mainland using irradiation since 2000. Hawaiian purple sweet potato is the highest volume product with annual exports of more than 12 million lbs (5,500 tonnes). The advent of generic radiation treatments for tephritid fruit flies (150 Gy) and other insects (400 Gy) has accelerated commodity export approvals and facilitated adoption by foreign trading partners. Current impediments to wider adoption include the labeling requirement, the 1 kGy limit for fresh horticultural products, and non-acceptance of phytosanitary irradiation in Japan and the European Union. USDA Animal and Plant Health Inspection Service (APHIS) has restricted the use of modified atmosphere packaging (MAP) for irradiated fresh fruits exported to the US due to possible increased radio-tolerance in the target insects. Data are presented for response of melon fly in papaya to several types of MAP with radiation treatment at 45–65 Gy. Low oxygen atmospheres can increase insect radio-tolerance, but the effect is dependent on oxygen concentration and radiation dose.     

Evaluation of different PAMAM dendrimers as molecular vehicle of 1,2,4-triazine N-oxide derivative with potential antitumor activity

The interaction between a 1,2,4-triazine N-oxide derivative, that holds potential antitumor activity under hypoxic conditions, and diverse polyamidoamine (PAMAM) dendrimers were investigated with the purpose of select the most appropriate macromolecule to act as potential molecular carrier of this active compound. The results shows that dendrimers with amine terminal groups (PAMAM-AT G = 3) and dendrimers with carboxylate terminal groups (PAMAM-CT G2.5 and G4.5) produces triazine derivative hydrolysis, even in buffered medium, and are not suitable as carriers. In contrast, dendrimers with neutral end groups (PAMAM-OHT) shows stable association with the active compound, making this dendrimer a possible medium for triazine carriage.     

Thermal behavior of coffee oil (Robusta and Arabica species)

Coffee seeds are a source for obtaining oil which is used in the candy, soluble coffee, and cosmetics industries. The main purpose of this study was the investigation of the lipid profile and thermal behavior of the roasted and in nature coffee oil of Arabica and Robusta species, using thermogravimetry, differential thermal analysis, derivative thermogravimetry, differential scanning calorimetry (DSC), and modulated DSC. Details concerning the thermal decomposition as well as data of the kinetic parameters have been described here. The kinetic studies were evaluated from several heating rates with a sample mass of 10 mg in open crucible under nitrogen atmospheres. The obtained data were evaluated with the isoconversional kinetic method, where the values of activation energy (E _a/kJ mol^?1) were evaluated in function of the conversion degree (α). In addition, this oil was evaluated by modulated DSC from 25 to ?60 °C, where the transition phase behavior was verified.