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31.
Summary LetX⊂P 3 be an irreducible smooth curve which is not a complete intersection. The main result of this paper shows that whenX is an a.c.i. of special type, i.e. its homogeneous ideal is generated by three polynomial of the same degreem, and additionallym>2, the subbundles of maximal degree of the normal bundle ofX inP 3 correspond to the singular points of maximal multiplicity of a plane curve which is the image ofX by a map (the linear system of the surfaces of minimal degree throughX). In particular this normal bundle is stable. The initial case of this family of curves, i.e. form=3, has been studied by E. Ballico-Ph. Ellia with different methods.
Riassunto SiaX⊂P 3 una curva irriducibile e liscia che non è una completa intersezione. Il risultato principale di questa Nota mostra che quandoX è una almost completa intersezione di tipo speciale, cioè il suo ideale omogeneo è generato minimamente da 3 polinomi dello stesso gradom, e, inoltre,m>2, i sottofibrati di grado massimo del fibrato normale diX inP 3 corrispondono ai punti singolari di molteplicità massima di una curva piana che è l’immagine diX tramite una mappa (il sistema lineare delle superficie di grado minimo passanti perX). In particolare questo fibrato normale è stabile. Il caso iniziale di questa famiglia di curve, i.e. perm=3, è stato studiato da E. Ballico-Ph. Ellia con differenti metodi.


This research is supported by GNSAGA (Italy).

The main results of this paper have been the object of a talk at the meeting on ?Curves in Projective Space? held at Rocca di Papa in june 1985.  相似文献   
32.
Redox condensation of [Ru3H(CO)11]- with Ni(CO)4, in tetrahydrofuran solution, under a nitrogen atmosphere, yields the tetranuclear anion [NiRuH(CO)11)-. Subsequent deprotonation with Bu'OK in acetonitrile solution leads to the formation of the related dianion. Both anions have been characterized by spectroscopic techniques, elemental analysis and single crystal X-ray diffraction. [PPh4][NiRu3H(CO)12] crystallizes in the triclinic space group PI with unit cell dimensionsof a = 11.842(2) Å,b = 12.335(3) Å, c = 13.3080) Å,a = 91.89(2)°, = 93.35(1)°,y = 96.41(2)°, Z = 2, V= 1926.9(7) Å'. The NiRu3, metal core of the molecule defines a distorted tetrahedron with nine terminal and three edge bridging carbonyl groups. The hydrido ligand was located by difference Fourier techniques and was found to bridge the NiRu2 basal triangle at a distance of 0.88(6) A from this plane. Selected average distances and angles are: Ru-Ru = 2.839 Å, Ru-Ni = 2.640 Å, Ru-C, = 1.910 A,Ru-C b = 2.084 Å, Ni-C b = 2.022 Å, Ru-H = 1.77 Å, C-0, = 1.135 Å, C-O b = 1.159 Å, M-C-O, = 176.3°,M-C--O b = 139.3°;other distances are: Ni-C1 = l.758(7) Å, Ni-H= 1.85(7) Å. [NEt4]2[NiRu3(CO)12] crystallizes in the orthorhombic space group Pnma (no. 62) with unit cell dimensions ofa=20.247(5) Å,b = 15.038(4)Å,c = 12.079(3) Å, Z=4, V=3678(2) A'. The molecule contains a tetrahedral NiRu3 core with eight terminal and four edge bridging carbon monoxide groups which bridge the three Ni-Ru and one Ru-Ru bond. Average distances and angles are: Ru -Ru =2.3050A Ru-Ni 2.648 Å, Ru-C t = 1.878 Å, Ru-C b 2.045 Å, Ni-C b = 2.055 Å, C-O t = 1.145 Å, C-01,=1.157 Å, M-C-O,= 176.9°, M-C-O b = 138.6°; other distance is: Ni-C t = 1.754(10) Å,t = terminal,b = bridging.  相似文献   
33.
In this review anti-metatype antibodies are described invoking new principles in immunoassay development. Anti-metatype antibodies are immunological reagents specific for the conformation of the liganded antibody active site which do not interact with bound ligand or unliganded antibody. Relationships between anti-metatype antibody reactivity and the ligand-induced conformational state of monoclonal antibodies are reviewed with emphasis on the fluorescein hapten as a small molecule model system. One characteristic result of the interaction of anti-metatype antibodies with liganded antibodies is a significant delay in the dissociation rate (k2) of the ligand bound within the primary immune complex. The latter is an important consideration for assay development. Polyclonal and monoclonal anti-metatype antibody reagents are characterized in terms of their differential effects on the ligand dissociation rate. Anti-metatype antibody reactivity is further discussed in terms of protein-protein specificity patterns and relative interactions with idiotype-family members, structural derivatives, and site-specific mutants. Incorporation of principles inherent in the anti-metatype concept and their application to assay development are summarized.Abbreviations D2O deuterium oxide - Fab 50 kd antibody fragment containing VHCH1 + VLCL domains - FITC(I) fluorescein isothiocyanate (isomer I) - Fv 26 kd fragment of the antibody molecule containing the variable domains of the H and L chains - Ig immunoglobulin - IgG immunoglobulin G with a mol. wt. of 150 kd. - IgM immunoglobulin M with a mol. wt. of 106d - Id idiotype - Ka antibody affinity (k1/k2) in M–1 - k1 second order rate of ligand association in M–1s–1 - k2 first order rate of ligand dissociation in s–1 - KD dissociation constant or the reciprocal of the affinity constant (1/Ka) - Mab monoclonal antibody - Met metatype - NMR nuclear magnetic resonance - SCA single chain Fv derivative containing a synthetic linker between the two variable domains - VH variable domain of the antibody H chain - VL variable domain of the antibody L chain  相似文献   
34.
5-Alkynylpyridazin-3(2H)-ones or 5-(2-chloroalkenyl)pyridazin-3(2H)-ones were isolated during the cleavage of the methoxymethyl group in a series of 5-alkynyl-2-methoxymethylpyridazin-3(2H)-ones by treatment with hydrochloric acid. The efficient and selective cleavage of the methoxymethyl group in these compounds can be performed under mild conditions by employing aluminium chloride.  相似文献   
35.
Optical sensors based on hybrid DNA/conjugated polymer complexes   总被引:2,自引:0,他引:2  
Single-stranded DNA (ss-DNA) can specifically bind to various targets, including a complementary ss-DNA, ions, proteins, drugs, and so forth. When binding takes place, the oligonucleotide probe often undergoes a conformational transition. This conformational change of the negatively charged ss-DNA can be detected by using a water-soluble, cationic polythiophene derivative, which transduces the complex formation into an optical (colorimetric or fluorometric) signal without any labeling of the probe or the target. This simple and rapid methodology has enabled the specific and sensitive detection of nucleic acids and human thrombin. This new biophotonic tool can easily be applied to the detection of various other biomolecules and is also useful in the high-throughput screening of new drugs.  相似文献   
36.
A 2D coordination compound {[Cu2(HL)(N3)]?ClO4} ( 1 ; H3L=2,6‐bis(hydroxyethyliminoethyl)‐4‐methyl phenol) was synthesized and characterized by single‐crystal X‐ray diffraction to be a polymer in the crystalline state. Each [Cu2(HL)(N3)]+ species is connected to its adjacent unit by a bridging alkoxide oxygen atom of the ligand to form a helical propagation along the crystallographic a axis. The adjacent helical frameworks are connected by a ligand alcoholic oxygen atom along the crystallographic b axis to produce pleated 2D sheets. In solution, 1 dissociates into [Cu2(HL)2(H3L)]?2H2O ( 2 ); the monomer displays high selectivity for Zn2+ and can be used in HEPES buffer (pH 7.4) as a zinc ion selective luminescent probe for biological application. The system shows a nearly 19‐fold Zn2+‐selective chelation‐enhanced fluorescence response in the working buffer. Application of 2 to cultured living cells (B16F10 mouse melanoma and A375 human melanoma) and rat hippocampal slices was also studied by fluorescence microscopy.  相似文献   
37.
The new hexaalkylborazine chromium tricarbonyls (n-Pr)3B3N3Me3Cr(CO)3 (V), Me3B3N3(n-Pr)3Cr(CO)3 (VI), (i-Pr)3B3N3Me3Cr(CO)3 (VII) and Me3B3N3(i-Pr)3Cr(CO)3 (VIII) have been prepared from fac-Cr(CO)3(MeCN)3 and the corresponding borazine in dioxane or without solvent. They are much more labile than the isomeric complex Et3B3N3Et3Cr(CO)3 (IV) which can be readily obtained from Et3B3N3Me3Cr(CO)3 and Et3B3N3Et3 by ring ligand exchange. The NMR., IR., UV. and Mass spectroscopic data of the complexes IV–VIII will be briefly discussed. The preparation of the borazine derivatives (n-Pr)3B3N3Me3 (IX) and Me3B3N3(n-Pr)3 (X) is also reported.  相似文献   
38.
Hydrogen transfer from racemic alcohols to prochiral ketones in the presence of H4Ru4(CO)8[(?)-DIOP]2 has been examined. The enantiomer-discrimination is influenced by the structure of the reactants, temperature and the excess of phosphine present.  相似文献   
39.
The first total synthesis of (±)-cyclooroidin, a member of the pyrrole-imidazole alkaloid family recently isolated from the sponge Agelas oroides in optically pure form, is described. The synthesis was achieved in nine linear steps, with an overall yield of 10%. Key step was a Wolff bromoketone synthesis performed on the intermediate longamide B.  相似文献   
40.
Although fluorescein is a widely used fluorescent probe in the biosciences, the effect of solvent environment on its spectral properties is poorly understood. In this paper we explore the use of fluorescein as a probe of the state of hydrogen bonding in its local environment. This application is based on the observation, originally made by Martin ( Chem. Phys. Lett . 35, 105–111, 1975), that the absorption maximum of fluorescein undergoes substantial shifts in organic solvents related to the hydrogen bonding power of the solvents. We have extended this work by studying the spectral properties of the dianion form of the probe in solvent–water mixtures. We show that the magnitude of the shift correlates with the α and β parameters of Kamlet and Taft ( J. Am. Chem. Soc . 98, 377–383; 2886–2894, 1976), which provide a scale of the hydrogen bond donor acidities and acceptor basicities, respectively, of the solvents. In solvent–water mixtures, these shifts reflect general effects of the solvents on the hydrogen bonding environment of the fluorescein through water–solvent hydrogen bonding and specific effects due to fluorescein–solvent hydrogen bonding. Indeed, both the absorption and fluorescence properties appear to be dominated by these effects indicating that the spectral shifts of the dianion can be used as an indicator of its hydrogen bonding environment. We discuss the application of fluorescein as a probe of hydrogen bonding in the microenvironment immediately surrounding the fluorophore, and we illustrate the effect with reference to the fluorescein–antifluorescein antibody complex where it appears that antibodies selected during the immune response possess binding sites that are increasingly dehydrated and hydrophobic.  相似文献   
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