Biological evaluation of redox stable cisplatin/Cu(II)-DNA adducts as potential anticancer agents

A series of non-enolizable β-diketonate-based copper(II) complexes with LCuCl₂ [L = Knoevenagel condensates of curcumin (Salcimine) and methylacetoacetate (SalMaA)-based Schiff bases] chromospheres as functional models of chemotherapy drug cisplatin were investigated for their covalent interaction with herring sperm DNA. The synthesis and structural characterization of 1a and 1b have been reported in our previous article. However, their DNA interactions and cytotoxicity properties were not studied. These analyses have been carried out mainly through electrochemical techniques supplemented with spectral, relative viscosity, gel electrophoresis techniques, and AGS cancer cells using MTT assay. The cytotoxic activities of the ligand, curcumin-based copper complex, and cisplatin were tested against the AGS cancer cell line under similar experimental conditions showing that the complex exhibited cancer cell inhibitory rate closer to cisplatin even at low concentration. This was also seen in the docking of the Cu-complex onto a rich guanine B-DNA decamer, where a Cu–N3_(guanine) interaction instead of Pt-N7 as cisplatin is detected. The obtained results in this study prove that these complexes could be a promising substitute for cisplatin as a new family of non-platinum-based anticancer metallo-drugs after in vivo tests on animal models.     

Analysis of curved beams using a new differential transformation based curved beam element

Differential transformation method is used to obtain the shape functions for nodal variables of an arbitrarily non-uniform curved beam element including the effects of shear deformation considering axially functionally graded material. The proposed shape functions depend on the variations in cross-sectional area, moment of inertia, curvature and material properties along the axis of the curved beam element. The static and free vibration of axially functionally graded tapered curved beams including shear deformation and rotary inertia are studied through solving several examples. Numerical results are presented for circular, parabolic, catenary, elliptic and sinusoidal beams (both forms—prime and quadratic) with hinged-hinged, hinged-clamped and clamped-clamped and clamped-free end restraints. Three general taper types (depth taper, breadth taper and square taper) for rectangular cross section are studied. Out of plane vibration is studied and the lowest natural frequencies are calculated and compared with the published results. Out of plane buckling is investigated for circular beams due to radial load.     

Design,synthesis and exploration of in silico α-amylase and α-glucosidase binding studies of pyrrolidine-appended quinoline-constrained compounds

Research on Chemical Intermediates - A series of new pyrrolidine-appended phenoxy-substituted quinoline derivatives were synthesized using 2-chloro-3-formyl quinoline. Initially, the second...     

Contribution of gluons and coloured Higgs bosons to e+-e− annihilation into three jets

Three-jet thrust and angular distributions in e⁺e^? annihilation are calculated in the integer-charge quark model. The complete contributions of gluons and Higgs scalars are presented. Deviations from QCD results are in general less than or comparable to the experimental errors, except for m_g ? 2 GeV and m_H ? 30 GeV.     

Neutral currents in left-right symmetric gauge models

We analyse all the neutral-current phenomena following from the general class of gauge models based on the group SU(2) _L ⊗ SU(2) _R ⊗ U(1). It is found that the neutral-current couplings in these models bear a remarkable similarity to those in the standard Weinberg-Salam gauge model. The parameter which plays the role of sin²ϑ_w is found to lie between 0 and 1/2. Comparison with experimental data shows that even a model with the ratio of the masses of the twoZ bosons as small as 1.9 is not ruled out.     

Stability of theS matrix pole

We show how the position and residue of theS matrix pole can remain stable under changes in the form of the parametrization of theS matrix elements. We also derive a relation among the shifts in the Breit-Wigner resonance parameters under the same changes and verify the relation numerically for the case of Δ(1232). Despite its stability, the pole does not provide a unique definition of the resonance because of the existence of shadow poles.     

Finite size nucleonic effects in the nuclear medium

The finite size effects of nucleons inside a nucleus is investigated. This new approach is entirely different from Hagedorn’s volume correction method and is more rigorous. The size of the nucleon is varied and the magnitude of the hard-core potential is extracted by minimising the energy with respect to the nuclear radius.     

Analysis of the neutral-current interaction in the inclusive neutrino reactions

We attempt a general phenomenological analysis of the neutral weak current in the inclusive neutrino reactions using the parton model as a tool. From the recently reported data on these processes we determine the strengthH of the neutral-current interaction as well as the amount of theVA interference. We find (H/G)²=0·54±0·06 whereG is the Fermi coupling constant and theVA interference contribution turns out to be 33±23%. We also discuss the comparison of the data with various models for the neutral hadronic current. An erratum to this article is available at .     

Free vibration analysis of axially functionally graded tapered Timoshenko beams using differential transformation element method and differential quadrature element method of lowest-order

The present paper investigates the free vibration characteristics of Timoshenko beams whose cross-sectional profile and material properties vary along the beam axis with any arbitrary functions. Free vibration analysis of these beams is carried out through solving the governing differential equations of motion. Since the application of differential transformation method (DTM) does not necessarily converge to satisfactory results, an element-based differential transformation method, namely differential transformation element method (DTEM), is introduced which significantly enhances the accuracy of the results. Furthermore, differential quadrature element of the lowest order (DQEL) is introduced which is based on differential quadrature element method (DQEM). DQEL formulates the problem on the basis of the interpolation of the first differential of the functions; therefore, in contrast with DQEM higher differentials of functions are not employed in DQEL. The competency of DQEL and DTEM in free vibration analysis is verified through several numerical examples. The effects of taper ratio and material non-homogeneity on natural frequencies are investigated.     

An N-heterocyclic carbene-catalyzed [8 + 3] annulation of tropone and enals via homoenolate

A novel protocol for the annulation of tropone to enals involving nucleophilic heterocyclic carbene (NHC) catalyzed homoenolate formation has been developed. Interestingly, the reaction led to bicyclic delta-lactones instead of the expected gamma-spirolactones, presumably by the uncommon [8 + 3] annulation pathway. The strategy works well with a variety of enals.