Elastic stability of all edges simply supported,stepped and stiffened rectangular plate under Biaxial loading

In this paper using finite difference method the lower bound buckling load for simply supported (a) stepped and stiffened rectangular thin plate (b) linear and non-linear variation of thickness (c) uniformly distributed compressive forces in both directions (d) uniformly distributed compressive force in y direction and non-uniform distribution of compressive force in x-direction is discussed. The thin plate is divided into 900 rectangular meshes. The partial derivatives are approximated using central difference formula. Eight hundred and forty one equations are formed and using the program developed and the least eigenvalue is obtained. The buckling coefficients are calculated for different types of stepped and non prismatic plates and the results are presented in tables and graphs for ready use by designers. Buckling factors for some cases are presented in the form of three separate tables and compared with the values obtained by Xiang, Wei and Wang. The results are in close agreement.     

Designing,Structural Elucidation and Comparison of the Cleavage Ability of Metal Complexes Containing Tetradentate Schiff Bases 1

New N₂O₂ donor type Schiff bases have been designed and synthesized by condensing acetylaceto-4-aminoantipyrine/acetoacetanilido-4-aminoantipyrine with 2-amino benzoic acid in ethanol. Solid metal complexes of the Schiff bases with Cu(II), Ni(II), Co(II), Mn(II), Zn(II), VO(IV), Hg(II) and Cd(II) metal ions were synthesized and characterized by elemental analyses, magnetic susceptibility, molar conduction, FAB Mass, IR, UV-Vis., ¹H NMR, and ESR spectral studies. The data show that the complexes have a composition of the ML type. The UV-Vis., magnetic susceptibility, and ESR spectral data of the complexes suggest a square planar geometry around the central metal ion, except for VO(IV) complexes, which have square-pyramidal geometry. The redox behavior of copper and vanadyl complexes has been studied by cyclic voltammetry. The nuclease activity of the above metal complexes shows that the complexes cleave DNA through redox chemistry. In the presence of H₂O₂, all the complexes are capable of cleaving calf thymus DNA plasmids, in order to compare the cleavage efficiency of all metal complexes in the two different ligand environments. In this assay, Cu(II), Ni(II), Co(II), and Zn(II) exhibit more cleavage efficiency than other metal ions. This article was submitted by the authors in English.     

Synchronous Luminescence Spectroscopic Characterization of Urine of Normal Subjects and Cancer Patients

Urine is one of the diagnostically potential bio fluids, as it contains many metabolites and some of them are native fluorophores. These fluorophores distribution and the physiochemical properties may vary during any metabolic change or at different pathologic conditions. Since urine is a multicomponent fluid, synchronous luminescence technique, a powerful tool has been adopted to analyse multicomponents in single spectrum and to resolve emission spectrum without much of photobleaching of fluorophores. In this study, urine samples of both normal subjects and cancer patients were characterised using synchronous luminescence spectroscopy with a Stokes shift of 20 nm. Different ratio parameters were calculated from the intensity values of the synchronous luminescence spectra and they were used as input variables for a multiple linear discriminant analysis across normal and cancer groups. The stepwise linear discriminant analysis classifies 90.3 % of the original grouped cases and 88.6 % of the cross-validated grouped cases correctly.     

Tuning the metal-adsorbate chemical bond through the ligand effect on platinum subsurface alloys

Scratching beneath the surface: Pt-M(3d)-Pt(111) (M(3d) = Co, Ni) bimetallic subsurface alloys have been designed to show the ligand effect tunes reactivity in oxygen and hydrogen adsorption systems. The platinum-oxygen bond order was investigated by oxygen atom projection in the occupied and unoccupied space using X-ray emission spectroscopy (XES) and X-ray absorption spectroscopy (XAS).     

Statistical theory of hot nuclei and high spin states

The hot rotating compound systems formed in heavy ion collisions are studied using the statistical theory with a view to determine the spin and temperature dependence of nuclear shapes. Shape transitions are observed for these systems at particular spin values. The neutron and proton separation energies for heavier high spin systems have been evaluated. Results are presented for ₇₀ ¹⁷⁰ Yb and ₇₈ ¹⁹⁴ Pt.     

Higgs couplings in the integer-charge quark model

Colour SU(3) symmetry is broken spontaneously by the introduction of coloured Higgs scalars in the standard SU(3)×SU(2)×U(1) model, so as to make the quarks integrally charged. The resulting couplings of the Higgs bosons with the gauge bosons are worked out.     

The phenomenon of nucleon emission at high angular momentum states of fused compound systems

Nucleon emission from high spin fused compound systems is analyzed in the framework of the statistical theory of hot rotating (STHR) nuclei. This is an elaborate version of our earlier work and we present our results for¹⁵⁶Er,¹⁶⁶Er,¹⁶⁸ Yb and¹⁸⁸Hg. We predict an increase in neutron emission for¹⁶⁶Er due to the abrupt decrease in neutron separation energy aroundI ≈55ℏ. Since the drop in the separation energy is closely associated with the structural changes in the rotating nuclei, relative increase in neutron emission probability around certain values of angular momentum may be construed as evidence for the shape transition. A similar effect is predicted for¹⁶⁸Yb aroundI ≈55ℏ. We also extend the microscopic cranked Nilsson method (CNM) to hot nuclear systems and compare the results with that of the STHR method. The two methods yield different results for triaxially deformed nuclei although for biaxial deformations the results are identical. This is illustrated for¹⁸⁶Hg.     

Generalized Fock spaces,new forms of quantum statistics and their algebras

We formulate a theory of generalized Fock spaces which underlies the different forms of quantum statistics such as ‘infinite’, Bose-Einstein and Fermi-Dirac statistics. Single-indexed systems as well as multi-indexed systems that cannot be mapped into single-indexed systems are studied. Our theory is based on a three-tiered structure consisting of Fock space, statistics and algebra. This general formalism not only unifies the various forms of statistics and algebras, but also allows us to construct many new forms of quantum statistics as well as many algebras of creation and destruction operators. Some of these are: new algebras for infinite statistics,q-statistics and its many avatars, a consistent algebra for fractional statistics, null statistics or statistics of frozen order, ‘doubly-infinite’ statistics, many representations of orthostatistics, Hubbard statistics and its variations.     

Radiative stability of neutrino-mass textures

Neutrino-mass textures proposed at high scales are known to be unstable against radiative corrections especially for nearly degenerate mass eigenvalues. We find a mechanism in a class of gauge models including 2HDM where the RG constraints can be evaded. Consequently, a high-scale texture can match the low-energy data or be reproduced at low energies.     

Quantum chemical and molecular mechanics studies on the assessment of interactions between resveratrol and mutant SOD1 (G93A) protein

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that has been associated with mutations in metalloenzyme superoxide dismutase (SOD1) causing protein structural destabilization and aggregation. However, the mechanistic action and the cure for the disease still remain obscure. Herein, we initially studied the conformational preferences of SOD1 protein structures upon substitution of Ala at Gly93 in comparison with that of wild type. Our results corroborated with the previous experimental studies on the aggregation and the destabilizing activity of mutant SOD1 protein G93A. On the therapeutic point of view, we computationally analyzed the influence of resveratrol, a natural polyphenol widely found in red wine on mutant SOD1 relative to wild type, using molecular docking studies. Further, FMO calculations were performed, using GAMESS to study the pair residual interaction on the wild type and mutant complex systems. Consequently, the resveratrol showed greater interaction with mutant than the wild type. Subsequently, we evaluated the conformational preferences of wild type and mutant complex systems, where the protein conformational structures of mutant that were earlier found to lose their conformational stability was regained, upon binding with resveratrol. Similar trend of results were found on the 2-D free energy landscapes of both the wild type and mutant systems. Hence, the combined biophysical and quantum chemical studies in our study supported the results of previous experimental studies, thereby stipulating an action of resveratrol on mutant SOD1 and paving a way for the design of highly potent effective inhibitors against fALS affecting the mankind.