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81.
F. Bergsma J. Dorenbosch M. Jonker C. Nieuwenhuis J. V. Allaby U. Amaldi G. Barbiellini L. Barone A. Capone W. Flegel L. Lanceri M. Metcalf J. Panman R. Plunkett C. Santoni K. Winter I. Abt J. Aspiazu F. W. Büsser H. Daumann P. D. Gall T. Hebbeker F. Niebergall P. Schütt P. Stähelin V. Gemanov P. Gorbunov E. Grigoriev V. Kaftanov V. Khovansky A. Rosanov A. Baroncelli R. Biancastelli B. Borgia C. Bosio M. Diemoz U. Dore F. Ferroni E. Longo L. Luminari P. Monacelli F. de Notaristefani L. Tortora V. Valente CHARM Collaboration 《Zeitschrift fur Physik C Particles and Fields》1984,24(3):217-218
A search for fractionally chargedQ=1/3 (2/3) particles of different properties of interaction produced in (anti)neutrino-nucleus and in protonnucleus collisions was performed using the scintillator system of the CHARM neutrino detector at the CERN SPS. No events of the cases considered were found. In (anti)neutrino beams production was found to be less than a few times 10?5 per interaction of a beam particle. In a proton beam an upper limit on the production cross section of ~10?40 cm2 was obtained. 相似文献
82.
Hyaluronic Acid Nanoporous Microparticles with Long In Vivo Joint Residence Time and Sustained Release 下载免费PDF全文
Graziana Palmieri Antonio Rinaldi Luisa Campagnolo Mariarosaria Tortora Maria Federica Caso Maurizio Mattei Andrea Notargiacomo Nicola Rosato Massimo Bottini Francesca Cavalieri 《Particle & Particle Systems Characterization》2017,34(6)
A simple approach is reported to engineer biodegradable and biocompatible nanoporous hyaluronic acid particles (NPHAs) with a characteristic sponge‐like morphology and uniform size. These NPHAs can be synthesized using the concomitant cross‐linking of hyaluronic acid and the cross‐linking agent precipitation. The nanoporous architecture of NPHAs prevents the rapid enzymatic degradation of hyaluronic acid and controls the erosion of microparticles in physiological conditions. Once injected into an intra‐articular body cavity of healthy mice, these NPHAs reside at the point‐of‐delivery for an extended time period, exhibiting a sustained release of hyaluronic acid. In addition, in vivo studies indicate the persistence of NPHAs in the knee joints with neither accumulation into major organs, nor any local or systemic side‐effect. The use of NPHAs is emphasized as reservoirs of hyaluronic acid, effectively providing an innovative and safe platform for prolonging the favorable effects displayed by hyaluronic acid on joints affected by osteoarthritis. 相似文献
83.
Takaaki Nishida Mariarosaria Padula Yoshiaki Teramoto 《Journal of Mathematical Fluid Mechanics》2013,15(3):525-536
The stationary problem for the heat convection of compressible fluid is considered around the equilibrium solution with the external forces in the horizontal strip domain z 0 < z < z 0 + 1 and it is proved that the solution exists uniformly with respect to z 0 ≥ Z 0. The limit system as z 0 → + ∞ is the Oberbeck–Boussinesq equations. 相似文献
84.
Cristina Occhiuto Gianluigi Aliberto Mariarosaria Ingegneri Domenico Trombetta Clara Circosta Antonella Smeriglio 《Molecules (Basel, Switzerland)》2022,27(11)
Recently, there has been a growing interest in the recovery of agri-food waste within the circular economy perspective. In this study, the nutritional, phytochemical, and biological features of the cold-pressed hempseed oil (HSO) and hempseed meal (HSM) of two industrial hemp varieties (USO 31 and Futura 75, THC ≤ 0.2%) were evaluated. The HSOs showed a high total phenols and flavonoid content, which were confirmed by LC-DAD-ESI-MS analysis, with rutin as the most abundant compound (56.93–77.89 µg/100 FW). They also proved to be a rich source of tocopherols (81.69–101.45 mg/100 g FW) and of a well-balanced ω-6 to ω-3 fatty acid ratio (3:1) with USO 31, which showed the best phytochemical profile and consequently the best antioxidant activity (about two times higher than Futura 75). The HSMs still retained part of the phytochemicals identified in the HSOs (polyphenols, tocopherols, and the preserved ω-6/ω-3 fatty acids ratio) and a modest antioxidant activity. Furthermore, they showed a very interesting nutritional profile, which was very rich in proteins (29.88–31.44 g/100 g FW), crude fibers (18.39–19.67 g/100 g), and essential and non-essential amino acids. Finally, only a restrained amount of anti-nutritional factors (trypsin inhibitors, phytic acid, and condensed tannins) was found, suggesting a promising re-use of these byproducts in the nutraceutical field. 相似文献
85.
Giovanni Maglio Rosario Palumbo Mariarosaria Tortora 《Journal of polymer science. Part A, Polymer chemistry》2000,38(7):1172-1178
Poly(arylether benzoxazole)s (PAEBOs) were prepared from a series of fully aromatic dicarboxylic acids containing (phenylenedioxy)diphenylene or (naphthalenedioxy) diphenylene groups and 3,3′‐dihydroxy‐4,4′‐diaminobiphenyl (I) or 4‐4′‐(hexafluoroisopropylidene)bis(2‐aminophenol) (II) through high‐temperature direct polycondensation. A phosphorous pentoxide/methanesulfonic acid mixture or trimethylsilylpolyphosphate was used as a condensing agent. All the PAEBOs were amorphous and soluble in strong acids, and those derived from II were also readily soluble in polar organic solvents. Flexible films were cast from their chloroform solutions. The PAEBOs showed inherent viscosity values of 0.68–2.06 dL/g (CH3SO3H, T = 30 °C, c = 0.15 g · dL−1). Thermal analysis indicated glass‐transition temperatures ranging from 236 to 270 °C and thermal stability (5% weight loss) in nitrogen up to 526 °C. © 2000 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 38: 1172–1178, 2000 相似文献
86.
Pino Sabia Marco Lubrano Lavadera Giancarlo Sorrentino Paola Giudicianni Raffaele Ragucci Mariarosaria de Joannon 《Flow, Turbulence and Combustion》2016,96(2):433-448
MILD combustion is a very attractive technology because of its intrinsic features for energy production from diluted gas deriving from bio- or thermochemical degradation of biomass. An effective use of such a technology for diluted fuel requires a thorough analysis of ignition and oxidation behavior to highlight the potential effects of the different fuel components on the basis of temperature and diluent/oxygen/fuel mixture composition. In this work, ignition and oxidation of a model gas surrogate for the gaseous fraction of biomass pyrolysis products containing C1-C2 species, CO and CO2 were experimentally and numerically studied over a wide range of temperature and overall composition in the presence of large amounts of CO2 or H2O. Experimental results showed that such species significantly alter the evolution of the ignition process in dependence on temperature range and mixture composition. Several kinetic models were tested to simulate experimental results. Significant discrepancies occur, especially in the case of steam dilution. Numerical analyses suggested that such diluents acted mainly as third body species at low temperatures, conditioning both radical production pathways and the relative weight of C1 oxidation/recombination routes, while strongly interacting with the H2/O2 high temperature branching mechanisms at high temperatures. Further analyses are mandatory to improve the predictability of the models and extend the applicability of the chemical schemes to non-standard conditions. 相似文献
87.
88.
Francesca Cavalieri Marisa Colone Annarita Stringaro Mariarosaria Tortora Annarica Calcabrini Meifang Zhou Muthupandian Ashokkumar 《Particle & Particle Systems Characterization》2013,30(8):695-705
The ultrasound‐assisted self‐assembly and cross‐linking of lysozyme at the water–air and water–perfluorohexane interfaces are shown to produce lysozyme‐shelled hollow microbubbles (LSMBs) and microcapsules (LSMC), respectively. The arrangement of lysozyme at the air–liquid or oil–liquid interfaces is accompanied by changes in the bioactivity and conformational state of the protein. The interaction of LSMB and LSMC with human breast adenocarcinoma cells (SKBR3) is studied. LSMB and LSMC are phagocyted by cells within 2 h without exerting a cytotoxic activity. The cellular internalization kinetics of LSMB and LSMC and the effects on cell cycle are evaluated using flow cytometry. Evidence for the internalization of microparticles and degradation within the cell are also monitored by confocal and scanning electron microscopic analyses. The integrity of cell membrane and cell cycle is not affected by LSMBs and LSMCs uptake. These studies show that the positively charged LSMB and LSMC are not cytotoxic and can be readily internalized and degraded by the SKBR3 cells. LSMBs and LSMCs show a different uptake kinetics and intracellular degradation pattern due to differences in the arrangement of the protein at the air–liquid or oil–liquid interfaces. 相似文献
89.
Natale Badalamenti Maurizio Bruno Rosario Schicchi Anna Geraci Mariarosaria Leporini Luigia Gervasi Rosa Tundis Monica Rosa Loizzo 《Molecules (Basel, Switzerland)》2022,27(5)
In this work, seven Citrus aurantium essential oils (EOs) derived from flavedo of cultivars ‘Canaliculata’, ‘Consolei’, ‘Crispifolia’, ‘Fasciata’, ‘Foetifera’, ‘Listata’, and ‘Bizzaria’ were investigated. EOs were also combined in 1:1 (v/v) ratio to identify possible synergism or antagonism of actions. GC-MS analysis was done to investigate Eos’ phytochemical profiles. The antioxidant activity was studied by using a multi-target approach based on FRAP, DPPH, ABTS, and β-carotene bleaching tests. A great difference was observed in EOs’ phytochemical profiles. d-limonene (33.35–89.17%) was the main monoterpene hydrocarbon, and α-Pinene, β-myrcene, and β-linalool were identified in almost all samples. Among EOs, only C3 showed high quantitative and qualitative variability in its chemical composition. The chemical diversity of EOs was also demonstrated by PCA and HCA statistical analysis. Samples C2, C4, C5, C6, and C7 were statistically similar to each other, while C1 and C3 were characterized as having a different amount of other compounds and oxygenated monoterpenes, respectively, with respect to the other EOs mentioned. The global antioxidant score (GAS) revealed that among the tested EOs, C. aurantium ‘Fasciata’ EO had the highest antioxidant potential, with a GAS value of −0.47, whereas among combinations, the EO obtained by mixing ‘Canaliculata’ + ‘Bizzaria’ was the most active. Comparison by theoretical and real data on inhibitory concentration (IC50) and FRAP values did not reveal any significant effect of synergism or antagonism of actions to be valid in all biological applied tests. These findings, considered together, represent an important starting point to understand which compounds are responsible for the activities and their future possible industrial application. 相似文献
90.
Alessio Malacrida Valeria Cavalloro Emanuela Martino Giosu Costa Francesca Alessandra Ambrosio Stefano Alcaro Roberta Rigolio Arianna Cassetti Mariarosaria Miloso Simona Collina 《Molecules (Basel, Switzerland)》2021,26(21)
Multiple Myeloma (MM) is an aggressive tumor causing millions of deaths every year and currently available therapies are often unsuccessful or correlated with severe side effects. In our previous work we demonstrated that the Hibiscus sabdariffa hydroalcoholic extract inhibits the growth of the MM cell line and we isolated two metabolites responsible for the activity: Hib-ester and Hib-carbaldehyde. Herein we report their interaction with proteasome, one of the main targets in the fight against MM. The molecular modelling study outlined a good interaction of both compounds with the target and these results prompted us to investigate their potential to inhibit proteasome. Metabolites were then isolated from the calyces and an extract with a high content of Hib-ester and Hib-carbaldehyde was prepared. An anticancer profile was drawn, evaluating apoptosis, autophagy and proteasome inhibition, with the anticancer properties being mainly attributed to the Hib-ester and Hib-carbaldehyde, while the proteasome inhibition of the extract could also be ascribed to the presence of anthocyanins, a class of secondary metabolites already known for their proteasome inhibitory activity. 相似文献