Rossinone-related meroterpenes from the Antarctic ascidian Aplidium fuegiense

The chemical analysis of the ascidian Aplidium fuegiense resulted in the isolation of three novel meroterpenoids 2–4, structurally related to the main co-occurring known rossinone B (1). The structures of the new compounds were determined by interpretation of spectroscopic data. Compounds 1–4 were found to be selectively localized in the viscera of the ascidian.     

An Extensive Assessment of Network Embedding in PPI Network Alignment

Network alignment is a fundamental task in network analysis. In the biological field, where the protein–protein interaction (PPI) is represented as a graph, network alignment allowed the discovery of underlying biological knowledge such as conserved evolutionary pathways and functionally conserved proteins throughout different species. A recent trend in network science concerns network embedding, i.e., the modelling of nodes in a network as a low-dimensional feature vector. In this survey, we present an overview of current PPI network embedding alignment methods, a comparison among them, and a comparison to classical PPI network alignment algorithms. The results of this comparison highlight that: (i) only five network embeddings for network alignment algorithms have been applied in the biological context, whereas the literature presents several classical network alignment algorithms; (ii) there is a need for developing an evaluation framework that may enable a unified comparison between different algorithms; (iii) the majority of the proposed algorithms perform network embedding through matrix factorization-based techniques; (iv) three out of five algorithms leverage external biological resources, while the remaining two are designed for domain agnostic network alignment and tested on PPI networks; (v) two algorithms out of three are stated to perform multi-network alignment, while the remaining perform pairwise network alignment.     

Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity

Natural polyamines (PAs) are involved in the processes of proliferation and differentiation of cancer cells. Lipophilic synthetic polyamines (LPAs) induce the cell death of various cancer cell lines. In the current paper, we have demonstrated a new method for synthesis of LPAs via the multicomponent Ugi reaction and subsequent reduction of amide groups by PhSiH₃. The anticancer activity of the obtained compounds was evaluated in the A-549, MCF7, and HCT116 cancer cell lines. For the first time, it was shown that the anticancer activity of LPAs with piperazine fragments is comparable with that of aliphatic LPAs. The presence of a diglyceride fragment in the structure of LPAs appears to be a key factor for the manifestation of high anticancer activity. The findings of the study strongly support further research in the field of LPAs and their derivatives.     

Control problems for energy harvester model and interpolation in Hardy space

Three control problems for the system of two coupled differential equations governing the dynamics of an energy harvesting model are studied. The system consists of the equation of an Euler–Bernoulli beam model and the equation representing the Kirchhoff's electric circuit law. Both equations contain coupling terms representing the inverse and direct piezoelectric effects. The system is reformulated as a single evolution equation in the state space of 3-component functions. The control is introduced as a separable forcing term $\text{◂⋅▸}\mathbf{g}(x)f(t)$ on the right-hand side of the operator equation. The first control problem deals with an explicit construction of $f(t)$ that steers an initial state to zero on a time interval [0, T]. The second control problem deals with the construction of $f(t)$ such that the voltage output is equal to some given function $\mathbf{v}(t)$ (with $\mathbf{g}(x)$ being given as well). The third control problem deals with an explicit construction of both the force profile, $\mathbf{g}(x)$, and the control, $f(t)$, which generate the desired voltage output $\mathbf{v}(t)$. Interpolation theory in the Hardy space of analytic functions is used in the solution of the second and third problems.     

Electronic structure of 4H-pyrido[1,2-a]pyrimidin-4-ones

The characteristic features of ir and uv spectra of 43 4H-pyrido[1,2-a]pyrimidin-4-one derivatives with electron donor or acceptor groups in position 3, and positions 6, 7, 8, or 9, respectively, have been systematically studied. On the basis of the spectra some conclusions have been drawn for the molecular structure. The negative solvent effect of the lowest-energy π → π* transition is investigated by the PPP method.     

Basis property of eigenfunctions of nonselfadjoint operator pencils generated by the equation of nonhomogeneous damped string

We consider a class of nonselfadjoint quadratic operator pencils generated by the equation, which governs the vibrations of a string with nonconstant bounded density subject to viscous damping with a nonconstant damping coefficient. These pencils depend on a complex parameterh, which enters the boundary conditions. Depending on the values ofh, the eigenvalues of the above pencils may describe the resonances in the scattering of elastic waves on an infinite string or the eingenmodes of a finite string. We obtain the 7asymptotic representations for these eigenvalues. Assuming that the proper multiplicity of each eigenvalue is equal to one, we prove that the eigenfunctions of these pencils form Riesz bases in the weightedL ²-space, whose weight function is exactly the density of the string. The general case of multiple eigenvalues will be treated in another paper, based on the results of the present work.     

Asymptotic analysis of nonselfadjoint operators generated by coupled Euler‐Bernoulli and Timoshenko beam model

In the current paper, we present a series of results on the asymptotic and spectral analysis of coupled Euler‐Bernoulli and Timoshenko beam model. The model is well‐known in the different branches of the engineering sciences, such as in mechanical and civil engineering (in modelling of responses of the suspended bridges to a strong wind), in aeronautical engineering (in predicting and suppressing flutter in aircraft wings, tails, and control surfaces), in engineering and practical aspects of the computer science (in suppressing bending‐torsional flutter of a new generation of hard disk drives, which is expected to pack high track densities (20,000+TPI) and rotate at very high speeds (25,000+RPM)), in medical science (in bio mechanical modelling of bloodcarrying vessels in the body, which are elastic and collapsible). The aforementioned mathematical model is governed by a system of two coupled differential equations and a two parameter family of boundary conditions representing the action of the self‐straining actuators. This linear hyperbolic system is equivalent to a single operator evolution equation in the energy space. That equation defines a semigroup of bounded operators and a dynamics generator of the semigroup is our main object of interest. We formulate and proof the following results: (a) the dynamics generator is a nonselfadjoint operator with compact resolvent from the class ??p with p > 1; (b) precise spectral asymptotics for the two‐branch discrete spectrum; (c) a nonselfadjoint operator, which is the inverse of the dynamics generator, is a finite‐rank perturbation of a selfadjoint operator. The latter fact is crucial for the proof that the root vectors of the dynamics generator form a complete and minimal set. In our forthcoming paper, we will use the spectral results to prove that the dynamics generator is Riesz spectral, which will allow us to solve several boundary and distributed controllability problems via the spectral decomposition method. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)