全文获取类型
收费全文 | 726篇 |
免费 | 26篇 |
国内免费 | 2篇 |
专业分类
化学 | 503篇 |
晶体学 | 5篇 |
力学 | 13篇 |
数学 | 92篇 |
物理学 | 141篇 |
出版年
2023年 | 8篇 |
2022年 | 10篇 |
2021年 | 13篇 |
2020年 | 19篇 |
2019年 | 14篇 |
2018年 | 15篇 |
2017年 | 17篇 |
2016年 | 31篇 |
2015年 | 29篇 |
2014年 | 24篇 |
2013年 | 46篇 |
2012年 | 49篇 |
2011年 | 57篇 |
2010年 | 27篇 |
2009年 | 33篇 |
2008年 | 35篇 |
2007年 | 27篇 |
2006年 | 40篇 |
2005年 | 47篇 |
2004年 | 31篇 |
2003年 | 19篇 |
2002年 | 26篇 |
2001年 | 18篇 |
2000年 | 9篇 |
1999年 | 10篇 |
1998年 | 10篇 |
1997年 | 7篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1985年 | 2篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1966年 | 2篇 |
1963年 | 2篇 |
1958年 | 2篇 |
排序方式: 共有754条查询结果,搜索用时 15 毫秒
101.
Mari S. Karthikeyan Bantwal S. Holla Shalini Shenoy 《Monatshefte für Chemie / Chemical Monthly》2008,139(6):707-716
2,4-Dichloro-5-fluorophenyl containing 7-arylidenetriazolothiadiazines were obtained by the reaction of 4-amino-3-(2,4-dichloro-5-fluorophenyl)-5-mercapto-1,2,4-triazole
with 2,3-dibromo-1,3-diarylpropan-1-ones, and also by the reaction of 4-amino-3-(2,4-dichloro-5-fluorophenyl)-5-mercapto-1,2,4-triazole
with α-bromopropenones in the presence of a base. The structure of the 7-arylidenetriazolothiadiazines was confirmed by an
alternative synthesis. A plausible mechanism for the formation of 7-arylidenetriazolothiadiazines is proposed. All newly synthesized
compounds were screened for their analgesic and antimicrobial activities. Compounds bearing 4-chlorophenyl or 3,4-methylenedioxyphenyl
moieties at position 7 of the arylidenetriazolothiadiazines showed excellent analgesic activity. Arylidenetriazolothiadiazines
carrying a phenyl, 4-chlorophenyl, 4-methylphenyl, 3,4-dimethoxyphenyl, and 2,4-dichlorophenyl moieties at position 7 showed
excellent antibacterial and antifungal activities.
Correspondence: Mari Sithambaram Karthikeyan, Department of Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka,
India. 相似文献
102.
Catherine P. Raptopoulou Athanassios K. Boudalis Katerina N. Lazarou Vassilis Psycharis Nikos Panopoulos Michael Fardis George Diamantopoulos Jean-Pierre Tuchagues Alain Mari George Papavassiliou 《Polyhedron》2008,27(18):3575-3586
The use of salicylaldehyde oxime (H2salox) in manganese(III) carboxylate chemistry has yielded new members of the family of hexanuclear compounds presenting the [Mn6(μ3-O)2(μ2-OR)2]12+ core, complexes [MnIII6(μ3-O)2(O2CPh)2(salox)6(L1)2(L2)2] (L1 = py, L2 = H2O (1); L1 = Me2CO, L2 = H2O (2); L1 = L2 = MeOH (3)). Addition of NaOMe to the acetonitrile reaction mixture, afforded the 1D complex [MnIII3Na(μ3-O)(O2CPh)2(salox)3(MeCN)]n (4), whereas addition of NaClO4 to the acetone reaction mixture afforded an analogous 1D complex [MnIII3Na(μ3-O)(O2CPh)2(salox)3(Me2CO)]n (5). The structures of 1–3 present the [Mn6(μ3-O)2(μ2-OR)2]12+ core and can be described as two [Mn3(μ3-O)]7+ triangular subunits linked by two μ2-oximato oxygen atoms of the salox2− ligands, which show the less common μ3-κ2O:κO′:κN coordination mode. The benzoato ligands are coordinated through the usual syn,syn-μ2-κO:κO′ mode. The 1D polymeric structures of 4 and 5 consist of alternating [Mn3(μ3-O)]7+ subunits and Na+ atoms linked through two μ3-κ2O:κO′:κN and one μ4-κ2O:κ2O′:κN salox2− ligands as well as one syn,anti-μ2-κO:κO′ benzoato ligand. DC and AC magnetic susceptibility studies on 1 revealed the stabilization of an S = 4 ground state, and indications of single-molecule magnetism behavior, whereas the DC experimental data from polycrystalline sample of 5 are indicative of antiferromagnetic interactions within the [Mn3] subunit. Solid state 1H NMR data of 1 were used to probe the spin-lattice relaxation of the system. 相似文献
103.
Frederick Trinh Tan Milan Mari? James A. Nicell 《Polymer Degradation and Stability》2008,93(8):1479-1485
The aerobic biological degradation of the synthetic aliphatic-aromatic co-polyester Ecoflex™ (BASF) by 29 strains of enzyme-producing soil bacteria, fungi and yeasts was investigated at moderate environmental conditions. Previous studies had shown that these materials could be degraded but these studies were done under thermophilic conditions. In this paper, a screening procedure was developed to assess the biodegradability of the co-polyester at ambient environmental conditions and to investigate the mechanism of biodegradation. Results showed that the aliphatic-aromatic co-polyester could be degraded by a number of different microorganisms. However, after 21 days exposure to even the most promising cultures of pure microorganisms, only partial degradation of the Ecoflex™ was accomplished and only a few samples showed visible signs of degradation as loosely defined by the mechanical weakening of the films. Weight loss was not as obvious as the visual degradation and suggested broader types of microbial attack. The bacteria studied preferentially degraded the bonds between aliphatic components of the copolymer and the rate of biodegradation of oligomers was appreciably faster than that for the polymer chains. Using GC-MS techniques, degradation intermediates were identified to be the monomers of the co-polyester. Gel permeation chromatography results suggested exo-enzyme type degradation, where the microbes hydrolysed the ester bonds at the termini of the polymeric chains preferentially. 相似文献
104.
Immacolata Speciale Flaviana Di Lorenzo Valentina Gargiulo Gitte Erbs Mari‐Anne Newman Antonio Molinaro Cristina De Castro 《Angewandte Chemie (International ed. in English)》2020,59(16):6368-6374
The lipopolysaccharide (LPS) O‐antigen structure of the plant pathogen Rhizobium radiobacter strain TT9 and its possible role in a plant‐microbe interaction was investigated. The analyses disclosed the presence of two O‐antigens, named Poly1 and Poly2. The repetitive unit of Poly2 constitutes a 4‐α‐l ‐rhamnose linked to a 3‐α‐d ‐fucose residue. Surprisingly, Poly1 turned out to be a novel type of biopolymer in which the repeating unit is formed by a monosaccharide and an amino‐acid derivative, so that the polymer has alternating glycosidic and amidic bonds joining the two units: 4‐amino‐4‐deoxy‐3‐O‐methyl‐d ‐fucose and (2′R,3′R,4′S)‐N‐methyl‐3′,4′‐dihydroxy‐3′‐methyl‐5′‐oxoproline). Differently from the O‐antigens of LPSs from other pathogenic Gram‐negative bacteria, these two O‐antigens do not activate the oxidative burst, an early innate immune response in the model plant Arabidopsis thaliana, explaining at least in part the ability of this R. radiobacter strain to avoid host defenses during a plant infection process. 相似文献
105.
106.
107.
108.
Beverina L Crippa M Landenna M Ruffo R Salice P Silvestri F Versari S Villa A Ciaffoni L Collini E Ferrante C Bradamante S Mari CM Bozio R Pagani GA 《Journal of the American Chemical Society》2008,130(6):1894-1902
Singlet oxygen sensitization by organic molecules is a topic of major interest in the development of both efficient photodynamic therapy (PDT) and aerobic oxidations under complete green chemistry conditions. We report on the design, synthesis, biology, and complete spectroscopic characterization (vis-NIR linear and two-photon absorption spectroscopy, singlet oxygen generation efficiencies for both one- and two-photon excitation, electrochemistry, intrinsic dark toxicity, cellular uptake, and subcellular localization) of three classes of innovative singlet oxygen sensitizers pertaining to the family of symmetric squaraine derivatives originating from pi-excessive heterocycles. The main advantage of pi-extended squaraine photosensitizers over the large number of other known photosensitizers is their exceedingly strong two-photon absorption enabling, together with sizable singlet oxygen sensitization capabilities, for their use at the clinical application relevant wavelength of 806 nm. We finally show encouraging results about the dark toxicity and cellular uptake capabilities of water-soluble squaraine photosensitizers, opening the way for clinical small animal PDT trials. 相似文献
109.
Kanna Adachi Tomoshi Yamada Hayate Ishizuka Mana Oki Shunsuke Tsunogae Noriko Shimada Osamu Chiba Tatsuya Orihara Prof. Dr. Masafumi Hidaka Prof. Dr. Takatsugu Hirokawa Dr. Minami Odagi Prof. Dr. Keiichi Konoki Prof. Dr. Mari Yotsu-Yamashita Prof. Dr. Kazuo Nagasawa 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(9):2025-2033
A novel series of C12-keto-type saxitoxin (STX) derivatives bearing an unusual nonhydrated form of the ketone at C12 has been synthesized, and their NaV-inhibitory activity has been evaluated in a cell-based assay as well as whole-cell patch-clamp recording. Among these compounds, 11-benzylidene STX ( 3 a ) showed potent inhibitory activity against neuroblastoma Neuro 2A in both cell-based and electrophysiological analyses, with EC50 and IC50 values of 8.5 and 30.7 nm , respectively. Interestingly, the compound showed potent inhibitory activity against tetrodotoxin-resistant subtype of NaV1.5, with an IC50 value of 94.1 nm . Derivatives 3 a – d and 3 f showed low recovery rates from NaV1.2 subtype (ca 45–79 %) compared to natural dcSTX ( 2 ), strongly suggesting an irreversible mode of interaction. We propose an interaction model for the C12-keto derivatives with NaV in which the enone moiety in the STX derivatives 3 works as Michael acceptor for the carboxylate of Asp1717. 相似文献
110.
Mária Hvastijová Jiri Kohout Marián Okruhlica Jerzy Mroziński Lothar Jäger 《Transition Metal Chemistry》1993,18(6):579-582
Summary Dicyanamide complexes of CuII, NiII and CoII of the type M[N(CN)2]2L2, where L = benzimidazole, 2-methyl- or 2-ethylbenzimidazole, have been prepared and studied by spectroscopy and magnetochemistry. The complexes, except for Co[N(CN)2]2 (benzimidazole)2, are six-coordinate, involving bidentate bridging dicyanamide groups. While the NiII complexes have practically octahedral structures, the CuII complexes are pseudooctahedral with similar tetragonal distortion. The ligand field strength in these complexes depends mainly on the steric effect of the benzimidazole ligands. The CoII complex of benzimidazole is monomeric tetrahedral, but that of 2-ethylbenzimidazole is tetragonal octahedral. The oridging function of dicyanamide in the six-coordinate complexes is realized either through both cyanide or through amide and cyanide nitrogens. The complex Cu[N(CN)2]2 (2-methylbenzimidazole)2 is a weak antiferromagnet (J = -0.1 cm–1), exhibiting under ca. 15 K a long-range antiferromagnetic ordering. 相似文献