Focused ion beam sectioning and lift-out method for copper and resist vias in organic low-k dielectrics.

The focused ion beam lift-out technique for scanning electron microscope (SEM) and transmission electron microscope (TEM) sample preparation was shown to be applicable to copper/low-k dielectric semiconductor technology. High resolution SEM, TEM, and scanning transmission electron microscope analyses were performed on metal contacts and resist vias with no evidence of the interface damage or metal smearing commonly observed with mechanical polishing. Ion milling of the sample ex situ to the substrate provided decoration and adjustment of the exposed plane of the section when necessary for SEM analysis.     

Stereoselective Synthesis of Sialyl Lewisa Antigen and the Effective Anticancer Activity of Its Bacteriophage Qβ Conjugate as an Anticancer Vaccine

Sialyl Lewis^a (sLe^a), also known as cancer antigen 19-9 (CA19-9), is a tumor-associated carbohydrate antigen. The overexpression of sLe^a on the surface of a variety of cancer cells makes it an attractive target for anticancer immunotherapy. However, sLe^a-based anticancer vaccines have been under-explored. To develop a new vaccine, efficient stereoselective synthesis of sLe^a with an amine-bearing linker was achieved, which was subsequently conjugated with a powerful carrier bacteriophage, Qβ. Mouse immunization with the Qβ-sLe^a conjugate generated strong and long-lasting anti-sLe^a IgG antibody responses, which were superior to those induced by the corresponding conjugate of sLe^a with the benchmark carrier keyhole limpet hemocyanin. Antibodies elicited by Qβ-sLe^a were highly selective toward the sLe^a structure, could bind strongly with sLe^a-expressing cancer cells and human pancreatic cancer tissues, and kill tumor cells through complement-mediated cytotoxicity. Furthermore, vaccination with Qβ-sLe^a significantly reduced tumor development in a metastatic cancer model in mice, demonstrating tumor protection for the first time by a sLe^a-based vaccine, thus highlighting the significant potential of sLe^a as a promising cancer antigen.     

Synthesis and characterization of polyimides with ether linkages

Thermoplastic and thermoset polyimides derived from 2,2-bis[4-(4-aminophenoxy)phenyl]propane (BAPP) and 4,4′-bis(4-aminophenoxy)-2,2′-dimethylbiphenyl (BAPD) were prepared and characterized. Their physical and thermal properties as well as the polyelectrolyte effect exhibited by BTDA–BAPP polyamic acids in NMP solution were discussed. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2559–2567, 1999     

Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical,polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles

Highly functionalized pyrroles with appropriate regiochemical functionality represent an important class of marine natural products and potential drug candidates. We describe herein a detailed study of the reaction of α-aminoacid esters with vinylogous amides and also β-halovinylaldehydes for the regiospecific synthesis of 2,3,4-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles. Since the vinylogous amides and β-halovinylaldehydes are readily available precursors, rapid access to a wide variety of unsymmetrically substituted pyrroles is accomplished via this methodology.     

A model to set measurement quality objectives and to establish measurement uncertainty expectations in analytical chemistry laboratories using ASTM proficiency test data

A model is presented that correlates historical proficiency test data as the log of interlaboratory standard deviations versus the log of analyte concentrations, independent of analyte (measurand) or matrix. Analytical chemistry laboratories can use this model to set their internal measurement quality objectives and to apply the uncertainty budget process to assign the maximum allowable variation in each major step in their bias-free measurement systems. Laboratories that are compliant with this model are able to pass future proficiency tests and demonstrate competence to laboratory clients and ISO 17025 accreditation bodies. Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/ 10.1007/s007690100398-y. Received: 31 March 2001 Accepted: 11 September 2001     

Polarization-selective switching in holographically formed polymer dispersed liquid crystals

We have developed an optical stack of holographically formed polymer dispersed liquid-crystal (H-PDLC) devices that is fully operational with nonpolarized light sources. The device consists of two H-PDLC transmission gratings separated by a passive polarization rotator that can output a diffracted s-polarized, p-polarized, or s- and p-polarized beam simultaneously.     

Cold compaction of polymeric powders in tapered dies

Tests involving the cold compaction of four polymeric powders in circular section tapered dies were carried out to study the force transmitted through the powders. It was found that the decreasing cross-sectional area could be used to compensate for the force loss in order to keep the transmitted pressure high but the effect was not as large as had been anticipated. The optimum angle of taper was found to be in the region of 75 to 80°. A mathematical model was developed for the compaction of plastic powders in tapered dies. It was found that an equation of the type

could be used to prodict the transmitted pressured in a tapered die from a knowledge of the compaction characteristics for a cylindrical die.     

Q value of the superallowed decay of 46V and its influence on Vud and the unitarity of the Cabibbo-Kobayashi-Maskawa matrix

The masses of the radioactive nuclei (46)V and its decay daughter (46)Ti have been measured with the Canadian Penning Trap on-line Penning trap mass spectrometer to a precision of 1 x 10(-8). A Q(EC) value of 7052.90(40) keV for the superallowed beta decay of (46)V is obtained from the difference of these two masses. With this precise Q value, the Ft value for this decay is determined with improved precision. An investigation of an earlier Q-value measurement for (46)V uncovers a set of 7 measurements that cannot be reconciled with modern data and affects previous evaluations of V(ud) from superallowed Fermi decays. A new evaluation, adding our new data and removing the discredited subset, yields new values for G(V) and V(ud). When combined with recent results for V(us), this yields modified constraints for the unitarity of the Cabibbo-Kobayashi-Maskawa matrix and other extensions of the standard model.     

Cross sections and transverse single-spin asymmetries in forward neutral-pion production from proton collisions at sqrt[s]=200 GeV

Measurements of the production of forward high-energy pi(0) mesons from transversely polarized proton collisions at sqrt[s]=200 GeV are reported. The cross section is generally consistent with next-to-leading order perturbative QCD calculations. The analyzing power is small at x(F) below about 0.3, and becomes positive and large at higher x(F), similar to the trend in data at sqrt[s]< or =20 GeV. The analyzing power is in qualitative agreement with perturbative QCD model expectations. This is the first significant spin result seen for particles produced with p(T)>1 GeV/c at a polarized proton collider.     

Azimuthal anisotropy and correlations at large transverse momenta in p + p and Au + Au collisions at square root sNN=200 GeV

Results on high transverse momentum charged particle emission with respect to the reaction plane are presented for Au + Au collisions at square root s(NN)=200 GeV. Two- and four-particle correlations results are presented as well as a comparison of azimuthal correlations in Au + Au collisions to those in p + p at the same energy. The elliptic anisotropy v(2) is found to reach its maximum at p(t) approximately 3 GeV/c, then decrease slowly and remain significant up to p(t) approximately 7-10 GeV/c. Stronger suppression is found in the back-to-back high-p(t) particle correlations for particles emitted out of plane compared to those emitted in plane. The centrality dependence of v(2) at intermediate p(t) is compared to simple models based on jet quenching.