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31.
Isabela P. Veronez Josiane S. P. Daniel Jerusa S. Garcia Marcello G. Trevisan 《Journal of Thermal Analysis and Calorimetry》2014,115(3):2407-2414
Desloratadine (DL) is a selective antagonist of the histamine H1 receptor, which has been widely used to treat allergic symptoms, and stands out from other drugs in this therapeutic class because it does not cause sedative effects. In the present study, the physico-chemical properties of DL were fully characterized using six analytical techniques such as Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TG/DTG), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, Powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). The DSC curve shows a sharp endothermic event at 158.4 °C, and the TG/DTG curve presents two decomposition events between 178.4 and 451.9 °C. A compatibility study involving DL and nine pharmaceutical excipients generally used in pharmaceutical formulations was performed. Physical binary mixtures of DL with each excipient were prepared in a 1:1 (w/w) ratio. After preparation, the samples were analyzed immediately and the results reveal solid-state interaction with anhydrous lactose, microcrystalline cellulose, magnesium stearate, and stearic acid. 相似文献
32.
Macarena Eugui Katerine Rasquin Andrés López Radcenco Leopoldo Suescun Guillermo Moyna 《Tetrahedron letters》2018,59(16):1560-1563
We describe a novel pericyclic/anionic cascade reaction on tropolonic substrates that combines a Diels-Alder reaction, an oxa-Michael addition, and an acyloin rearrangement to afford tricyclic α-hydroxy-β-methoxyketones. Spectroscopic, crystallographic, and mechanistic studies indicate that the process requires stabilization of reaction intermediates through intramolecular H-bonding to take place, and suggest that the conjugate addition step involves a catalytic cycle with initial formation of an ammonium enolate and sustained by an alkoxide ion pair. Given the rich functionality and structural complexity generated in a single step, the process could be exploited in the preparation of natural product-like compound libraries. 相似文献
33.
Pártay LB Sega M Jedlovszky P 《Langmuir : the ACS journal of surfaces and colloids》2007,23(24):12322-12328
The relative arrangement of the neighboring bile ions and the shape of the hydrophobic and hydrogen-bonded primary micelles as well of the large secondary micelles formed by these ions are analyzed in detail on the basis of molecular dynamics computer simulations of 30 and 300 mM sodium cholate and sodium deoxycholate solutions. In the lower concentration considered, the systems only contain primary micelles, whereas in both of the 300 mM systems secondary micelles are also present. The simulations performed were long enough that the systems reached thermodynamic equilibrium. It is found that the neighboring cholate ions prefer alignments in which their quasi-planar tetracyclic ring systems are parallel with each other, whereas for deoxycholate an opening of the angle between these planes is observed. The shape of the micelles is characterized by the ratio of their three principal moments of inertia. The primary deoxycholate micelles are found to be rather spherical, whereas in the case of cholate somewhat flattened, disklike or oblate shaped ellipsoidal primary micelles are found, irrespective of whether these micelles are kept together by hydrogen bonds or are of hydrophobic origin. Finally, the secondary micelles are found to exhibit a large variety of shapes, ranging from flattened oblates to rodlike objects through various different irregular shapes, characterized by markedly different values of the three principal moments of inertia. The observed preferences of the relative arrangement of the neighboring ions and of the aggregate shapes as well as the differences observed in the behavior of the two bile ions studied in these respects are traced back to the molecular structure of these ions. 相似文献
34.
Aliphatic and aromatic amines are efficiently acylated by acetic, pivalic, benzoic, phthalic, or maleic anhydrides in ethyl acetate at room temperature. Under the same experimental conditions, amino alcohols are chemoselectively acylated at the amino group. 相似文献
35.
Tiecco M Testaferri L Santi C Tomassini C Marini F Bagnoli L Temperini A 《Chemistry (Weinheim an der Bergstrasse, Germany)》2002,8(5):1118-1124
The synthesis of the new chiral non-racemic sulfur-containing diselenide, di-2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl diselenide, is described. When treated with ammonium persulfate this diselenide is transformed into the corresponding selenenyl sulfate, which acts as a strong electrophilic reagent and adds to alkenes, in the presence of methanol or water, to afford the products of selenomethoxylation or selenohydroxylation, respectively, with excellent diastereoselectivities. Starting from alkenes containing internal nucleophiles, asymmetric cyclofunctionalization reactions also resulted in good chemical yields, complete regioselectivities, and high diastereoselectivities. This sulfur-containing diselenide can also be used in catalytic amounts to promote one-pot selenenylation-deselenenylation processes, from which several types of products can be obtained in high yield and with good enantiomeric excess. 相似文献
36.
The phytochemical study of aerial parts of Viburnum sargenti Koehne, a species spontaneous in Mongolia and Northern China, led to the isolation of three iridoid glucosides of Valeriana-type: the novel 7,10,2'-triacetylsuspensolide F, 1, and the known viburtinoside IV and V. In addition, (+)-epicatechin was also isolated. 相似文献
37.
Agnello M Beer G Benussi L Bertani M Bianco S Botta E Bressani T Busso L Calvo D Camerini P Cerello P Dalena B De Mori F D'Erasmo G Di Santo D Fabbri FL Faso D Feliciello A Filippi A Filippini V Fiore EM Fujioka H Gianotti P Grion N Lucherini V Marcello S Maruta T Mirfakhrai N Morra O Nagae T Olin A Outa H Pace E Palomba M Pantaleo A Panzarasa A Paticchio V Piano S Pompili F Rui R Simonetti G So H Tomassini S Toyoda A Wheadon R Zenoni A;FINUDA Collaboration 《Physical review letters》2005,94(21):212303
We have searched for a deeply bound kaonic state by using the FINUDA spectrometer installed at the e(+)e(-) collider DAPhiNE. Almost monochromatic K(-)'s produced through the decay of phi(1020) mesons are used to observe K(-) absorption reactions stopped on very thin nuclear targets. Taking this unique advantage, we have succeeded to detect a kaon-bound state K(-)pp through its two-body decay into a Lambda hyperon and a proton. The binding energy and the decay width are determined from the invariant-mass distribution as 115(+6)(-5)(stat)(+3)(-4)(syst) MeV and 67(+14)(-11)(stat)(+2)(-3)(syst) MeV, respectively. 相似文献
38.
39.
Decleva P Fronzoni G Stener M de Simone M Coreno M Green JC Hazari N Plekan O 《Physical review letters》2005,95(26):263401
Photoemission from the two outermost ionizations [highest occupied molecular orbitals (HOMO and HOMO-1)] of Mg(eta(5)-C(5)H(5))(2) has been studied with synchrotron radiation in the gas phase. Strong oscillations in the HOMO-1/HOMO ratio, qualitatively similar to those well-known for fullerenes, are found. Excellent agreement with the experimental ratio is provided by accurate cross section calculations both at the density-functional theory and time-dependent density-functional theory level, indicating that a many electron response has a minor role for this effect. A comparison with the calculated values for other metal sandwich compounds indicate that the presence of oscillations is a widespread phenomenon, and a potential source of interesting information on the structural and electronic properties of the target molecule. 相似文献
40.