红厚壳属植物化学成份及药理活性研究进展

综述了近年来对红厚壳属植物中的化学成分及药理活性研究，重点讨论了18种 红厚壳属植物中Zhao吨酮类，香豆素类，黄酮类和萜类的化学成分，并讨论了它们 的药理活性。     

Losartan potassium,a non‐peptide agent for the treatment of arterial hypertension

In the title compound, potassium 2‐butyl‐4‐chloro‐1‐{[2′‐(5‐tetrazolido)­bi­phenyl‐4‐yl]­methyl}‐1H‐imidazol‐5‐yl­methanol, K⁺·C₂₂H₂₂ClN₆O^?, the imidazole and tetrazole rings are at angles of 85.0 (2) and 51.8 (1)°, respectively, to the phenyl rings to which they are attached, while the dihedral angle between the latter two rings is 46.7 (1)°. The coordination sphere of the metal cation consists of six tetrazoyl N atoms, the methanol O atom and the π cloud of one of the phenyl rings. These interactions determine the formation of columns of molecular anions that lie parallel to the b axis, while hydrogen bonding contributes to intercolumnar cohesion. Far from the centre of the columns, the hydro­carbon chain is immersed in a hydro­phobic environment.     

Synthese und Kristallstruktur von Blei(II)‐oxidhalogenid‐Alkoholaten mit unterschiedlichen Verknüpfungsvarianten von Pb4O4‐Heterokubaneinheiten

Synthesis and Crystal Structure Determination of Lead(II) Oxide Halide Alcoholates with Different Connectivity of Pb₄O₄ Heterocubane‐like Subunits The reaction of red lead(II) oxide (Litharge) and lead(II) halide (Cl^? and Br^?) with diethylene glycole at a temperature of 180 °C leads to the isotypic compounds [Pb₆(C₄H₈O₃)O₂Cl₆] (1) and [Pb₆(C₄H₈O₃)O₂Br₆] (2) . In a similar synthesis with PbI₂ as educt at temperature of 160 °C the two modifications β‐[Pb₆(C₄H₈O₃)O₂I₆] (3) and α‐[Pb₆(C₄H₈O₃)O₂I₆] (4) were found, whereas at a reaction temperature of 180 °C [Pb₉(C₂H₄O₂)(C₄H₈O₃)O₃I₈] (5) was surprisingly obtained as product. The X‐ray diffraction data show that at a temperature of 180 °C a splitting of the ether took place. The cited compounds show cubane like subunits built by lead and oxygen atoms. These fragments are connected by alkoholate molecules. In 5 additionally an I₆ octahedra centered by lead is observed.     

A new class of isoquinoline alkaloids: The indenobenzazepines

The dark yellow indenobenzazepine alkaloids lahorine ($\text{1}$) and lahoramine ($\text{2}$) have been found in $\text{Fumaria}$$\text{parviflora}$ Lam. (Fumariaceae). In a transformation with biogenetic implications, treatment of the spirobenzylisoquinolines dihydrofumariline ($\text{4}$) and dihydroparfumidine ($\text{7}$) with methanesulfonyl chloride and triethylamine in dry THF, followed by iodine oxidation, provided $\text{1}$ and $\text{2}$, respectively.     

Thermodynamic excess quantities in the adsorption of sodium alkylsulfonates at the air-solution interface

Colloid and Polymer Science - Data on the surface tension of sodium alkylsulfonate solutions at different temperatures and surfactant concentrations are presented. By applying the thermodynamic...     

七-O-乙酰基-β-乳糖异硫氰酸酯的合成、表征及电化学研究

本文合成了并培养出了七-O-乙酰基—β—乳糖异硫氰酸酯的单晶，用X射线衍射分析了其晶体结构。结果表明，晶体为正交晶系，P2₁2₁2₁空间群，a＝1．23282(7)，b＝1．80012(10)，c＝1.85230(10) nm，α＝β＝γ＝90°，V＝4．1107(4) nm³，Z＝4。电化学实验观测到单链DNA和双链DNA对该化合物的峰电流均有明显降低作用，表明化合物与DNA发生了静电作用。     

Neutron activation analysis of final molasses from Cuban sugar industry

Thermal and epithermal non-destructive activation analyses have been performed on samples of final molasses from 14 different sugar factories, covering the most important regions in Cuba. From the first measurement after irradiation at the Triga Mark reactor (VTT), the concentration of more than 15 elements is reported. The almost constant elemental composition shows that they can be used equally for different purposes as animal foodstuff and for the manufacture of biotechnological products. This work is part of a research project developed in order to establish a complete characterization of Cuban sugar molasses.     

Complexation of the Non-steroidal Anti-inflammatory Drug Nabumetone with Modified and Unmodified Cyclodextrins

The inclusion of the anti-inflammatory drug, Nabumetone, in -, - and hydroxypropyl--cyclodextrin (CDs) is studied using UV-VIS absorption and steady-state fluorescence emission. Binding constants and thermodynamic parameters of complex formation are determined by spectrofluorimetry. The inclusion phenomena of Nabumetone with the three cyclodextrins is compared with that of the well known similar anti-inflammatory drug Naproxen. In the case of Nabumetone pronounced differences are observed in the complexation process with each cyclodextrin whereas the respective Naproxen complexes are nearly identical. ¹H-NMR experiments show that the inclusion process in Nabumetone can occur either through the substituents in the -2 (butanone) or -6 (methoxy) positions in the naphthalene ring.     

The first total synthesis of (-)-tamandarin A

[formula: see text] Tamandarin A (1), a newly isolated natural product similar in structure to didemnin B (2), was shown to be somewhat more active in vitro than 2 against pancreatic carcinoma with an ED50 value 1.5 to 2 ng/mL. We report here the first total synthesis of 1. The key steps include a practical stereoselective synthesis of the Hiv-isostatine unit, high-yielding linear precursor formation, a successful macrocyclization, and coupling of the macrocycle with the side chain to afford tamandarin A (1).