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11.
Synthesis of Naphthalene Functionalized Trans‐2,3‐dihydrofuro[3,2‐c]coumarins as Antioxidant and Anthelmintic Agents
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Deepak Wadhwa Varun Arora Loveena Arora Pragi Arora Om Parkash 《Journal of heterocyclic chemistry》2016,53(4):1030-1035
A series of trans‐2,3‐dihydrofuro[3,2‐c]coumarins ( 4 ) has been synthesized by a one‐pot multicomponent reaction by aromatic aldehydes, 4‐hydroxycoumarin, α‐tosyloxyketones, and pyridine using triethylamine as catalysts in acetonitrile. The synthesized compounds were then screened for their antioxidant and anthelmintic activities. 相似文献
12.
A Facile Synthesis of Novel Dihydroindeno[1,2‐e][1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines Using HTIB
Om Prakash Deepak Kumar Aneja Deepak Wadhwa Ravi Kumar Sanjiv Arora 《Journal of heterocyclic chemistry》2012,49(3):566-570
The synthesis of a series of 21 novel 3‐alkyl/aryl‐7/9‐methyl‐10,10a‐dihydroindeno[1,2‐e][1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines ( 4 ) has been achieved by the cyclocondensation between 4/6‐methyl‐2‐tosyloxy‐1‐indanones ( 2 ) and 3‐alkyl/aryl‐4‐amino‐5‐mercapto‐1,2,4‐s‐triazoles ( 3 ). 4/6‐Methyl‐2‐tosyloxy‐1‐indanones ( 2 ) were readily accessible through hypervalent iodine oxidation of 4/6‐methyl‐1‐indanones using [(hydroxy)tosyloxyiodo]benzene (HTIB, Koser's reagent) in acetonitrile. 相似文献
13.
Kandhro GA Kazi TG Baig JA Sirajuddin Afridi HI Shah AQ Sheikh HR Kolachi NF Wadhwa SK 《Journal of AOAC International》2010,93(5):1589-1594
A simple and rapid cloud point extraction method was applied for preconcentration of trace quantities of zinc (Zn) and iron (Fe) in biological samples (serum and urine) of thyroid patients prior to determination by flame atomic absorption spectrometry. The metals in serum and urine samples were complexed with 1-(2-thiazolylazo)-2-naphthol and entrapped in the surfactant octylphenoxypolyethoxyethanol (Triton X-114). After centrifugation, the surfactant-rich phase was diluted with 0.1 M HNO3 in methanol. For optimum recovery of analytes, the influences of the analytical parameters, including pH and amounts of complexing and surfactant reagents, were investigated. Enrichment factors of 66.4 and 70.2 were obtained for the preconcentration of Zn(II) and Fe(III), respectively. The obtained results showed sufficient recoveries (>98%) for Zn(II) and Fe(III) in certified reference materials (CRMs). The proposed method was applied to the determination of Zn(II) and Fe(III) in biological (serum and urine) samples and CRMs. 相似文献
14.
Herein we report that tetrabutylammonium fluoride (TBAF) is a very efficient catalyst for the addition of trialkylsilylalkynes to aldehydes, ketones, and trifluoromethyl ketones in THF solvent at room temperature. The reaction conditions are mild and operationally simple, and a variety of aryl functional groups, such as chloro, trifluoromethyl, bromo, and fluoro groups, are tolerated. Impressively, using our protocol, useful CF(3)-bearing tertiary propargylic alcohols can be synthesized. Product yields are generally better than or comparable to those in the literature. 1-Phenyl-2-trimethylsilyl acetylene, trimethyl ((4-(trifluoromethyl)phenyl)ethynyl)silane, 1-trimethylsilyl-1-hexyne, and trimethyl(thiophen-3-ylethynyl)silane underwent clean conversion to their corresponding propargylic alcohols as products under our conditions. Heterocyclic carbonyl compounds, such as furan-3-carboxaldehyde, thiophene-3-carboxaldehyde, and 2-pyridyl ketone, gave good yields of propargylic alcohols. 相似文献
15.
Souradeep Roy Shalini Nagabooshanam Kushagra Krishna Shikha Wadhwa Nidhi Chauhan Utkarsh Jain Ranjit Kumar Ashish Mathur James Davis 《Electroanalysis》2020,32(9):2082-2089
L‐tyrosine is an amino acid, the concentration of which is found to be highly elevated in patients suffering from diabetic foot ulcer (DFU). The latter proves to be fatal when it turns out chronic and may lead to amputation. The conventional clinical diagnostic methods are costly and time consuming, in which case, the condition of patient(s) may deteriorate long before proper treatment commences. Herein, we report the development of smart band‐aid for real time monitoring of L‐tyrosine by employing enzymatic bio‐sensor using α‐MnO2/tyrosinase. The smart band‐aid was further integrated with portable electronics capable of wireless data transmission to a personal digital assistant, and its tyrosine sensing performance was evaluated. Anodic current was found to vary linearly with the concentrations of L‐tyrosine in the range of 5 nM–500 μM. The developed sensor displayed a limit of detection and sensitivity of 0.71 nM and 0.67 μA/nM/mm2 respectively, with a stability of 25 days. The developed sensor was validated using a commercial impedance analyzer. The impedance response was found to be consistent with the cyclic voltammogram obtained and demonstrated to be a linear function of tyrosine concentration. The developed sensing platform combines early diagnosis with connected health technologies, thus, fitting well into modern healthcare needs. 相似文献
16.
Summary In this paper we consider programming problems in which the constraints are linear and the objective function is the product or the quotient of two functions, each function being a homogeneous form of first degree with a constant added to it.With the proper assumptions of concavity or convexity of the homogeneous forms, this nonlinear programming problem is reduced to that of maximization of a concave function over a convex constraint set.
Prepared with the partial support of the C.S.I.R., India.
Vorgel. v.:J. Nitsche. 相似文献
Zusammenfassung In der vorliegenden Arbeit werden Programme untersucht, bei denen die Nebenbedingungen linear sind und die Zielfunktion als Produkt bzw. Quotient zweier Funktionen darstellbar ist, die bis auf additive Konstanten homogen von 1. Grad sind. Bei geeigneten Konvexitäts- oder Konkavitätsannahmen für diese Funktionen lassen sich solche Programme auf die Maximierung einer konkaven Funktion in einem konvexen Gebiet zurückführen.
Prepared with the partial support of the C.S.I.R., India.
Vorgel. v.:J. Nitsche. 相似文献
17.
Mahajan Priya Wadhwa Bhumika Barik Manas Ranjan Malik Fayaz Nargotra Amit 《Molecular diversity》2020,24(1):45-60
Molecular Diversity - The traditional method of drug discovery process has been surpassed by a rational approach where computer-aided drug designing plays a vital role in the identification of... 相似文献
18.
Kolachi NF Kazi TG Afridi HI Khan S Baig JA Wadhwa SK Shah AQ Shah F 《Journal of AOAC International》2011,94(4):1069-1075
Advanced extraction methods have been developed for direct speciation of dissolved inorganic and organic selenium (Se) species in aqueous extracts of medicinal plants (MPs). The inorganic species of Se (SeIV and SeVI) were separated from organic forms by adsorbing inorganic Se on alumina, while the organic Se was not retained. The retained inorganic Se species was eluted with 10 mL 0.2 M HCl. The total inorganic Se species was determined after prereduction of SeVI into SeIV with concentrated HCl. The SeIV in the eluent and total inorganic Se species were then complexed with diethyldithiocarbamate. The resultant complexes were entrapped in the nonionic surfactant Triton X-114. The total Se, organic Se, total inorganic Se, and SeIV species were determined by electrothermal atomic absorption spectrometry with a modifier. The SeVI concentration was obtained by subtracting SeIV from total inorganic Se contents. The main factors affecting the methodologies were investigated in detail. Under the optimized experimental conditions, the LOD for SeIV was 50 microg/L. Among dissolved inorganic and organic Se species in aqueous extracts of MPs, organic Se species were present in the range of 74-84%, SeIV 3.62-7.47%, and SeVI 12.4-18.57% of total Se contents. 相似文献
19.
Kazi TG Baig JA Shah AQ Kandhro GA Khan S Afridi HI Kolachi NF Wadhwa SK Shah F Baig AM 《Journal of AOAC International》2011,94(1):293-299
A simple and rapid cloud point extraction (CPE) procedure was applied for preconcentration of trace quantities of arsenic (As) in scalp hair samples. The samples were subjected to microwave-assisted digestion in a mixture of nitric acid and hydrogen peroxide (2 + 1, v/v) prior to preconcentration by CPE. The As in digested samples was complexed with ammonium pyrrolidine dithiocarbamate (APDC), and the resultant As-PDC complex was extracted by a nonionic surfactant, octylphenoxypolyethoxyethanol (Triton X-114). After centrifugation, the surfactant-rich phase was diluted with 0.1 M HNO3 in methanol and analyzed by electrothermal atomic absorption spectrometry. The experimental parameters, i.e., amount of APDC, concentration of Triton X-114, equilibrium temperature and time, were optimized. For validation of the proposed method, a certified reference material (CRM) of human hair (BCR 397) was used. No significant difference (P > 0.05) was observed between the experimental results and certified values of the CRM (paired t-test). The LOD and LOQ obtained under the optimal conditions were 0.025 and 0.083 microg/kg, respectively. The developed method was applied for the determination of As in scalp hair samples from male and female subjects of two villages of Khairpur Mir's, Pakistan. 相似文献
20.
Facile synthesis of furo[3,2-c]coumarins (2a–g) via cyclocondensation of 4-hydroxycoumarin and α-tosyloxyketones (1a–g) is described. A plausible mechanism involving C-C bond formation followed by 5-exo-tet cyclization is suggested. 相似文献