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排序方式: 共有196条查询结果,搜索用时 31 毫秒
41.
42.
Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non‐human Primates
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Jing Xu Prof. Dr. Mengxiao Yu Chuanqi Peng Phoebe Carter Jia Tian Xuhui Ning Qinhan Zhou Qiu Tu Greg Zhang Anthony Dao Xingya Jiang Prof. Dr. Payal Kapur Prof. Dr. Jer‐Tsong Hsieh Prof. Dr. Xudong Zhao Prof. Dr. Pengyu Liu Prof. Dr. Jie Zheng 《Angewandte Chemie (International ed. in English)》2018,57(1):266-271
While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the understandings of potential dose‐dependent in vivo transport of nanomedicines. Here we report that the pharmacokinetics and clearance of renal clearable gold nanoparticles (GS‐AuNPs) are strongly dose‐dependent once injection doses are above 15 mg kg?1: high dose expedited the renal excretion and shortened the blood retention. As a result, the no‐observed‐adverse‐effect‐level (NOAEL) of GS‐AuNPs was >1000 mg kg?1 in CD‐1 mice. The efficient renal clearance and high compatibility can be translated to the non‐human primates: no adverse effects were observed within 90 days after intravenous injection of 250 mg kg?1 GS‐AuNPs. These fundamental understandings of dose effect on the in vivo transport of ultrasmall AuNPs open up a pathway to maximize their biomedical potentials and minimize their toxicity in the future clinical translation. 相似文献
43.
L. C. Anand A. B. Deshpande S. L. Kapur 《Journal of polymer science. Part A, Polymer chemistry》1967,5(3):665-673
The rate of polymerization with the VOCl3–AlEt2Br catalyst system at 30°C. in n-hexane reached a maximum at an Al/V molar ratio of 1.5. At this ratio, the rate of polymerization was first-order with respect to catalyst and second-order with respect to monomer concentrations. The apparent activation energy calculated was 6.4 kcal./mole. Diethylzine was found to act as a chain transfer agent. However, the molecular weights of polymers obtained were low. The possibility of bromide-containing catalyst sites acting in the termination reaction has been investigated. The average valence of vanadium is discussed in relation to molecular weights. 相似文献
44.
All-carbon 1,3-dipoles derived from allenic esters/ketones, by catalytic interaction with triphenylphosphine, undergo an unusual [8 + 2] annelation with tropone, leading to 8-oxa-9-(ethoxycarbonyl/acylalkylidene)bicyclo[5.3.0]deca-1,3,5-trienes. Dipoles derived from allenic ketones as well as an alpha-methyl-substituted allenic ester display high reactivity and selectivity. 相似文献
45.
A. B. Deshpande R. V. Subramanian S. L. Kapur 《Journal of polymer science. Part A, Polymer chemistry》1967,5(4):761-767
Polymerization of isoprene in presence of a heterogeneous Ziegler-type catalyst system, Cr(AcAc)3–AlEt3, has been studied in benzene medium. The rate of polymerization is first-order with respect to catalyst as well as monomer concentration. The rate studies, activation energy, and polymer microstructures are reported in order to follow the probable mechanism of polymerization. 相似文献
46.
A. B. Deshpande C. R. Rajan S. L. Kapur 《Journal of polymer science. Part A, Polymer chemistry》1973,11(6):1317-1320
Vanadium-based catalyst complexes prepared in the presence of monomers have been used for the copolymerization of styrene and acrylonitrile. VOCl3–Al(i-C4H9)3 catalyst system seems to yield an alternating copolymer. The copolymers are easily soluble in DMF and have low softening points. 相似文献
47.
A. Kumar J. V. Sonawane N. S. Rathore H. N. Kapur A. K. Venugopalan D. D. Bajpai 《Journal of Radioanalytical and Nuclear Chemistry》2002,254(3):469-478
Partitioning of minor alpha-emitting actinides, especially U, Pu and Am from medium active alkaline waste is possible from intermediate level liquid wastes (ILLW) produced during spent fuel reprocessing following Purex process. This paper deals with the efficient removal of alpha-activity from ILLW by solvent extraction process. Counter current batch extraction with O/A ratio 2:1 as well as multistage mixer settler has demonstrated that most of the alpha-activity was removed from the alkaline effluents using 20% Versatic-10 (V-10) in dodecane after giving 3 to 4 contacts, thus converting alkaline waste as non-alpha waste. Under the optimum conditions (pH 9.0-9.5 and VA-10), both Pu(IV) and Am(III) are highly extractable whereas U(VI) is relatively poorly extracted. To assess the applicability of this process for regular treatment of the waste, a feasibility study on pilot plant scale using six stage mixer settler was operated to treat the ILLW. The results indicated that almost >99.90% alpha-emitting actinides are removed. Dilute nitric acid (0.5M HNO3) served as the most efficient strippant for all these actinides. This facilitate an easy regeneration of the extractant which can be recycled. This method is useful in obtaining alpha-free wastes and had positive impact on ease and safety aspects during subsequent waste treatment and long term storage. 相似文献
48.
A. B. Deshpande S. M. Kale S. L. Kapur 《Journal of polymer science. Part A, Polymer chemistry》1973,11(9):2105-2109
Styrene is polymerized with chromium acetylacetonate–triisobutylaluminum catalyst at 40°C in a benzene medium. At the stoichiometric ratio of Al/Cr of 4, the activity for polymerization was found to be maximum. Further, the kinetic studies were carried out at this ratio of Al/Cr of maximum activity. The kinetics of polymerization and the total activation energy around 10.00 kcal/mole suggest a coordinate anionic mechanism. 相似文献
49.
We describe protocols for the fabrication of microfluidic devices in plastics using a number of different embossing masters. Masters were fabricated by deep reactive ion etching (DRIE) of silicon (100), wet etching of silicon (100) and (110), and SU-8 processing. Structures embossed into a cyclo-olefin polymer were characterized in terms of the quality of pattern transfer as well as of the surface roughness. High quality pattern transfer was achieved with masters containing structures with angled sidewalls. Pattern distortions occurring during de-embossing were minimized by using masters consisting of SU-8 (which has a thermal expansion coefficient close to that of the substrates). Structures embossed with SU-8 masters also exhibited the lowest surface roughness. However, due to structural deformation, the reusability of the masters prepared for this study extended to only five embossing experiments. Masters fabricated on silicon, on the other hand, were more robust, but were subject to breakage during the de-embossing phase of the experiment. The results of this study will guide researchers in choosing master fabrication methods that will provide profile and surface characteristics of embossed microfluidic channels that are advantageous to their specific application. 相似文献
50.
R Gupta A Kapur J L Beck M M Sheil 《Rapid communications in mass spectrometry : RCM》2001,15(24):2472-2480
Positive ion electrospray ionization mass spectra of 16 base-pair double-stranded (ds)DNA have been obtained with essentially no ions from single-stranded DNA present. Single-stranded DNA was minimized by: (1) careful choice of DNA sequences; (2) the use of a relatively high salt concentration (0.1 M ammonium acetate, pH 8.5), and, (3) a low desolvation temperature (40 degrees C). Similarly, ESI-MS complexes of dsDNA with cisplatin, daunomycin and distamycin were obtained that contained only negligible amounts of single-stranded DNA. The complexes with daunomycin and distamycin were more stable to strand separation in the gas phase than dsDNA alone. This is in agreement with solution studies and with other recent gas phase results. These data contrast with many earlier ESI-MS studies of dsDNA and DNA/drug complexes in which ions from ssDNA are also normally observed. 相似文献