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81.
Bijay K. Mishra Partha Mukherjee Sukalyan Dash Sabita Patel Hari N. Pati 《合成通讯》2013,43(14):2529-2539
Some monomeric and dimeric surfactants with functional head groups have been synthesized from di- and triethanolamine synthons. The treatment of alkyl bromide with triethanolamine resulted in simultaneous N-alkylation and O-alkylation products. However, with diethanolamine, N-alkylated products were obtained, which were further used to synthesize various double-tailed surfactants and gemini surfactants. 相似文献
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83.
Indrajyoti Mukherjee Dipankar Haldar Soumen Ghosh 《Journal of Dispersion Science and Technology》2013,34(10):1430-1441
APSA-80, an useful pesticide spray adjuvant is a mixture of 2-[2-(4-nonylphenoxy) ethoxy] ethanol, 1-butanol and tall oil fatty acids. It is strongly surface active and can decrease the surface tension of water to ~20 mNm?1 at its critical micelle concentration (CMC) of 0.006 g%. APSA-80 itself and its binary mixtures, (APSA-80 + water) and (APSA-80 + isopropylmyristate [IPM]) and ternary mixtures (APSA-80 + water +IPM) can undergo a number of physical changes with rise in temperature; the main changes are in color, turbidity and phases. The ternary mixtures of APSA-80/water/IPM with changing compositions can form mono-, bi-, and triphasic solutions as well as gels and viscous solutions. The gel and viscous phases show characteristic rheological properties of both shear thinning and thickening types. They also show permeation of hydrophilic and oleophilic dyes through them. SEM and optical microscopic measurements have shown interesting surface morphologies of the gels and their vertical projections in three-dimensional pictorial mode. Salts like LiCl, NaCl, KCl, CsCl, MgSO4, and Al2(SO4)3 can have both minor and major effects on the gel consistencies. The alkanols like ethanol, propanol, and isopropanol are also mild to fairly large gel influencing co solvents. The antibacterial properties of APSA-80 have been studied with two Gram positive bacteria and a yeast; the activities found were moderate. 相似文献
84.
The temperature‐ and electric field‐dependent dielectric relaxation and polarisation of a new chiral swallow tailed antiferroelectric liquid crystal, i.e. 1‐ethylpropyl (S)‐2‐{6‐[4‐(4′‐decyloxyphenyl)benzoyloxy]‐2‐naphthyl}propionate (abbreviated as EP10PBNP), were investigated. The electric field‐induced dielectric loss spectra of EP10PBNP revealed electroclinic and anomalous dielectric behaviour in the chiral smectic A (SmA*)–chiral antiferroelectric smectic C (SmCA*) pre‐transitional regime. From an analysis of thermal hysteresis of the dielectric constant, electric field‐induced polarisation and dielectric loss spectra, the appearance of a ferrielectric‐like mesophase is observed followed by an unstable SmCA* phase in the SmA*–SmCA* pre‐transitional regime. 相似文献
85.
Chinmoy Mukherjee 《Journal of carbohydrate chemistry》2013,32(4):213-221
A general, odorless, one‐pot methodology has been developed for the preparation of 1,2‐trans‐thioglycosides and thio‐Michael addition products of carbohydrate derivatives through triphenyl phosphine‐mediated cleavage of disulfides and reaction of the thiolate formed in situ with glycosyl bromides and glycosyl conjugated alkenes. 相似文献
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87.
Dr. Chinmoy Mukherjee Kaarina Mäkinen Prof. Dr. Johannes Savolainen Prof. Dr. Reko Leino 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(24):7961-7974
A series of oligovalent carbohydrate assemblies (ranging from mono‐ to pentavalent), derived from three structurally different β‐linked or β‐(1→2)‐linked mannosides, has been chemically synthesized, and the respective compounds have been biologically evaluated in order to investigate their immunostimulatory properties. The Crich methodology for β‐mannosylation was successfully utilized to introduce the β‐linkages, and a click chemistry protocol was utilized to generate the oligovalent derivatives. A convenient protecting group strategy involving the simultaneous use of both p‐methoxybenzyl and benzylidene groups was employed, which allowed a simple and cost‐effective global deprotection step. The immunomodulatory properties of the synthesized multivalent mannosides were evaluated by assessing cytokine production in human white blood cell cultures. The Th2‐type cytokines interleukin‐4 and interleukin‐5 (IL‐4 and IL‐5), the Th1 cytokine interferon‐γ (IFN‐γ), the Treg cytokine IL‐10, and the pro‐inflammatory cytokine tumor necrosis factor (TNF) were included in the screening. A single trivalent acetylated mannobiose derivative was identified as a potent inducer of Treg and Th1 immune response, resulting in strong IL‐10 and moderate IFN‐γ productions dose‐dependently, while inducing no Th2 cytokine response. The immunomodulatory properties of this trivalent mannoside were further studied in vitro in allergen (Bet v)‐stimulated human peripheral blood mononuclear cell cultures of birch pollen allergic subjects. Stimulation with birch pollen induced strong IL‐4 and IL‐5 responses, which could be suppressed by the trivalent acetylated mannobiose derivative. The IL‐10 response was also suppressed, whereas the production of IFN‐γ was strongly enhanced. The results suggest that the identified lead compound has suppressive effects on the Th2‐type allergic inflammatory response and shows potential as a possible lead adjuvant for the specific immunotherapy of allergies. 相似文献
88.
Modification of Extended Open Frameworks with Fluorescent Tags for Sensing Explosives: Competition between Size Selectivity and Electron Deficiency
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Bappaditya Gole Dr. Arun Kumar Bar Prof. Partha Sarathi Mukherjee 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(8):2276-2291
Three new electron‐rich metal–organic frameworks ( MOF‐1 – MOF‐3 ) have been synthesized by employing ligands bearing aromatic tags. The key role of the chosen aromatic tags is to enhance the π‐electron density of the luminescent MOFs. Single‐crystal X‐ray structures have revealed that these MOFs form three‐dimensional porous networks with the aromatic tags projecting inwardly into the pores. These highly luminescent electron‐rich MOFs have been successfully utilized for the detection of explosive nitroaromatic compounds (NACs) on the basis of fluorescence quenching. Although all of the prepared MOFs can serve as sensors for NACs, MOF‐1 and MOF‐2 exhibit superior sensitivity towards 4‐nitrotoluene (4‐NT) and 2,4‐dinitrotoluene (DNT) compared to 2,4,6‐trinitrotoluene (TNT) and 1,3,5‐trinitrobenzene (TNB). MOF‐3 , on the other hand, shows an order of sensitivity in accordance with the electron deficiencies of the substrates. To understand such anomalous behavior, we have thoroughly analyzed both the steady‐state and time‐resolved fluorescence quenching associated with these interactions. Determination of static Stern–Volmer constants (KS) as well as collisional constants (KC) has revealed that MOF‐1 and MOF‐2 have higher KS values with 4‐NT than with TNT, whereas for MOF‐3 the reverse order is observed. This apparently anomalous phenomenon was well corroborated by theoretical calculations. Moreover, recyclability and sensitivity studies have revealed that these MOFs can be reused several times and that their sensitivities towards TNT solution are at the parts per billion (ppb) level. 相似文献
89.
Insights into the AIEE of 1,8‐Naphthalimides (NPIs): Inverse Effects of Intermolecular Interactions in Solution and Aggregates
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Sanjoy Mukherjee Prof. Dr. Pakkirisamy Thilagar 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(26):8012-8023
Systematic structural perturbation has been used to fine‐tune and understand the luminescence properties of three new 1,8‐naphthalimides (NPIs) in solution and aggregates. The NPIs show blue emission in the solution state and their fluorescence quantum yields are dependent upon their molecular rigidity. In concentrated solutions of the NPIs, intermolecular interactions were found to quench the fluorescence due to the formation of excimers. In contrast, upon aggregation (in THF / H2O mixtures), the NPIs show aggregation‐induced emission enhancement (AIEE). The NPIs also show moderately high solid‐state emission quantum yields (ca. 10–12.7 %). The AIEE behaviour of the NPIs depends on their molecular rigidity and the nature of their intermolecular interactions. The NPIs 1 – 3 show different extents of intermolecular (π–π and C?H???O) interactions in their solid‐state crystal structures depending on their substituents. Detailed photophysical, computational and structural investigations suggest that an optimal balance of structural flexibility and intermolecular communication is necessary for achieving AIEE characteristics in these NPIs. 相似文献
90.
Sanjoy Mukherjee Prof. Dr. Pakkirisamy Thilagar 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(29):9052-9062
Three new NPI–BODIPY dyads 1 – 3 (NPI=1,8‐naphthalimide, BODIPY=boron‐dipyrromethene) were synthesized, characterized, and studied. The NPI and BODIPY moieties in these dyads are electronically separated by oxoaryl bridges, and the compounds only differ structurally with respect to methyl substituents on the BODIPY fluorophore. The NPI and BODIPY moieties retain their optical features in molecular dyads 1 – 3 . Dyads 1–3 show dual emission in solution originating from the two separate fluorescent units. The variations of the dual emission in these compounds are controlled by the structural flexibilities of the systems. Dyads 1 – 3 , depending on their molecular flexibilities, show considerably different spectral shapes and dissimilar intensity ratios of the two emission bands. The dyads also show significant aggregation‐induced emission switching (AIES) on formation of nano‐aggregates in THF/H2O with changes in emission color from green to red. Whereas the flexible and aggregation‐prone compound 1 shows AIES, rigid systems with less favorable intermolecular interactions (i.e., 2 and 3 ) show aggregation‐induced quenching of emission. Correlations of the emission intensity and structural flexibility were found to be reversed in solution and aggregated states. Photophysical and structural investigations suggested that intermolecular interactions (e.g., π–π stacking) play a major role in controlling the emission of these compounds in the aggregated state. 相似文献