Copper‐Catalyzed Synthesis of Pentasubstituted Pyridines from N‐Sulfonyl Ketenimines, 1,1,3,3‐Tetramethylguanidine,and Acetylene Dicarboxylates

Regioselective synthesis of pentasubstituted pyridines has been developed in moderate‐to‐good yields by the reaction of sulfonyl azides, alkynes, and a dialkyl acetylenedicarboxylate? tetramethylguanidine adduct catalyzed by CuI in MeCN at room temperature.     

Mechanistic Study of Ozone-Water Reaction and Their Reaction Products with Gas Phase Elemental Mercury:A Computational Study

The interaction of oxygen of water and central oxygen of ozone produces stable H₂O‐O₃ complex with no barrier. With decomposition of this complex through H‐abstraction by O₃ and O‐abstraction by H₂O, four possible product channels have been found. The reaction of mercury and the products of water‐ozone reaction have been studied. All geometrical and AIM parameters of intermediate, transition states, and the products of reactions are calculated and thermodynamic parameters are obtained. The negative value of free energy show that channels Hg+H₂OO, Hg+H₂O₂ and Hg+H₂O₄ in hydrogen tetroxide form (HTO) may be the main reaction channels.     

Synthesis of Functionalized Tetrahydro‐4‐oxoindeno[1,2‐b]pyrroles from Ninhydrin,Acetylenedicarboxylates, and Primary Amines

A one‐pot synthesis of dialkyl 1,3a,4,8b‐tetrahydro‐3a,8b‐dihydroxy‐1‐alkyl‐4‐oxoindeno[1,2‐b]pyrrole‐2,3‐dicarboxylates via three‐component reaction from indan‐1,2,3‐trione hydrate (ninhydrin), primary amines, and dialkyl acetylenedicarboxylates is described.     

Novel One‐Pot Synthesis of Functionalized Quinolines from Isocyanides,Aniline, and Acetylene Dicarboxylate via Cu‐Catalyzed Intramolecular C─H Activation Reactions

The one‐pot synthesis of a novel class of substituted quinoline derivatives with good yields is achieved via the Cu‐catalyzed intramolecular C─H activation reaction between isocyanides, aniline, and acetylene dicarboxylate in MeCN at room temperature. The existence of one‐pot conditions, availability of a starting material‐catalyst, the absence of column chromatography, and a high yield of products are among the advantages of this method. The structures are confirmed spectroscopically (¹H NMR and ¹³C NMR, IR, and EI‐MS) and through elemental analyses.     

Copper‐Catalyzed One‐Pot Synthesis of Functionalized Pyrroles from Sulfonyl Azides,Alkynes, and (p‐Toluenesulfonyl)methyl Isocyanide

Ketenimine intermediates generated by the addition of copper acetylides to sulfonyl azides are trapped by (p‐toluenesulfonyl)methyl isocyanide (TsCH₂NC), in the presence of Et₃N, to afford functionalized pyrroles in moderate‐to‐good yields.     

A synthesis of phosphorylated dioxohexahydropyrimidines from <Emphasis Type="Italic">N</Emphasis>,<Emphasis Type="Italic">N</Emphasis>′-dimethylurea,activated acetylenes,and trialkyl phosphites

An efficient synthesis of alkyl 5-(dialkoxy- phosphoryl)-1,3-dimethyl-2, 6-dioxo-hexahydropyrimidine-4-carboxylates is described. This involves the reaction of N,N′-dimethylurea and dialkyl acetylendicarboxylates in the presence of trialkyl phosphites. Under similar conditions, triphenyl phosphite led to alkyl 5-(diphenoxyphosphoryl)-1,3-dimethyl-2,6-dioxo-hexahydro-4-pyrimidinecarboxylates.