ContributionsGraph partitions with minimum degree constraints

Given a graph with n nodes and minimum degree δ, we give a polynomial time algorithm that constructs a partition of the nodes of the graph into two sets X and Y such that the sum of the minimum degrees in X and in Y is at least δ and the cardinalities of X and Y differ by at most δ(δ + 1 if n ≠ δ(mod 2)). The existence of such a partition was shown by Sheehan (1988).     

维吾尔族长寿老人红细胞ABO血型遗传多态性分析

在维吾尔族长寿老人最稠密的和田地区，调查了维吾尔族长寿老人红细胞ABO血型遗传多态性，对维吾尔老人红细胞ABO血型、基因频率分布情况进行研究，被调查的200例长寿老人中，B血型中占39％、AB血型占28％、A血型占24％、O血型占9％，有以下特征：表征分布为B＞AB＞A＞O，基因频率Y＝0．2793，P＝0．3022，q＝0．2012；DP为0．8077，文中对红细胞ABO血型在不同非长寿人群中的分布进行了比较分析，这对于长寿的机理、生化、人类分子遗传学及临床分子医学研究具有重要意义。     

规则和统计相结合的非汉语母语者声调分析*

汉语普通话教学已经在我国各少数民族地区的教育工作中占据越来越重要的地位,然而从这些地区的相关教育实践来看,汉语普通话正面临着语音素质和教学质量较低的严峻问题。该文采用实验语音学,对比分析、偏误分析的理论及方法,考察并分析了维吾尔族学生习得汉语单字调声调的情况。主要是对初级、中级和高级阶段的50名维吾尔族学生声调的五度值曲线和声调之间相似度与标准普通话者进行对比并分析,得出维吾尔族学生对汉语声调的偏误情况以及MHK成绩的关系。通过实验结果可以发现,三组的维吾尔人学习普通话的声调都有困难。两种语言的音系、语调和重音等特性影响了第二语言中的声调特性。这种声调系统的差异导致了维吾尔族人学习普通话声调产出的困难。通过这项实验揭示了目前维吾尔学生对汉语普通话中声调发音的掌握情况,同时有助于进一步了解维吾尔族普通话学习者汉语声调的偏误。     

光纤化学传感同步吸收-荧光法的建立

建立一种光纤化学传感同步测定吸收光谱和荧光光谱的新方法。自制同步吸收-荧光比色皿,结合光纤化学传感技术,建立同步吸收-荧光光谱法检测仪器,分别测定罗丹明B,维生素B₂,维生素B₆等溶液的同步吸收-荧光光谱,且与传统的紫外-可见吸光光度法和荧光法进行对比。同步吸收-荧光光谱法测得罗丹明B,维生素B₂,维生素B₆与传统吸光光度法和荧光光谱法检测的吸收光谱图和荧光光谱的图谱大体一致。最大荧光强度波长与传统的荧光方法比较准确度高,但最大吸收波长略有偏差。同步吸收-荧光光谱法等同于同步测定荧光物质的吸收光谱和荧光光谱,实现二光谱合二为一,测定最大发射波长时准确度高,但最大吸收波长略有偏差,值得深一步研究。     

基于mcnp5程序研究60Co γ射线的剂量增强效应

用蒙特卡罗方法研究了金和硅交界时60Coγ射线入射产生的剂量梯度分布,并且通过mcnp5程序建立了一个三维的金硅界面结构模型,进而计算了剂量增强因子.计算结果表明:界面附近硅一侧具有明显的剂量梯度分布,界面剂量增强因子为1.76.     

Photon and positron generation by ultrahigh intensity laser interaction with electron beams

This study investigates the generation of high energy photons and positrons using focused ultrahigh intensity femtosecond laser pulses on a relativistic electron beam with a set of two-dimensional particle-in-cell simulations. We consider circularly and linearly polarized, single and spatially separated double laser pulses. We model both 500 MeV and 1 GeV electron beams. Higher positron production is obtained using circularly polarized laser pulses. Using double pulses, the focusing effect of the ponderomotive force confines the electrons to a small volume, generating additional energetic photons and positrons. The positron spectral distributions are effectively modified by these variations. When the electron beam energy is doubled, the number of positrons increased, while the cutoff energy remained nearly constant.     

From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking

Small-molecule stabilization of protein-protein interactions (PPIs) is a promising strategy in chemical biology and drug discovery. However, the systematic discovery of PPI stabilizers remains a largely unmet challenge. Herein we report a fragment-linking approach targeting the interface of 14-3-3 and a peptide derived from the estrogen receptor alpha (ERα) protein. Two classes of fragments—a covalent and a noncovalent fragment—were co-crystallized and subsequently linked, resulting in a noncovalent hybrid molecule in which the original fragment interactions were largely conserved. Supported by 20 crystal structures, this initial hybrid molecule was further optimized, resulting in selective, 25-fold stabilization of the 14-3-3/ERα interaction. The high-resolution structures of both the single fragments, their co-crystal structures and those of the linked fragments document a feasible strategy to develop orthosteric PPI stabilizers by linking to an initial tethered fragment.     

新型二氧代氮杂茂并[3′,4′-d]异噁唑衍生物的合成

在三乙胺作用下,N-取代苯基马来酰亚胺与α-氯代对甲氧基苯甲醛肟发生1,3-偶极环加成反应,合成了6个新型3-(对甲氧基苯基)-5-芳基-3a,6a-二氢-4,6-二氧代氮杂茂并[3′,4′-d]异噁唑衍生物,其结构经1HNMR,IR和元素分析确证。     

新型二氧代氮杂茂并[3'''',4''''-d]异噁唑衍生物的合成

在三乙胺作用下,N-取代苯基马来酰亚胺与α-氯代对甲氧基苯甲醛肟发生1,3-偶极环加成反应,合成了6个新型3-(对甲氧基苯基)-5-芳基-3a,6a-二氢-4,6-二氧代氮杂茂并[3',4'-d]异噁唑衍生物,其结构经1H NMR, IR和元素分析确证.