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81.
Anjali Dhingani Jaydeep Patel Kevin Garala Mihir Raval Abhay Dharamsi 《Journal of Dispersion Science and Technology》2014,35(5):619-640
The objective of the present investigation was to develop microemulsion-based transdermal systems of highly water soluble drug, Atenolol, by quality by design technique. Atenolol-loaded W/O microemulsions were optimized using D-optimal design with concentrations of oil, surfactants mixture, and water as independent variables, which was converted into microemulsion-based gel (MBG). The results of in vitro permeation of the optimized batch of Atenolol-loaded MBG revealed significant increase in permeability parameters as compared to its convention gel. All results suggested suitability of W/O type MEs as carriers for transdermal delivery of highly water soluble drug, Atenolol. 相似文献
82.
83.
Herein, we report a facile method for synthesizing MoCo-layered double hydroxide (LDH) nanosheets employing Prussian blue analog (PBA) as the precursor. The introduction of Mo in Co-LDH modulates the electronic structure, increases the number of active sites and electrochemical surface area to improve the hydrogen evolution, oxygen evolution, and overall water splitting activity. As a result, PBA-derived Mo0.25Co0.75-LDH nanosheets demonstrated 10 mA cm?2 current density at only 220 mV and 115 mV overpotentials for OER and HER, respectively. The overall water splitting was attained at 1.52 V cell voltage for 10 mA cm?2 current density. 相似文献
84.
85.
Dattatraya N. Bhangare Rohit G. Shinde Pushpalata D. Pawar Milind D. Nikalje Mahendra N. Lokhande 《Journal of heterocyclic chemistry》2021,58(9):1878-1882
This method involves the direct asymmetric aldol reaction of (−)-menthyl isothiocyanatoacetate 5 with a variety of substituted aromatic aldehydes, which offers a convenient method for the synthesis of intermediate containing biologically relevant α-amino β-hydroxyl groups in oxazolidine ring. In this methodology, the products show remarkable diastereoselectivity using Sc(OTf)3 as a catalyst and easily accessible (−)-menthol as a chiral auxiliary. This approach includes some important aspects such as mild reaction conditions, high yields, and excellent diastereoselectivity with a number of substituted aromatic aldehydes. The optimization and effect of different catalysts were studied at different reaction conditions and it is found that Sc(OTf)3 shows excellent diastereoselectivity at −45°C. 相似文献
86.
Patel Urvi Girme Aboli Patel Kalpana Ghule Chetana Hingorani Lal Gandhi Tejal 《平面色谱法杂志一现代薄层色谱法》2021,34(3):217-228
JPC – Journal of Planar Chromatography – Modern TLC - The objective of the present work was to develop a simple, specific, and fast high-performance thin-layer chromatographic (HPTLC)... 相似文献
87.
James P. Phelan Evan J. Patel Prof. Dr. Jonathan A. Ellman 《Angewandte Chemie (International ed. in English)》2014,53(42):11329-11332
The first example of a catalytic enantioselective addition to and nitronate protonation of trisubstituted nitroalkenes to produce highly enantioenriched products with a tetrasubstituted carbon is reported. Thioacids added in excellent yields and with high enantioselectivities to both activated and unactivated nitroalkenes. The 1,2‐nitrothioacetate products can be readily converted in two steps to biomedically relevant 1,2‐aminosulfonic acids without loss of enantiopurity. 相似文献
88.
Prof. Ashok R. Patel Nick Cludts Mohd Dona Bin Sintang Benny Lewille Ans Lesaffer Prof. Koen Dewettinck 《Chemphyschem》2014,15(16):3435-3439
The preparation and characterization of oleogels structured by using a combination of a surface‐active and a non‐surface‐active polysaccharide through an emulsion‐templated approach is reported. Specifically, the oleogels were prepared by first formulating a concentrated oil‐in‐water emulsion, stabilized with a combination of cellulose derivatives and xanthan gum, followed by the selective evaporation of the continuous water phase to drive the network formation, resulting in an oleogel with a unique microstructure and interesting rheological properties, including a high gel strength, G′>4000 Pa, shear sensitivity, good thixotropic recovery, and good thermostability. 相似文献
89.
Amit K. Gupta Harish Manoj K. Rai Mahendra Phulwaria Tanvi Agarwal N. S. Shekhawat 《Applied biochemistry and biotechnology》2014,173(6):1481-1494
The present study described an improved and reproducible in vitro regeneration system for Terminalia arjuna using nodal segment explants obtained from a mature plant. Shoot tips excised from in vitro proliferated shoots were encapsulated in 3 % sodium alginate and 100 mM CaCl2?2H2O for the development of synthetic seeds which may be applicable in short-term storage and germplasm exchange of elite genotype. Shoot multiplication was significantly influenced by a number of factors, namely types and concentrations of plant growth regulators, medium composition, repeated transfer of mother explants, subculturing of in vitro regenerated shoot clumps, agar concentrations, and temperature. Maximum numbers of shoots (16.50?±?3.67) were observed on modified Murashige and Skoog (MMS) medium containing 0.5 mg l?1 of benzylaminopurine (BAP) and 0.1 mg l?1 of naphthalene acetic acid (NAA). To shortening the regeneration pathway, rooting of micropropagated shoots under in vitro condition was excluded and an experiment on ex vitro rooting was conducted and it was observed that the highest percentage of shoots rooted ex vitro when treated with indole-3-butyric acid (IBA, 250 mg l?1)?+?2-naphthoxy acetic acid (NOA, 250 mg l?1) for 5 min. The well-developed ex vitro rooted shoots were acclimatized successfully in soilrite under greenhouse conditions with 80 % survival of plants. Randomly amplified polymorphic DNA (RAPD) analysis confirmed that all the regenerated plants were genetically identical to the mother plant, suggesting the absence of detectable genetic variation in the regenerated plantlets. To the best of our knowledge, this is the first report on synthetic seed production as well as ex vitro rooting and genetic fidelity assessment of micropropagated shoots of T. arjuna. 相似文献
90.
Mohan N. Patel Chintan R. Patel Hardik N. Joshi Pankaj A. Vekariya 《Applied biochemistry and biotechnology》2014,172(4):1846-1858
The platinum(II) complexes with N,S-donor ligand have been synthesised and characterised by physiological techniques like elemental, electronic, Fourier transform infrared, hydrogen-1 nuclear magnetic resonance (1H NMR) and liquid chromatography–mass spectrometry spectra. The synthesised complexes have been checked for their DNA binding ability by absorption titration and viscosity measurement, and the results show that the complexes binds to herring sperm DNA (HS DNA) via covalent mode of binding. The DNA cleavage activity of synthesised complexes has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA, showing the unwinding of the negatively charged supercoiled DNA. Brine shrimp (Artemia cysts) lethality bioassay technique has been applied for the determination of toxic property of synthesised complexes in terms of micromolars. 相似文献