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91.
Silvio Aime Alessandro Barge Mauro Botta Alvaro S. De Sousa David Parker 《Angewandte Chemie (International ed. in English)》1998,37(19):2673-2675
A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium(III ) complex with an octadentate, neutral macrocyclic ligand (kex( M )<kex( m )). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging. 相似文献
92.
Arjun Kumbhar Santosh Kamble Madhuri Barge Gajanan Rashinkar Rajashri Salunkhe 《Tetrahedron letters》2012,53(22):2756-2760
A new Brönsted acid hydrotrope combined catalyst (BAHC) has been developed and applied in acid catalyzed synthesis of pyrido[2,3-b]pyrazines and quinoxalines in an aqueous medium at ambient temperature with excellent yields. Interestingly, the catalyst can be easily recovered after the reactions and reused. Furthermore, BAHC catalyst worked well and avoids the use of organic solvents. We have reported herein the synthetic pathway which has less disastrous effect in the atmosphere and human survival. 相似文献
93.
A. Madhuri B. Nagaraju N. Harikrishna Gopal Reddy 《Applied biochemistry and biotechnology》2012,167(5):1199-1207
Castor (Ricinus communis L.) is an important oil seed crop having its main cultivated area in India, China, and Brazil in dry land farming. Castor husk is generated as waste in castor oil production. Use of castor husk waste as substrate is studied for alkaline protease production by Bacillus altitudinis GVC11 in solid-state fermentation. Various parameters like moisture content, incubation period, particle size, effect of carbon and nitrogen sources are studied and optimized for enzyme production. Highest enzyme production of 419,293 units per gram husk is obtained. Cost of enzyme production can be reduced by using castor husk as substrate. 相似文献
94.
Bhim Bali Prasad Mahavir Prasad TiwariRashmi Madhuri Piyush Sindhu Sharma 《Journal of chromatography. A》2010,1217(26):4255-4266
Thyroxine is a known disease biomarker which demands a highly sensitive and selective technique to measure ultratrace level with enantiodifferentiation of its optical isomers (d- and l-), in real samples. In this work, an approach of hyphenation between molecularly imprinted micro-solid phase extraction and a complementary molecularly imprinted polymer-sensor was adopted for enantioseparation, preconcentration, and analysis of d- and l-thyroxine. In both techniques, the same imprinted polymer, coated on a vinyl functionalized self-assembled monolayer modified silver wire, was used as the respective extraction fiber as well as sensor material. This combination enabled enhanced preconcentration of test analyte substantially so as to achieve the stringent limit [limit of detection: 0.0084 ng mL−1, RSD = 0.81%, S/N = 3 (d-thyroxine); 0.0087 ng mL−1, RSD = 0.63%, S/N = 3 (l-thyroxine)] of clinical detection of thyroid-related diseases, without any problems of non-specific false-positive contribution and cross-reactivity. 相似文献
95.
A commercial epoxy diglycidylether of bisphenol-A (DGEBA) was modified by adding fluorinated poly(aryl ether ketone) fluoropolymer and in turn metal micro powders (Ni, Al, Zn, and Ag) and coated on mild steel. Two curing agents were used; triethylenetetramine (a low temperature curing agent) and hexamethylenediamine (a high temperature curing agent) for understanding the curing temperature effect on the properties. Variations in tribological properties (dynamic friction and wear) and surface energies with varying amounts of metal powders and curing agents were evaluated. When cured at 30 °C, dynamic friction and wear decrease significantly due to phase separation reaction being favored between the fluoropolymer and the epoxy. However, when cured at 80 °C, friction and wear increase; this can be explained in terms of a crosslinking reaction favored at that temperature. There is a significant decrease in surface energies with the addition of modifiers. 相似文献
96.
Lorenzo Tei Dr. Alessandro Barge Dr. Simonetta Geninatti Crich Dr. Roberto Pagliarin Dr. Viviana Negri Dr. Daniela Ramella Dr. Giancarlo Cravotto Prof. Silvio Aime Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(27):8080-8087
To design efficient targeting strategies in magnetic resonance (MR) molecular imaging applications, the formation of supramolecular adducts between (strept)avidin ((S)Av) and tribiotinylated Gd‐DOTA‐monoamide complexes (DOTA=1,4,7,10‐tetraazacyclododecane‐N,N′,N′′,N′′′‐tetraacetic acid) was explored. Two compounds based on the trivalent core of tris(2‐aminoethyl)amine each containing three biotin molecules and one ( L1 ) or three ( L2 ) DOTA‐monoamide (DOTAMA) ligands were synthesized. In these tribiotinylated derivatives the biotins are spaced far enough apart to allow the formation of the supramolecular adduct with the protein and to host the chelating units in between the (S)Av layers. Size exclusion HPLC analyses indicated complete formation of very high molecular weight polymers (>2 MDa) with (S)Av in solution. A 1H NMR spectroscopy relaxometric study on the obtained polymeric adducts showed a marked increase of the relaxivity at 35–40 MHz as a consequence of the lengthening of the tumbling time due to the formation of Gd‐chelates/(S)Av polymers. The most efficient Gd3 L2 /(S)Av polymeric system was used for a test in cell cultures. The target is represented by a neural cell adhesion molecule (NCAM), which is overexpressed in Kaposi’s sarcoma cells and tumor endothelial cells (TEC) and that is efficiently recognized by a biotinylated tetrameric peptide (C3d‐Bio). In vitro experiments showed that only cells incubated with both C3d‐Bio and Gd3 L2 /SAv polymer were hyperintense with respect to the control. Relaxation rates of cell pellets incubated with Gd3 L2 /SAv alone were not significantly different from the untreated cells demonstrating the absence of a specific binding. 相似文献
97.
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99.
Madhuri Grover Tapan Behl Tarun Virmani Mohit Sanduja Hafiz A. Makeen Mohammed Albratty Hassan A. Alhazmi Abdulkarim M. Meraya Simona Gabriela Bungau 《Molecules (Basel, Switzerland)》2022,27(18)
Since ancient times, Chrysopogon zizanioides has been utilized as a traditional medicinal plant for the treatment of numerous ailments, but neither its plant extract form nor its phytoconstituents have been fully explored. With this in mind, the present research was designed to isolate and structurally characterize one of its chemical constituents and evaluate its cytotoxic potential. Therefore, an ethanolic extract of roots was prepared and subjected to column chromatography using solvents of varying polarities. The obtained pure compound was characterized using various chromatographic and spectroscopic techniques such as high-performance liquid chromatography (HPLC), carbon and proton nuclear magnetic resonance (NMR), and liquid chromatography–mass spectroscopy (LC-MS) and identified as longifolene. This compound was evaluated for its cytotoxic potential using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on the prostate (DU-145), oral (SCC-29B) cancer cell line and normal kidney cell line (Vero cells), taking doxorubicin as a standard drug. The obtained outcomes revealed that longifolene possesses cytotoxic potential against both prostate (IC50 = 78.64 µg/mL) as well as oral (IC50 = 88.92 µg/mL) cancer cell lines with the least toxicity in healthy Vero cells (IC50 = 246.3 µg/mL) when compared to doxorubicin. Hence, this primary exploratory study of longifolene exhibited its cytotoxic potency along with wide safety margins in healthy cell lines, giving an idea that the compounds possess some ability to differentiate between cancerous cells and healthy cells. 相似文献
100.
Madhuri A. Phadke Sudhir S. Kulkarni Sandeep K. Karode Deepak A. Musale 《Journal of Polymer Science.Polymer Physics》2005,43(15):2074-2085
The rheology and phase‐boundary characteristics of various solutions comprising three polyacrylonitrile (PAN) grades dissolved in solutions of N,N‐dimethylformamide + salt (LiCl, ZnCl2, or AlCl3) additives were correlated with the resulting membrane morphology as determined by microscopy and permeability measurements. The phase separation characteristics of the dope solution were not markedly affected by the PAN molecular weight (MW); however, they were affected by the salt additive. For higher MW grades, the effect of salt addition can also be masked by the increased self‐association tendency of the polymer chains. PAN‐B and ‐C membranes were clearly less asymmetric in structure than the lower MW PAN‐A–based membranes. This is attributed to the higher viscosity/lower diffusivity of the PAN‐B and ‐C solutions, which results in slower solvent–nonsolvent exchange during the phase inversion process. Two factors reduce the incidence of surface defects (increased bubble points): (a) higher solution viscosity dampens surface perturbations during phase inversion, and (b) phase inversion pathways resulting in more homogenous morphology lead to membranes with higher bubble points. © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2074–2085, 2005 相似文献