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排序方式: 共有189条查询结果,搜索用时 15 毫秒
181.
Pedro P. Madeira Jos A. Teixeira Eugnia A. Macedo Larissa M. Mikheeva Boris Y. Zaslavsky 《Fluid Phase Equilibria》2008,267(2):150-157
Distribution coefficients for a variety of proteins and certain other biomolecules (peptides, amino acids, and carbohydrates) (overall 27 different solutes) were measured in aqueous two-phase systems (ATPSs) dextran (Dex)–polyethylene glycol (PEG) and Dex–Ucon 50-HB-5100 (Ucon—a random copolymer of ethylene glycol and propylene glycol) both containing 0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4, at 23 °C. Distribution coefficients of some selected solutes were also measured in the above two-phase systems at three different polymer concentrations for each system. It was established that the distribution coefficients for all the proteins examined in the ATPSs are correlated according to the so-called Collander linear equation. 相似文献
182.
Dalmora SL Sangoi Mda S da Silva LM Macedo RO Barth T 《Journal of separation science》2008,31(1):169-176
A CZE method was developed and validated for the analysis of etoricoxib in pharmaceutical dosage forms, using prilocaine as an internal standard. The CZE method was carried out on a fused-silica capillary (50 microm id, effective length 40 cm). The BGE consisted of 25 mM tris-phosphate solution at pH 2.5. The capillary temperature was maintained at 35 degrees C, the applied voltage was 25 kV, the injection was performed using the pressure mode at 50 mbar for 5 s, with detection at 234 nm using a photodiode array detector. The method was linear in the range of 2-150 microg/mL (r(2) = 0.9999). The specificity and stability-indicating capability were proven through the degradation studies and showing also that there was no interference of the excipients of the formulation. The accuracy was 99.49% with RSD of 0.66%. The limits of quantitation and detection were 2 and 0.58 microg/mL, respectively. Moreover, method validation demonstrated acceptable results for the precision, sensitivity, and robustness. The proposed method was successfully applied for the quantitative analysis of etoricoxib pharmaceutical formulations, and the results compared to the HPLC and LC-MS/MS methods, showing nonsignificant difference (p >0.05). 相似文献
183.
Costa EV Dutra LM Nogueira PC Moraes VR Salvador MJ Ribeiro LH Gadelha FR 《Natural product communications》2012,7(2):265-266
The essential oil from the leaves of Annona vepretorun was obtained by hydrodistillation using a Clevenger-type apparatus and analyzed by GC-MS and GC-FID. Eighteen compounds representing 98.1% of the crude essential oil were identified. The major compounds identified were bicyclogermacrene (43.7%), spathulenol (11.4%), alpha-felandrene (10.0%), alpha-pinene (7.1%), (E)-beta-ocimene (6.8%), germacrene D (5.8%), and p-cymene (4.2%). The trypanocidal activity against Trypanosoma cruzi epimastigote forms, as well as, the antimicrobial and antioxidant proprieties was investigated. The essential oil showed a potent trypanocidal activity with IC50 value of 31.9 +/-1.3 microg x mL(-1). For antimicrobial activity, the best result was observed against Candida tropicalis with a MIC value of 100 microg x mL(-1). For antioxidant capacity the essential oil showed weak activity. 相似文献
184.
D. A. Macedo M. R. Cesrio B. Cela D. M. A. Melo C. A. Paskocimas A. E. Martinelli R. M. Nascimento 《Crystal Research and Technology》2010,45(11):1166-1170
Strontium‐doped lanthanum manganite (La1‐xSrxMnO3 or LSM) is the material most widely used on solid oxide fuel cells cathode. In this work, nano‐scale La0.8Sr0.2MnO3 powders have been synthesized by polymeric precursor‐based methods using different polymerizing agents with the aim of evaluating the influence of this change in the final powder. The powders calcined at 700 °C for 2 h have been characterized by X‐ray diffraction (XRD), scanning electron microscopy (FE‐SEM) and Fourier transform infrared spectroscopy (FTIR) in order to investigate the quality of both synthesis routes. It is shown that the crystal structure and morphology of the particles are significantly dependent on the preparation conditions. Single phase and La0.8Sr0.2MnO3 nano‐crystalline particles less than 30 nm were obtained using ethylene glycol as polymerizing agent. FTIR results have been indicated that only the powder obtained using gelatin presented small traces of hydroxyl groups on its surface. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
185.
Cymbron T Anjos R Cabral R Macedo C Pereira Duarte C Mota-Vieira L 《Community genetics》2006,9(2):107-112
OBJECTIVES: This study aimed to characterize the prevalence of congenital heart disease (CHD) in children born alive in S?o Miguel island from January 1992 to December 2001. METHODS: Based on the Azorean Registry of CHD, which includes complete clinical and personal information, 189 patients were diagnosed. RESULTS: During this 10-year period, the average prevalence of CHD is 9.16 per 1,000 live births (range 4.77-12.75). The most frequent cardiac malformations found were: ventricular septal defect (38.1%), atrial septal defect (12.2%) and patent ductus arteriosus (11.6%). Until now, four familial clusters were identified, representing a total of 13 patients. CONCLUSIONS: This first epidemiological study of CHD in the Azorean population reveals evidence for familial aggregation, which is of great interest for understanding the genes involved in these complex pathologies. 相似文献
186.
Maria da Conceio Avelino Dias Bianco Debora Inacio Leite Frederico Silva Castelo Branco Nubia Boechat Elisa Uliassi Maria Laura Bolognesi Monica Macedo Bastos 《Molecules (Basel, Switzerland)》2022,27(23)
The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug). A polypharmacology approach is widely applied in the treatment of acquired immunodeficiency syndrome (AIDS), providing life-saving therapies for millions of people living with HIV. Despite the success in viral load suppression and patient survival of combined antiretroviral therapy (cART), the development of new drugs has become imperative, owing to the emergence of resistant strains and poor adherence to cART. 3′-azido-2′,3′-dideoxythymidine, also known as azidothymidine or zidovudine (AZT), is a widely applied starting scaffold in the search for new compounds, due to its good antiretroviral activity. Through the medicinal chemistry tool of molecular hybridization, AZT has been included in the structure of several compounds allowing for the development of multi-target-directed ligands (MTDLs) as antiretrovirals. This review aims to systematically explore and critically discuss AZT-based compounds as potential MTDLs for the treatment of AIDS. The review findings allowed us to conclude that: (i) AZT hybrids are still worth exploring, as they may provide highly active compounds targeting different steps of the HIV-1 replication cycle; (ii) AZT is a good starting point for the preparation of co-drugs with enhanced cell permeability. 相似文献
187.
Lidiani Figueiredo Santana Bruna Larissa Spontoni do Espirito Santo Mariana Bento Tatara Fbio Juliano Negro Júlio Croda Flvio Macedo Alves Wander Fernando de Oliveira Filiú Leandro Fontoura Cavalheiro Carlos Eduardo Domingues Nazrio Marcel Arakaki Asato Bernardo Bacelar de Faria Valter Arago do Nascimento Rita de Cssia Avellaneda Guimares Karine de Cssia Freitas Priscila Aiko Hiane 《Molecules (Basel, Switzerland)》2022,27(19)
Background: Studies indicate that different parts of Carica papaya Linn have nutritional properties that mean it can be used as an adjuvant for the treatment of various pathologies. Methods: The fatty acid composition of the oil extracted from the seeds of Carica papaya Linn was evaluated by gas chromatography, and an acute toxicity test was performed. For the experiment, Swiss mice were fed a balanced or high-fat diet and supplemented with saline, soybean oil, olive oil, or papaya seed oil. Oral glucose tolerance and insulin sensitivity tests were performed. After euthanasia, adiposity, glycemia, total cholesterol and fractions, insulin, resistin, leptin, MCP-1, TNF-α, and IL-6 and the histology of the liver, pancreas, and adipose tissue were evaluated. Results: Papaya seed oil showed predominance of monounsaturated fatty acids in its composition. No changes were observed in the acute toxicity test. Had lower food intake in grams, and caloric intake and in the area of adipocytes without minimizing weight gain or adiposity and impacting the liver or pancreas. Reductions in total and non-HDL-c, LDL-c, and VLDL-c were also observed. The treatment had a hypoglycemic and protective effect on insulin resistance. Supplementation also resulted in higher leptin and lower insulin and cytokine resistance. Conclusions: Under these experimental conditions, papaya seed oil led to higher amounts of monounsaturated fatty acids and had hypocholesterolemic, hypotriglyceridemic, and hypoglycemic effects. 相似文献
188.
M. R. Cesrio D. A. Macedo A. E. Martinelli R. M. Nascimento B. S. Barros D. M. A. Melo 《Crystal Research and Technology》2012,47(7):723-730
The development of novel and high‐performance cathodes is a critical issue to be addressed in order to reduce Solid Oxide Fuel Cells (SOFCs) operation temperature to the 600‐800 °C range or less. The performance of CeO2‐based composite cathodes is very attractive to such operational temperatures. In this work, La0.6Sr0.4Co0.2Fe0.8O3 (LSCF) and Ce0.8Sm0.2O1.9 (SDC) powders were synthesized by different synthesis methods and mechanically mixed to prepare LSCF‐SDC composite cathodes. Screen‐printed LSCF‐SDC/CGO/LSCF‐SDC symmetrical cells were sintered at 1150 °C for 4 h and characterized by electrochemical impedance spectroscopy in static air. X‐ray diffraction and scanning electron microscopy were employed to characterize the powders. Area specific resistance values of 0.72 and 2.77 Ω cm2 at 800 °C were found for composite cathodes containing SDC powder synthesized by modified Pechini and microwave‐assisted combustion methods, respectively. Furthermore, the activation energy of the composite cathode containing SDC derived from modified Pechini method is 1.18 eV, i.e., much lower than 1.73 eV, value determined for LSCF with SDC from microwave‐combustion method. 相似文献
189.
José Felipe dos Santos Jonatas de Oliveira S. Silva José Fernando Macedo José Carlos S. Júnior Wandson S. Almeida Eliana Midori Sussuchi 《Electroanalysis》2023,35(9):e202200563
Estrone (E1) is associated with various health and environmental issues, necessitating the development of analytical methods for monitoring E1 in different matrices. In this context, the present study reports the development of a graphene quantum dot-based electrode (GQD/E) to detect estrone in water and urine samples. Voltammetric measurements under optimized conditions demonstrated the feasibility of using GQD/E to detect estrone at trace levels in aqueous samples. Two linear dynamic ranges were obtained at concentrations from 0.05 to 10.00 μmol L−1, with limit of detection (LOD) and quantification (LOQ) of 28.0 and 96.0 nmol L−1, respectively. Furthermore, the LOD value obtained in this study is one of the lowest ever reported in the literature for the electrochemical determination of E1. The method response showed no significant variation in the current intensity of E1 in the presence of the 16 interferents. The recovery values obtained by using GQD/E to quantify estrone in fortified samples of seawater, tap water, wastewater and synthetic urine ranged from 95.9 to 108.1 %, indicating that the method presents highly sensitive for detecting estrone in aqueous matrices. 相似文献