Complexes of Chlorin e6 with Pluronics and Polyvinylpyrrolidone: Structure and Photodynamic Activity in Cell Culture

Polymeric carriers are extensively used in photodynamic therapy (PDT) for increase of efficacy of photosensitizers. Here, we report the influence of nine Pluronic copolymers on phototoxicity of chlorin e6 (Ce6), in particular 5‐ to 7‐fold rise in the phototoxicity caused by hydrophilic Pluronics F127, F108, F68 and F87 and practically no influence on Ce6 of more hydrophobic polymers. The revealed value of 0.2 mg mL^?1 of Pluronic F127 concentration sufficient for half‐of‐maximal increase of Ce6 photodynamic activity proved to be close to 0.16 mg mL^?1 inherent in well‐documented carrier poly(N‐vinylpyrrolidone) (PVP). The dissociation constants of Ce6 complexes with Pluronic F127 and PVP that were estimated from UV spectra were 0.252 and 0.036 mg mL^?1, respectively, indicating higher stability of Ce6 complex with PVP. According to the results of ¹H‐NMR studies of Ce6 complexes, the porphyrin interacts not only with hydrophobic regions but also with hydrophilic sides of both polymers.     

Elastic plane with a physical cut loaded by an antisymmetric system of forces

The problem of determining the stress-strain state of an elastic plane with a physical cut loaded by an antisymmetric system of forces is posed and solved under the condition that the tangential stresses are homogeneous across the thickness of the layer continuing the cut.     

The deuteron D-state probability

A method of direct determination of the deuteron D-state probability from the experiment, based on the d ↑ p → ppn reaction analyzis is suggested. Using the known results on the vector analyzing power in elastic NN-scattering, the values of the overall nucleon polarization and the deuteron vector polarization have been obtained. The probability of the deuteron D-state is estimated to be w _D = 0.078 ± 0.046.     

Development of novel formulations for photodynamic therapy on the basis of amphiphilic polymers and porphyrin photosensitizers. Porphyrin-polymer complexes in model photosensitized processes

We have studied the effect of amphiphilic polymers with different structure (polyvinylpyrrolidone, polyethyleneoxide and a triblock copolymer of ethylene- and propyleneoxide—(Pluronic F127)) on the photoactivity of a hematoporphyrin derivative (dimegin). It has been shown that such polymers can cause a considerable increase in the porphyrin photosensitizer (PPS) activity both in the process of singlet oxygen photogeneration and in the reaction of a substrate photooxidation in D2O and water. Among the studied polymers, polyvinylpyrrolidone appeared to have a most significant influence onto the photoactivity of dimegin. We attribute the observed effect of the amphiphilic polymers on the photoactivity of dimegin to the presence of polymer-porphyrin interactions resulting in the porphyrin disaggregation in aqueous phase. Using 1H NMR spectroscopy, we have found that dimegin binds to the polymers via the PPS interaction mainly with the hydrophobic fragments of polymeric macromolecules. However, in the case of polyvinylpyrrolidone we observed also PPS interactions with the hydrophilic fragments of macromolecules.     

Upgraded control system of scintillation counters at CDF II muon trigger

Scintillation counters are an important part of the muon detection system at CDF II (FNAL, United States). Permanently controlling and maintaining the high performance of these detectors are essential for obtaining high-quality experimental data. The first version of the control system of scintillation counters created in 2001 was completely upgraded by us due to increased requirements for the control systems of subsystems at CDF in connection with the growth of Tevatron luminosity, the introduction of new devices, and the experience of operation.     

Long-lived excited state of spiroanthroxazine after its matrix isolation in halogenated polyolefins by supercritical fluid impregnation

Supercritical fluid impregnation was used to perform matrix isolation of spiroanthroxazine (SAO) photochromic molecules in halogenated polymer films (polyvinylchloride and tetrafluoroethylene copolymer with vinylidene fluoride). An excited (colored) SAO form not relaxing to the ground (colorless) state was stabilized in polymers. Such a long-lived excited SAO form could exist as an isomer of the B form (B₅₃₅ with an absorption band at λ_max = 535 nm) in the fluorinated polymer matrix, for which the absorption maximum was shifted by more than 75 nm to the blue, and as the B form with a small admixture of the B₅₃₅-form (in polyvinylchloride).     

Formation of multinucleon systems and nuclei with mass numbers of 6 and 7 in <Superscript>16</Superscript>O<Emphasis Type="Italic">p</Emphasis> interactions at a momentum of 3.25 GeV/<Emphasis Type="Italic">c</Emphasis> per nucleon

The results of a comparative analysis of the multiplicities of singly and doubly charged accompanying particles in the channels involving the production of six- and seven-nucleon systems in ¹⁶Op collisions at a momentum of 3.25 GeV/c per nucleon are reported. Cross sections for the yield of multinucleon systems and mean multiplicities of accompanying particles are found. The experimental data are compared with the predictions of the cascade—fragmentation—evaporation model.     

Increase in the light collection from a scintillation strip with a hole for the WLS fiber using filling materials of various types

The light collection of extruded scintillation strip samples with the help of WLS fibers placed in a longitudinal hole inside of the plates has been measured. The holes are filled with various liquid fillers. Measurements are performed under irradiation by cosmic muons. A method for pumping a liquid filler with a viscosity of more than 10 Pa s into the strip hole with a WLS fiber inside is devised and successfully tested.     

Search for a ΔΔ(1236) component of the deuteron

The dp → nnpπ⁺, dp → ppnπ⁰ and dp → pppπ^- reactions at 3.33 GeV/c deuteron momentum on the proton target were studied in order to search for a ΔΔ configuration in the deuteron. The frequent backward emission of the (pπ⁺), (nπ^o) and (pπ^?) systems in the deuteron rest frame was observed. The origin of the effect was analysed from the point of view of a possible ΔΔ admixture in the deuteron wave function. Some other sources which may contribute to the signal are indicated.     

Comparative analysis of earthquakes data recorded by the innovative Precision Laser Inclinometer instruments and the classic Hydrostatic Level System

The Hydrostatic Level System (HLS) data and the Precision Laser Inclinometer (PLI) instruments data have been comparatively analyzed in the event of surface angular oscillations induced by earthquakes. The comparative data analysis has shown an agreement on the arrival and stop time of earthquakes. The data have been analyzed within the instruments sensitivity ranges having an overlap in frequency intervals.