Catalyzation of 1,4-additions of arylboronic acids to α,β-unsaturated substrates using nickel(I) complexes

Nickel(I) complexes were generated in situ from Ni (PPh₃)₂Cl₂ using activated iron and the complexes combined with N,N′-bis(4-fluorobenzylidene) ethane-1,2-diamine (BFBED) were then used as a catalyst for the 1,4-addition reaction of arylboronic acids to α,β-unsaturated substrates. The reaction proceeded to completion and did not require the addition of a base but the addition of potassium iodide is crucial to this cross-coupling reaction. Moreover, experimental observations suggested a possible Ni(I)–Ni(III) catalytic cycle mechanism.     

Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography–mass spectrometry for solution-based ligand screening against multiple proteins

We present herein a novel bioseparation/chemical analysis strategy for protein–ligand screening and affinity ranking in compound mixtures, designed to increase screening rates and improve sensitivity and ruggedness in performance. The strategy is carried out by combining on-line two-dimensional turbulent flow chromatography (2D-TFC) with liquid chromatography–mass spectrometry (LC–MS), and accomplished through the following steps: (1) a reversed-phase TFC stage to separate the protein/ligand complex from the unbound free molecules, (2) an on-line dissociation process to release the bound ligands from the complexes, and (3) a second mixed-mode cation-exchange/reversed-phase TFC stage to trap the bound ligands and to remove the proteins and salts, followed by LC–MS analysis for identification and determination of the binding affinities. The technique can implement an ultra-fast isolation of protein/ligand complex with the retention time of a complex peak in about 5 s, and on-line prepare the “clean” sample to be directly compatible with the LC–MS analysis. The improvement in performance of this 2D-TFC/LC–MS approach over the conventional approach has been demonstrated by determining affinity-selected ligands of the target proteins acetylcholinesterase and butyrylcholinesterase from a small library with known binding affinities and a steroidal alkaloid library composed of structurally similar compounds. Our results show that 2D-TFC/LC–MS is a generic and efficient tool for high-throughput screening of ligands with low-to-high binding affinities, and structure-activity relationship evaluation.     

Optical Measurement of φ750 mm Telescope System

为了探测更高轨道的空间目标,研制了一台通光口径为φ750 mm的望远镜.该望远镜为主焦点光学系统,由一片二次非球面反射元件和四片透射元件组成,具有大视场(4°),大相对孔径(1∶1.32)和宽光谱(500～800 nm)的特点.本文以该望远镜的研制为基础,介绍了其光学系统各个元件的单独检测和系统装调完成后的整体检测方法和过程.采用样板法对系统中的球面透射元件进行了单独检测,采用透射无像差补偿器法对二次非球面反射镜进行了单独检测,采用反射无像差补偿器法对组合起来的透射校正镜组进行了检测,并且对系统装调对准之后的光学系统进行室内平行光管和室外对星观测两种方法进行检测,测量结果均满足设计要求,其中球面透镜的面形误差小于0.1个光圈,反射元件和透射元件非球面表面的面形误差均优于λ/30(λ=632.8 nm),透射校正镜组的波像差优于λ/30(λ=632.8nm).光学系统整体检测结果表明,室内和室外检测结果一致,其像面的80％能量集中度直径在4°的全视场范围内均小于2个像元,达到了设计的成像要求.     

利用Offner光学系统进行图像恢复和光学检测

设计了一种Offner光学系统,用于基于相位差异技术的图像恢复和光学系统波像差的辅助检测。该Offner光学系统采用同轴抛物面反射镜作为Offner反射镜,以高速CCD相机和Shack—Hartmann波前探测器作为接收元件,能完好地消除复色光源在图像恢复过程中带来的色差;设计的RMS波像差小于a／50（A=632．8nm）,结构简单,容易实现。利用该系统分别以分辨率板和光纤光源为目标进行了图像恢复实验,经过恢复后的图像分辨率提高了19％。此外,利用该系统,采用相位差异算法解算了系统波像差,并与Shack—Hartmann波前探测器的测量结果进行了比较。比较显示两者的RMS波像差测量值相差5％,证明该系统同样能够进行光学波前检测。     

On Solving Three-Dimensional Electrostatic Field Distribution by Multigrid Method

A highly efficient numerical algorithm using the multigrid method (MGM) is introduced to solve a three-dimensional (3-D)field distribution. Taking advantage of the restriction and prolongation in MGM computation, a more accurate field distribution can be acquired rapidly. According to the MGM algorithm, a 3-D program is accomplished, which can solve the field distributions in electron optical systems for various electrostatic lenses. The 3-D field distribution in an electrostatic concentric spherical model is tested with the MGM algorithm and with an algorithm based on the finite difference method (FDM). Comparing these two results in terms of computational efficiency and computational accuracy, it appears that MGM is superior to FDM, which is now used the most in field computations. This paper shows that the 3-D field computation using MGM greatly improves the computational efficiency of field distributions in electron optical systems and shortens the computational time.     

AgGaS_2晶体Ⅱ类非共线相位匹配CO_2激光参量上转换

本文报道了AgGaS_2晶体Ⅱ类非共线相位匹配Q开关Nd:YAG激光泵浦CO_2激光参量上转换研究结果,用迭代法计算了相位失配因子△K=0时的最佳非共线夹角.当泵浦功率密度为6MW/cm~2和晶体长度为4.7mm时,功率转换效率达16.1%,并且首次采用硅雪崩光电二极管接收和频信号.     

掺锗硅基高非线性光纤超连续光源研究

利用非线性偏振旋转锁模掺铒光纤激光器和1100m长的掺锗硅基高非线性光纤制作了超连续光源,获得了从1150～1750nm的超宽带输出光谱,其中1150～1350nm波段光谱起伏小于3dB,1600～1700nm波段平坦度优于1dB,并有很好的向长波延展空间。光谱展宽的机理为孤子分裂与受激拉曼散射,而四波混频使光谱进一步展宽。     

水蒸气超高温热泵系统的实验研究

近年来以低温室效应(GWP)的制冷剂的蒸汽压缩式高温热泵一直是余热回收领域的研究热点.为获得更高的输出温度,本课题组搭建了一台采用自然工质水作为循环冷媒的超高温热泵样机并进行了实验测试.实验结果表明蒸发温度为80℃,冷凝温度从115℃升至145℃时,热泵的COP从4.88降至1.89.在85℃蒸发,117℃冷凝时,最高...     

斐索梯度折射率光纤透镜传感实验

采用LD泵浦的单纵模Nd：YVO4倍频激光器、梯度折射率光纤透镜等器件构成斐索梯度折射率光纤透镜传感实验仪．本文介绍了实验装置和实验原理，并给出了实验结果。