区域承接产业转移的产业空间双网络分析——基于金融发展、资源禀赋因素比较视角

利用社会网络分析法,对金融发展、资源禀赋影响下区域承接产业转移的产业空间双网络进行对比分析,结果显示:金融发展、资源禀赋两因素对产业空间网络均产生了正向作用。同时,在产业空间网络中我国各区域基本都具备承接产业转移发展的条件。进一步,经过QAP检验得出两网络呈正相关关系。最后,通过构建2-模网确定了影响我国区域承接产业转移的核心成员(省市、自治区)以及我国区域承接产业转移的合理路径,反映到政策上即发达区域资源禀赋的合理布局以及欠发达区域金融发展的大力支持是目前构建现代化产业体系的关键,本文的研究结论以期为我国区域承接产业转移提供理论借鉴。     

非线性发展方程的自相似解

本文着力于给出非线性发展方程的自相似解的一些最新的研究进展．借助于调和分析的方法(特别是利用Littlewood-Paley理论、时空估计等)，通过非线性发展方程的Cauchy问题的研究来获得自相似解．主要技术是将初始状态空间X推广到非自反的Banach空间(使得X包含那些具自相似结构的初始函数)，相应地将适定性中解在t=0处的连续性放宽成弱连续．另一方面，用Scaling的方法来分析时空可积空间的形式、非线性增长与空间X的选取等．这对非线性发展方程Cauchy问题的研究是至关重要的，它本质上给出了研究非线性发展方程Cauchy问题的工作空间．进而，对于自相似解的结构、自相似解作用(可以是某些整体解的大尺度极限)亦给出了一些具体的分析．     

最大度为4的图的无圈列表边染色

对于图G=(V(G),E(G)),如果一个映射φ:E(G)→{1,2,…,k},使得G中任意相邻的两边e₁,e₂满足φ(e₁)≠φ(e₂),并且G中不含有双色圈,则称φ为G的一个无圈边染色.对于给定的列表分配L={L(e)|e∈E(G)},如果存在图G的一个无圈边染色φ,使得对于任意边e∈E(G),均有φ(e)∈L(e),则称染色φ为G的一个无圈L-边染色.如果对于任意的列表分配L,当对所有的边e∈E(G)满足|L(e)|≥k时,图G均存在无圈L-边染色,那么称G是无圈k-边可选的.使图G无圈k-边可选的最小的正整数k,称为G的无圈列表边色数,用a’_l(G)表示.本文证明了对于最大度△≤4的连通图G,如果|E(G)|≤2|V(G)|-1,则a’_l(G)≤6,扩展了Basavaraju和Chandran文[J.Graph Theory,2009,61(3):192-209]的结果.     

Semi-synthesis of disulfide-linked branched tri-ubiquitin mimics

Ubiquitin (Ub) chain isopeptide bond mimics are useful molecules for biochemical and biophysical studies. Herein, we report the semi-synthesis of the disulfide-linked K11/K48-branched tri-Ub (Ub₃^11/48(S–S)), the first example of an isopeptide mimic for the branched Ub chains, which have recently emerged as an interesting category of Ub modifications. Our strategy comprised the E1-dependent synthesis of the Ub conjugate of aminoethanethiol, followed by disulfide formation with Ub(K11C, K48C). The structure of the synthetic isopeptide bond mimics was verified by the crystal structure of Ub₃^11/48(S–S). Deubiquitination and pulldown assays indicated that the synthetic Ub₃^11/48(S–S) could be hydrolyzed by linkage-specific deubiquitinases (K11-specific Cezanne and K48-specific OTUB1), and recognized by proteasomal ubiquitin receptor S5a.     

重症肌无力免疫吸附剂的制备及性能研究

重症肌无力患者体内致病毒素是乙酰胆碱的受体抗体.通过对载体材料的优化及对配基的筛选发现,使用质量分数为6%的纤维素球形载体,以环氧氯丙烷法活化并固定上L-色氨酸作为配基制备的血液灌流材料在静态吸附实验(1g吸附剂加入3mL病人血清,室温,3h)中可使抗体水平下降25%以上,吸附量达3.669×10^-3nmol/g,选择性较高,具有应用前景.     

Estimation on Local Energy Density in Relativistic Heavy Ion Collisions

Energy density for the central region in relativistic heavy ion collisionscan be estimated via the pseudora-pidity distribution of transverse energy. The way to estimate the local energy density for the centralregion in relativisticheavyion collisions is proposed, in which only final state particles emitted from the same source are included. Thcarrived energy density in NA49 experiments is about 1.03 GeV/fm3.     

Coexisting Condensates of Weakly Interacting Bose Gas in a Harmonic Trap

We study particles in a vortex state driven to a core state with lower energy and zero angular momentum by the trap potential asymmetries. We find that at T=0 when the role of the thermal gas can be ignored, there will be coexisting condensates. We also calculate the fluctuation of the number difference and argue that in certa/n range of the parameters the state of the whole system is the macroscopic quantum serf-trapping in the Josephson tunnelling regime.     

沙棘果碱提水溶多糖JS1的结构研究

沙棘（Hippophae rhamnoides L.）为胡颓子科（Elaeagnaceae）酸刺属的灌木或小乔木,它含有丰富的活性物质,具有明显的医用功效;同时已被大量用于水土保持和改善生态环境等方面,对其多糖结构的研究国内外尚未见报道。本文对沙棘果碱提水溶多糖JS1的结构进行了研究。     

采动岩体的流变与控制技术

指出采矿工程中岩体的稳定性研究焦点是破裂岩体的流变与控制技术,这给固体流变学研究带来严峻挑战和发展良机,本文较为全面地 采矿工程中巷道围岩变形,采场覆岩运动,岩层移动与围岩突出中的流变现象,以及与之相应的传统理论与控制技术,并为岩石流变学研究指出了新的发展方向。     

Dried Plasma Spot Based LC–MS/MS Method for Monitoring of Meropenem in the Blood of Treated Patients

Meropenem (MER) is widely used to treat complicated and serious infections. Therapeutic drug monitoring (TDM) provides a valid clinical tool to avoid suboptimal concentrations and dose–related adverse reactions. However, TDM seems to face challenges since the limited stability of MER in plasma makes transport difficult between clinics and laboratories. Dried plasma spot (DPS) sampling is an attractive but underutilized method for TDM that has the desired features of easy collection, storage, and transport, and overcomes known hematocrit (HCT) issues in dried blood spot (DBS) analysis. This study was designed to investigate a DPS–based liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for quantification of MER. The method was developed and validated for DPS and wet plasma samples. Calibration curves were linear (R² > 0.995) over the concentration range of 0.5–50 µg/mL. Overall accuracy and precision did not exceed 15% and no significant matrix effect was observed. MER has been more stable in DPS than in wet plasma samples. A comparison of DPS and wet plasma concentrations was assessed in 32 patients treated with MER. The results showed that there was no significant difference between the two methods. So the DPS method developed in this study is appropriate and practical for the monitor of MER in the daily clinical laboratory practice.