全文获取类型
收费全文 | 581627篇 |
免费 | 6346篇 |
国内免费 | 1755篇 |
专业分类
化学 | 317373篇 |
晶体学 | 8836篇 |
力学 | 24813篇 |
综合类 | 17篇 |
数学 | 65946篇 |
物理学 | 172743篇 |
出版年
2021年 | 4476篇 |
2020年 | 4957篇 |
2019年 | 5370篇 |
2018年 | 6715篇 |
2017年 | 6555篇 |
2016年 | 10447篇 |
2015年 | 6827篇 |
2014年 | 10235篇 |
2013年 | 25977篇 |
2012年 | 19402篇 |
2011年 | 23967篇 |
2010年 | 16622篇 |
2009年 | 16391篇 |
2008年 | 21913篇 |
2007年 | 21910篇 |
2006年 | 20388篇 |
2005年 | 18361篇 |
2004年 | 17033篇 |
2003年 | 15063篇 |
2002年 | 14786篇 |
2001年 | 16984篇 |
2000年 | 12920篇 |
1999年 | 10240篇 |
1998年 | 8441篇 |
1997年 | 8185篇 |
1996年 | 8073篇 |
1995年 | 7213篇 |
1994年 | 7098篇 |
1993年 | 6844篇 |
1992年 | 7774篇 |
1991年 | 7753篇 |
1990年 | 7505篇 |
1989年 | 7328篇 |
1988年 | 7302篇 |
1987年 | 7198篇 |
1986年 | 6848篇 |
1985年 | 8921篇 |
1984年 | 9136篇 |
1983年 | 7376篇 |
1982年 | 7676篇 |
1981年 | 7565篇 |
1980年 | 7077篇 |
1979年 | 7582篇 |
1978年 | 7954篇 |
1977年 | 7751篇 |
1976年 | 7611篇 |
1975年 | 7149篇 |
1974年 | 7042篇 |
1973年 | 7098篇 |
1972年 | 4960篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Kinetics and Catalysis - Boron and barium were employed as dopants for the VMgO system. The catalysts were characterized by ICP-OES, BET, IR, powder XRD, EDX, TPR-H2, TPD-NH3, XPS, and 51V MAS NMR.... 相似文献
82.
Anton M. Zeitlin 《Letters in Mathematical Physics》2015,105(2):149-167
83.
Chris H. Hill Agnete H. Viuff Samantha J. Spratley Stéphane Salamone Stig H. Christensen Randy J. Read Nigel W. Moriarty Henrik H. Jensen Janet E. Deane 《Chemical science》2015,6(5):3075-3086
Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the lysosomal enzyme β-galactocerebrosidase (GALC), which hydrolyzes the terminal galactose from glycosphingolipids. These lipids are essential components of eukaryotic cell membranes: substrates of GALC include galactocerebroside, the primary lipid component of myelin, and psychosine, a cytotoxic metabolite. Mutations of GALC that cause misfolding of the protein may be responsive to pharmacological chaperone therapy (PCT), whereby small molecules are used to stabilize these mutant proteins, thus correcting trafficking defects and increasing residual catabolic activity in cells. Here we describe a new approach for the synthesis of galacto-configured azasugars and the characterization of their interaction with GALC using biophysical, biochemical and crystallographic methods. We identify that the global stabilization of GALC conferred by azasugar derivatives, measured by fluorescence-based thermal shift assays, is directly related to their binding affinity, measured by enzyme inhibition. X-ray crystal structures of these molecules bound in the GALC active site reveal which residues participate in stabilizing interactions, show how potency is achieved and illustrate the penalties of aza/iminosugar ring distortion. The structure–activity relationships described here identify the key physical properties required of pharmacological chaperones for Krabbe disease and highlight the potential of azasugars as stabilizing agents for future enzyme replacement therapies. This work lays the foundation for new drug-based treatments of Krabbe disease. 相似文献
84.
85.
86.
Natalia L. Calvo Sebastian O. SimonettiRubén M. Maggio Teodoro S. Kaufman 《Analytica chimica acta》2015
Exposure of cimetidine (CIM) to dry heat (160–180 °C) afforded, upon cooling, a glassy solid containing new and hitherto unknown products. The kinetics of this process was studied by a second order chemometrics-assisted multi-spectroscopic approach. Proton and carbon-13 nuclear magnetic resonance (NMR), as well as ultraviolet and infrared spectroscopic data were jointly used, whereas multivariate curve resolution with alternating least squares (MCR-ALS) was employed as the chemometrics method to extract process information. It was established that drug degradation follows a first order kinetics. 相似文献
87.
88.
89.
90.
Journal of Structural Chemistry - Thermodynamic characteristics are calculated for aqueous alkanolamine solutions that are obtained by substituting alkyl radicals for the protons in the amino group... 相似文献