Synthesis of putative radioprotectors on the basis of cyclic isotioureas derivatives

The present work deals with the synthesis of sixteen compounds with putative inhibiting activity towards NO-synthase on the basis of 2-amino-2-thiazoline and 2-amino-5,6-dihydro-4H-1,3-thiazine.     

Dynamics of deformation of an elastic medium with initial stresses

The constitutive equations of motion of an elastic medium with given initial stresses are formulated in the form of a hyperbolic system of first order differential equations. Equations describing the propagation of small perturbations in a prestressed isotropic medium with an arbitrary dependence of the elastic strain energy on the strain tensor are derived, and equations for the quadratic dependence of elastic strain energy on the strain tensor are given.     

Thermal/hyperbaric heterocycloaddition of 1,4-dialkoxy-1,3-dienes: the de novo (E,Z) way to sugars

1-(Z)-Alkoxy-4-(E)-methoxybutadiene derivatives have been reacted with ethylgyoxylate and diethyl ketomalonate under thermal or hyperbaric conditions. They provide, with a total regioselectivity and fair to total endoselectivities, the expected dihydropyranic cycloadducts. Three of those pseudo-glycals have been converted in a few classical steps (deprotection, reduction, and dihydroxylation) into (racemic) allose, mannose, and gullose derivatives. The order of these three steps has a direct influence on the efficiency of the transformation and determines the stereochemistry of the final sugar.     

A pulsed time-of-flight mass spectrometer for liquid secondary ion mass spectrometry

The design and performance of a new time-of-flight mass spectrometer is reported. The instrument combines the advantages of a pulsed drawout TOF analyzer with a liquid secondary ion source. Differences from commercially available pulsed TOF analyzers (Wiley/McLaren type) are discussed with regard to operation with ion desorption from a liquid matrix.