The regio- and stereoselective addition of C(1)-ammonium enolates – generated in situ from aryl esters and the isothiourea catalyst (R)-BTM – to pyridinium salts bearing an electron withdrawing substituent in the 3-position allows the synthesis of a range of enantioenriched 1,4-dihydropyridines. This represents the first organocatalytic approach to pyridine dearomatisation using pronucleophiles at the carboxylic acid oxidation level. Optimisation studies revealed a significant solvent dependency upon product enantioselectivity, with only toluene providing significant asymmetric induction. Using DABCO as a base also proved beneficial for product enantioselectivity, while investigations into the nature of the counterion showed that co-ordinating bromide or chloride substrates led to higher product er than the corresponding tetrafluoroborate or hexafluorophosphate. The scope and limitations of this process are developed, with enantioselective addition to 3-cyano- or 3-sulfonylpyridinium salts giving the corresponding 1,4-dihydropyridines (15 examples, up to 95 : 5 dr and 98 : 2 er).The regio- and stereoselective addition of C(1)-ammonium enolates – generated in situ from aryl esters and the isothiourea catalyst (R)-BTM – to pyridinium salts allows the synthesis of a range of enantioenriched 1,4-dihydropyridines.相似文献
Melanoidins are composite biopolymers which consist of amino carbonyl compounds which are the major coloring and polluting elements of distillery effluent. In this study, a synthetic melanoidin was used as a model for natural melanoidins, the chief colorant of the effluent. Deportations of melanoidins were investigated using both natural adsorbents and constructed microbial consortia based adsorbents and denoting it using the adsorption isotherms and SEM analysis. A review enabled us to assess about the valuation of the prepared low cost adsorbent and microbial coated adsorbents and for the treatment of the synthetic melanoidin solution. Based on the performances, both Microbial Coated Commercially Activated Carbon (MCCAC) and Commercially Activated Carbon (CAC) were better when compared with the other adsorbents at lower melanoidin concentrations; however, at higher melanoidin concentration, MCCAC performed better. The utilization of CAC for the removal of melanoidins may be cost competitive; hence Microbial Coated Procured Prosopsis Activated Carbon (MCPPAC) can be used as a substitute for the removal systems. Therefore, the microbial coated adsorbents can be a remedy for the removal of color through expatriation of melanoidin from the distillery effluents. 相似文献
Zinc pyrithione is ubiquitous in commercial products particularly antidandruff shampoos. For the efficacy of zinc pyrithione therapeutic cleansers to be assessed accurately, the distribution of particles on the scalp needs to be visualized. Currently, no technique is available which provides the chemical specificity and sensitivity required. Here, we report application of fluorescence‐lifetime imaging microscopy (FLIM) for high‐contrast mapping of zinc pyrithione distribution on the scalp. Characterization of the zinc pyrithione emission by using both one‐photon excitation at five specific wavelengths and two‐photon excitation in the range of 740–820 nm revealed its FLIM fingerprint—a characteristic short average time‐weighted emission lifetime of ΤZnPT = 250 ps. Bandpass‐filtering FLIM signals at ΤZnPT enabled an efficient discrimination between the zinc pyrithione and major endogenous skin species in comparison with that of the conventional reflectance confocal microscopy. Our findings provide means for in vivo high‐sensitivity assaying and high‐contrast imaging of zinc pyrithione in biological systems. 相似文献
A highly proficient nonlinear optical compound Sodium Hydrogen Oxalate Monohydrate (SHOM) single crystal under semi organic category has been grown-up by the process of slow solvent evaporation. The triclinic structure and cell parameters of SHOM was revealed from X-ray diffraction analysis. The examination of FTIR was done to determine the existence of various functional groups present in the SHOM crystal. The mechanical stability is evaluated from Vicker's microhardness tester and related mechanical parameters were assessed. The multiple shot laser damage threshold was examined to be 2.65 GW/cm2. TG/DTA analysis is carried out to appraise the thermal limit of the grown material. The absorbance spectrum was analyzed from UV–vis analysis which verifies high transparency of the grown crystal and various optical constants were also estimated. The third order nonlinearity, two-photon absorption and self-defocussing effect of the grown material was established from the Z-Scan approach. The results favoring the materials suitability over nonlinear optical applications are reported. 相似文献
Summary: In this work, we report superior mass transport properties of polymers prepared by the covalent coupling of supermolecular carbon cages (e.g., fullerenes, bucky balls) to a poly(2,6‐dimethyl‐1,4‐phenylene oxide) (PPO) polymer. Dispersing the bucky balls into the polymer reduces gas permeability, whereas covalent bonding enhances permeability up to 80% in comparison to the pure PPO. Gas pair selectivity, however, is not compromised and stays constant.
Schematic representation of the PPO polymer membrane and the PPO‐covalently bonded C60 polymer membrane. 相似文献
The aim of this study was to investigate the cytotoxic activity of the Coriandrum sativum (C. sativum) ethanolic extract (CSEE) in neuroblastoma cells, chemically characterize the compounds present in the CSEE, and predict the molecular interactions and properties of ADME. Thus, after obtaining the CSEE and performing its chemical characterization through dereplication methods using UPLC/DAD-ESI/HRMS/MS, PM6 methods and the SwissADME drug design platform were used in order to predict molecular interactions and ADME properties. The CSEE was tested for 24 h in neuroblastoma cells to the establishment of the IC50 dose. Then, the cell death was evaluated, using annexin-PI, as well as the activity of the effector caspase 3, and the protein and mRNA levels of Bax and Bcl-2 were analyzed by ELISA and RT-PCR, respectively. By UHPLC/DAD/HRMS-MS/MS analysis, the CSEE showed a high content of isocoumarins-dihydrocoriandrin, coriandrin, and coriandrones A and B, as well as nitrogenated compounds (adenine, adenosine, and tryptophan). Flavonoids (apigenin, hyperoside, and rutin), phospholipids (PAF C-16 and LysoPC (16:0)), and acylglicerol were also identified in lower amount as important compounds with antioxidant activity. The in silico approach results showed that the compounds 1 to 6, which are found mostly in the C. sativum extract, obey the “Five Rules” of Lipinski, suggesting a good pharmacokinetic activity of these compounds when administered orally. The IC50 dose of CSEE (20 µg/mL) inhibited cell proliferation and promoted cell death by the accumulation of cleaved caspase-3 and the externalization of phosphatidylserine. Furthermore, CSEE decreased Bcl-2 and increased Bax, both protein and mRNA levels, suggesting an apoptotic mechanism. CSEE presents cytotoxic effects, promoting cell death. In addition to the promising results predicted through the in silico approach for all compounds, the compound 6 showed the best results in relation to stability due to its GAP value. 相似文献