Synthesis,Photophysics, and Self‐Assembly of Furan‐Embedded Heteroarenes

A series of pyrene/phenanthrene‐fused furan derivatives ( 1 – 8 ) were synthesized by a simple condensation reaction between pyrene‐4,5‐diketone/phenanthrenequinone and substituted phenol/naphthol in the presence of trifluoromethanesulfonic acid in 1,2‐dichlorobenzene heated at reflux. The formed compounds can emit strong blue light in organic solvents. Additionally, the self‐assembly behaviors of two of the compounds ( 3 and 5 ) were studied through re‐precipitation method and the resulting nanostructures were characterized by UV/Vis, fluorescence spectra, and field‐emission scanning electron microscopy (FESEM). The findings showed that the shape and size of compounds 3 and 5 could be tuned by the ratio of THF and hexadecyl trimethyl ammonium bromide (CTAB) solution in water.     

Dipeptidyl peptidase-IV activity assay and inhibitor screening using a gold nanoparticle-modified gold electrode with an immobilized enzyme substrate

Microchimica Acta - We report on an electrochemical biosensor for the determination of the activity of dipeptidyl peptidase-IV (DPP-IV), and on a method for screening the effect of its inhibitors....     

淀粉基聚合物胶束用作药物载体

两亲性聚合物能通过亲疏水作用自组装为核-壳结构,而这独特的优势已使其成为在肿瘤靶向药物缓释方面具有很好发展前景的药物载体.淀粉原材料来源丰富,价格低廉,同时具有良好的生物相容性和生物可降解性,故基于淀粉的两亲性聚合物胶束正引起越来越多研究者极大的关注.作为药物载体,淀粉基聚合物胶束不仅可以提高药物的水溶性、延长药物在体内的循环时间、降低副作用和通过增强渗透与滞留(EPR)效应提高药物在靶向部位的优先累积,还可以在淀粉骨架上引入一些刺激响应型的官能团实现胶束快速靶向释药的功能.因此,淀粉基聚合物胶束在用作药物载体方面有着广阔的发展潜力.本文结合本课题组目前的研究工作和近几年的相关报道对淀粉基聚合物胶束作为药物载体的最新研究进展做简要综述.     

ChemInform Abstract: First‐Principles Molecular Dynamics Investigation on Na3AlF6 Molten Salt.

The partial radial distribution function, coordination numbers, bond angles, F atoms type, self‐diffusion coefficient, viscosity, and ionic conduction of molten Na₃AlF₆ are investigated by first‐principles molecular dynamics simulation.     

Two‐Dimensional Layered Heterostructures Synthesized from Core–Shell Nanowires

Controlled stacking of different two‐dimensional (2D) atomic layers will greatly expand the family of 2D materials and broaden their applications. A novel approach for synthesizing MoS₂/WS₂ heterostructures by chemical vapor deposition has been developed. The successful synthesis of pristine MoS₂/WS₂ heterostructures is attributed to using core–shell WO_3?x/MoO_3?x nanowires as a precursor, which naturally ensures the sequential growth of MoS₂ and WS₂. The obtained heterostructures exhibited high crystallinity, strong interlayer interaction, and high mobility, suggesting their promising applications in nanoelectronics. The stacking orientations of the two layers were also explored from both experimental and theoretical aspects. It is elucidated that the rational design of precursors can accurately control the growth of high‐quality 2D heterostructures. Moreover, this simple approach opens up a new way for creating various novel 2D heterostructures by using a large variety of heteronanomaterials as precursors.     

Multistimuli‐Responsive,Moldable Supramolecular Hydrogels Cross‐Linked by Ultrafast Complexation of Metal Ions and Biopolymers

A new type of multistimuli‐responsive hydrogels cross‐linked by metal ions and biopolymers is reported. By mixing the biopolymer chitosan (CS) with a variety of metal ions at the appropriate pH values, we obtained a series of transparent and stable hydrogels within a few seconds through supramolecular complexation. In particular, the CS–Ag hydrogel was chosen as the model and the gelation mechanism was revealed by various measurements. It was found that the facile association of Ag⁺ ions with amino and hydroxy groups in CS chains promoted rapid gel‐network formation. Interestingly, the CS–Ag hydrogel exhibits sharp phase transitions in response to multiple external stimuli, including pH value, chemical redox reactions, cations, anions, and neutral species. Furthermore, this soft matter showed a remarkable moldability to form shape‐persistent, free‐standing objects by a fast in situ gelation procedure.     

Luminescence Properties of Ca2Ga2SiO7:RE Phosphors for UV White‐Light‐Emitting Diodes

A series of Eu²⁺‐, Ce³⁺‐, and Tb³⁺‐doped Ca₂Ga₂SiO₇ phosphors is synthesized by using a high‐temperature solid‐state reaction. The powder X‐ray diffraction and structure refinement data indicate that our prepared phosphors are single phased and the phosphor crystalizes in a tetrahedral system with the ${P\bar 42m}$ (113) space group. The Eu²⁺‐ and Ce³⁺‐doped phosphors both have broad excitation bands, which match well with the UV light‐emitting diodes chips. Under irradiation of λ=350 nm, Ca₂Ga₂SiO₇:Eu²⁺ and Ca₂Ga₂SiO₇:Ce³⁺, Li⁺ have green and blue emissions, respectively. Luminescence of Ca₂Ga₂SiO₇:Tb³⁺, Li⁺ phosphor varies with the different Tb³⁺ contents. The thermal stability and energy‐migration mechanism of Ca₂Ga₂SiO₇:Eu²⁺ are also studied. The investigation results indicate that the prepared Ca₂Ga₂SiO₇:Eu²⁺ and Ca₂Ga₂SiO₇:Ce³⁺, Li⁺ samples show potential as green and blue phosphors, respectively, for UV‐excited white‐light‐emitting diodes.     

An ultra high performance liquid chromatography with tandem mass spectrometry method for plasma and cerebrospinal fluid pharmacokinetics of rhein in patients with traumatic brain injury after administration of rhubarb decoction

Damage of blood–brain barrier is a common result of traumatic brain injury. This damage can open the blood–brain barrier and allow drug passage. An ultraperformance liquid chromatography with tandem mass spectrometry method was established to determine the concentration of rhein in the biofluids (plasma and cerebrospinal fluid) of patients with a compromised blood–brain barrier following traumatic brain injury after rhubarb administration. Furthermore, the pharmacokinetic profiles were analyzed. A triple‐quadruple tandem mass spectrometer with electrospray ionization was used for rhein detection. The mass transition followed was m/z 283.06→239.0. The calibration curve was linear in the concentration range of 10–8000 ng/mL for the biofluids. The intra‐ and interday precisions were less than 10%. The relative standard deviation of recovery was less than 15% in biological matrices. The pharmacokinetic data showed that rhein was rapidly transported into biofluids, and exhibited a peak concentration 1 h after rhubarb administration. The elimination rate of rhein was slow. The AUC_{cerebrospinal fluid}/AUC_plasma (AUC is area under curve) of rhein was approximately 17%, indicating that portions of rhein could pass the impaired blood–brain barrier. The method was successfully applied to quantify rhein in the biofluids of all patients. The data presented can help to guide clinical applications of rhubarb for treating traumatic brain injury.