层状MAgTeS3 (M＝K, Rb)的溶剂热合成与表征

以硫醇为螯合剂, 在溶剂热条件下合成了两种层状硫代亚碲酸盐KAgTeS₃ (1)和RbAgTeS₃ (2). X射线单晶解析表明, 1和2是类质同晶化合物. 在晶体结构中, 银硫四面体通过共用顶点形成无限的平行链, 在相邻链中银硫四面体取向相反, 这些链与链由三角锥配位的碲互相连接形成阴离子层状结构, 阳离子在阴离子层间. 1的结晶学数据为: M_r＝370.75, P2₁/c, a＝0.73639(6) nm, b＝1.06468(8) nm, c＝0.85203(6) nm, β＝106.4640(10)°, V＝0.64062(8) nm³, Z＝4, R(F)＝4.44%, wR(F²)＝11.66%. 2的结晶学数据: M_r＝417.12, P2₁/c, a＝0.75531(12) nm, b＝1.07076(7) nm, c＝0.8583(2) nm, β＝106.497(6)°, V＝0.66558(19) nm³, Z＝4, R(F)＝6.00%, wR(F²)＝15.43%. DSC及紫外-可见漫反射光谱研究表明, 这两种化合物为半导体, 并具有很好的热稳定性.     

Synthesis of a Photolabeling Probe for the Study of Antiviral Mechanism of Ribavirin

Ribavirin has been used in urgency to treat SARS patients recently. In order to study its antiviral mechanism by photolabeling approach, we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxiamide 1 as a photolabeling probe of ribavirin. The azidotriazole nucleoside showed rapid and clean photochemical reaction, suggesting that 1 is a promising probe to study the antiviral mechanism ofribarivin by photolabeling.     

纳米ZrO2的合成对负载Ni催化剂的CH4/CO2重整反应的影响

采用共沉淀法、醇热合成法和干法分别合成了纳米ZrO2（ZrO2 CP、ZrO2 ET和ZrO2 S），用XRD、 BET、SEM等对其结构和表面性质进行表征，以CH4/CO2重整为探针反应研究了不同方法合成的纳米ZrO2负载Ni催化剂的催化性能，并与载体的物化性质进行了关联。实验结果表明，以干法合成的纳米介孔ZrO2 S具有较大的比表面积（133m2/g）和较好的孔径分布(4.9nm)，Ni/ZrO2 S催化剂在CH4/CO2重整反应中表现出较好的催化性能。     

1,3-二羧甲基咪唑盐酸盐热分解过程研究

离子液体是继超临界流体之后的一类新的绿色溶剂,因其具有一系列独特的性质,作为溶剂和反应介质已广泛应用于有机合成、催化反应工程、电化学、分离分析等领域.随着研究和应用的逐渐深入,仅仅将离子液体作为溶剂和反应介质已不能满足要求,使离子液体带上某些官能团,从而赋予其特定的功能,是相关领域的一个研究热点.1,3-二取代咪唑盐是一类常用的离子液体,对其功能化具有重要意义.1,3-二羧甲基咪唑的制备简单,将它与不同的酸如盐酸、磷酸、硼酸等进行反应,可得到对称二羧甲基取代的咪唑盐.这类咪唑盐作为缩聚单体与二醇或二胺反应,可得到每个重复链节上都含有咪唑阳离子的新的功能性聚酯或聚酰胺;如果用其掺杂导电聚苯胺,因其挥发性低则有可能大大提高聚苯胺的导电寿命.     

球笼烯（C_（60）／C_（70）载体钕系催化丁二烯聚合的研究

球笼烯（Ｃ_（６０）／Ｃ_（７０）载体钕系催化丁二烯聚合的研究赵春英，陈滇宝，仲崇祺，董文寰，徐玲，唐学明（青岛化工学院高分子材料系青岛２６６０４２）杨海滨，李明辉，邹广田（吉林大学超硬材料国家重点实验室长春１３００２３）关键词球碳载体钕系催化剂，聚丁...     

Self-assembling of helical poly(phenylacetylene) carrying L-valine pendants in solution, on mica substrate, and on water surface

In the present work, we investigated self-assembling of a poly(phenylacetylene) carrying L-valine pendants (PPA-Val) in a water/methanol solution, upon evaporation of the solution on mica, and on the water surface. With intercalation of a fluorescence probe of Ru(phen)2(dppx)2+ (phen = 1,10-phenanthroline, dppx=7,8-dimethyldipyridophenazine) into the hydrophobic cavities associated by the PPA-Val chains, their helical structures were directly detected in solution with an in situ fluorescence microscope. Helical aggregates were observed with AFM upon evaporation of the solvents, suggesting that the helical structures in the solution are the building blocks of the helical aggregates. Self-assembling structures of PPA-Val on the water surface were, however, very different from that formed upon evaporation of its THF solution on the mica surface. The polymer chains associated into a monolayer of extended fibers on the water surface, whereas superhelical fibers formed on the mica surface. Water molecules play a critical role in inducing the polymer to form diverse morphological structures in its bulk solution and on its surface. In solution, the isotropic hydrophobic effect drove the polymer chains to form superhelical aggregates, while on the water surface, the hydrophobic effect concentrated mainly on the lateral part of the polymer, thus giving a monolayer of extended fibers.     

The Surface Imprinted Polystyrene Beads Prepared via Emulsion Templates

In this paper, the surface imprinted cross-linked polystyrene beads were prepared via suspension polymerization with styrene (St), divinylbezene (DVB), polyvinyl alcohol (PVA1788),the mixture of Span 85 and xylene or the mixture of Span 85 and paraffin as monomer,cross-linking agent, dispersion stabilizer and templates, respectively. The results indicate that there are dense cavities on the surface of beads, and the diameter and density of cavity are related with the composition and amount of emulsion template. The forming mechanism of cavity from thermodynamics and dynamics was proposed.     

Synthesis of 5-ethynylorotic acid

Condensation of 2,4-dimethoxy-5-iodo-6-carbomethoxypyrimidine ( 10 ) with copper (I) 3-tetrahydropyranyloxyprop-1-ynide ( 4 ) afforded 2,4-dimethoxy-5-(3′-tetrahydropyranyloxyprop-1′-yn)-6-carbomethoxypyrimidine ( 11 ), which was hydrolyzed to produce 2,4-dimethoxy-5-(3′-hydroxyprop-1′-yn)-6-carbomethoxypyrimidine ( 12 ). Oxidation of 12 with dimethyl sulfoxide-oxalyl chloride reagent gave the acetylenic aldehyde ( 13 ), which on treatment with sodium methoxide in dry tetrahydrofuran yielded 2,4-dimethoxy-5-ethynyl-6-carbomethoxypyrimidine ( 14 ). The trimethylsilyl derivative ( 15 ) was deprotected by sequential treatment with iodotrimethylsilane and aqueous sodium hydroxide, leading to the formation of 5-ethynylorotic acid ( 1 ).     

(Pd-Cu)/C上苯乙烯氧化羰化合成肉桂酸甲酯的研究

在常压130℃下研究了Pd-Cu催化剂组成,反应温度,少量添加剂和原料气中O_2含量等对苯乙烯氧化羰化合成肉桂酸甲酯的影响,并对催化剂的形、相态进行表征.发现O_2有双重作用;O_2不仅使Pd-Cu之间的价态循环,而且能抑制反应过程中饱和苯丙酸甲酯的生成.指出催化反应中Pd-Cu之间的催化协同效应促进了产物的生成.初步讨论了本反应的机理.     

Design,Synthesis, and Characterization of Photolabeling Probes for the Study of the Mechanisms of the Antiviral Effects of Ribavirin

Ribavirin, the only small molecule available so far for treating hepatitis‐C‐virus infection, was recently used in an emergency context to treat patients with severe acute respiratory syndrome (SARS) in the early stages of the disease. To study the mechanisms responsible for the antiviral effects of ribavirin by using a photolabeling approach, we designed, synthesized, and characterized the azidotriazole nucleosides 1 and 2 as photolabeling probes of ribavirin. These probes were synthesized either by performing nucleophilic substitution of the corresponding bromotriazole nucleoside with NaN₃ (Scheme 2) or by directly coupling the azidotriazole with the protected ribose sugar (Scheme 4). The azidotriazole nucleosides 1 and 2 showed a fast, clear‐cut photochemical reaction, which suggests that they are promising candidates for use in photolabeling studies.