N—乙基—α—甲基—间（三氟甲基）苯乙胺的合成

本文报道了一种新的简便的合成Ｎ－乙基α－甲基－间苯乙胺的方法。方法以三氟甲苯为原料，经氯甲基化，Ｇｉｇｎａｒｄ及Ｌｅｕｃｋａｒｔ反应后得目标物，具有原料价廉易得，毒性较小，反应条件温和，工艺流程较短等特点。     

Parallel solution combustion synthesis for combinatorial materials studies

A parallel solution combustion synthesis technique was developed for combinatorial materials studies. The vigorous combustion reactions were successfully limited in the microreactors by using a substrate-net-mask microreactor system and the lowest adoptable furnace temperature. Using this technique, a luminescent materials library of Y3Al5O12/Tb(chi) was synthesized with the aid of an ink-jet delivery system. Structure and luminescence characterizations were implemented using X-ray diffraction and UV/X-ray spectroscopies, respectively. The results show that this technique is reliable and applicable to combinatorial study of powder materials with high synthesis temperature.     

High-resolution Hadamard transform microscope fluorescence imaging: quantifying the DNA content in single cells

This study presents a novel miniaturized Hadamard transform fluorescence imaging microscope, by combining a conventional fluorescence microscope with Hadamard transform multiplexing encoding using a one-dimensional movable mask to realize spatial resolution and a linear CCD for multichannel detection. The microscope can provide high-resolution automatically-generated 0–255 gray level HT images for morphological analysis and visualization of a single cell, and normalized HT images for cellular quantitative measurements. The microscopes imaging capability was applied to measure the DNA content in human lymphocyte, chicken erythrocyte and eel erythrocyte, and a comparative study was performed. The results show that the calibrated DNA content in a chicken erythrocyte is 2.32 pg when human lymphocyte is used as the standard, and eel erythrocyte may be a potentially reliable and novel standard for determining DNA contents in other species because it has a stable DNA value of 2.06 pg, with a CV of 4.3% when 20 eel erythrocytes are measured. The results also demonstrate that the HT imaging microscope should be valuable in the fields of medicine and cell biology.     

Agonist–PPARγ interactions: Molecular modeling study with docking approach

Docking simulation of 18 agonists with the ligand binding pocket (LBP) of PPARγ has been performed. The binding conformations and binding affinities of these agonists were obtained by use of the flexible docking protocol FlexX. Test compound calculations indicated that FlexX can reproduce the binding conformation of the crystal structure (root mean square deviation = 1.43 Å); moreover, the predicted binding affinities correlate well with the activities of these agonists. The interaction model and pharmacophore of PPARγ agonists were derived and the difference in biologic activities of these agonists can be well explained. The PPARγ agonists must have both polar head and the hydrophobic tail, which form hydrogen bonds and hydrophobic contacts with hydrophilic and hydrophobic regions of the LBP of PPARγ, respectively. In addition, a suitable linker is also necessary. © 2003 Wiley Periodicals, Inc. Int J Quantum Chem 93: 405–410, 2003     

二氧化碳同环氧丙烷交替共聚用催化剂的研究

探讨了有机金属催化剂的组成及其对二氧化碳同环氧丙烷交替共聚产物结构的影响,发现二乙基锌—助剂体系的催化活性按如次顺序递降:二乙基锌—连苯三酚>二乙基锌—间苯二酚>二乙基锌—对苯二胺>二乙基锌—亚乙基脲。若用三异丁基铝代替二乙基锌同连苯三酚构成催化剂,则失去对二氧化碳同环氧丙烷交替共聚反应的活性同时,著者发现二乙基锌—二元芳胺催化体系与二乙基锌—二元酚催化体系的催化活性规律完全不同。     

Synthesis of porphyrin-appended terpyridine as a chemosensor for cadmium based on fluorescent enhancement

The design and synthesis of a porphyrin-appended terpyridine, 5-(4-([2,2′:6′,2″]-terpyridin-4-yl-carboxyamidyl)phenyl)-10,15,20-triphenylporphyrin (H₂TPPTPy) and its application as potential fluoroionophore for recognition of metal ions are reported. For preparation of the fluoroionophore, a novel simple strategy with improved total yield has been applied for the synthesis of 2,2′:6′,2″-terpyridine-4′-carboxylic acid as a ligand. H₂TPPTPy shows chelation-enhanced fluorescence effect with cadmium ion via the interruption of photoinduced electron transfer (PET) process, which has been utilized as the basis of the fabrication of the Cd(II)-sensitive fluorescent chemosensor. The analytical performance characteristics of the proposed Cd(II)-sensitive chemosensor were investigated. It shows a linear response toward Cd(II) in the concentration range of 3.2 × 10⁻⁶ to 3.2 × 10⁻⁴ M with a limit of detection of 1.2 × 10⁻⁶ M. The chemosensor shows good selectivity for Cd(II) over a large number of cations, such as alkali, alkali earth and transitional metal ions except Cu(II) and Zn(II). The sensor has been used for determination of Cd(II) in water samples with satisfactory recoveries.     

表面活性剂对纤维素接枝共聚物溶液粘度性质的影响

研究了阴离子十二烷基硫酸钠(SDS)、阳离子十六烷基三甲基溴化铵(CTAB)和非离子聚乙二醇辛基苯基醚(OP)等三种不同类型的表面活性剂对疏水化水溶性两性纤维素接枝共聚物(CGAO)溶液粘度性质的影响.结果表明,在SDS和OP的临界胶束浓度(cmc)附近，CGAO溶液粘度最大，SDS引起CGAO粘度的变化大于OP；即使在CTAB的cmc附近，随着CTAB浓度的增加，CGAO的粘度一直呈下降趋势；非疏水改性的纤维素接枝共聚物的溶液粘度随SDS或CTAB浓度的增加而下降，但几乎不随OP浓度的增大而变化.此外，通过凝胶渗透色谱法测得的保留时间证实了SDS、CTAB和OP与CGAO之间的疏水缔合作用.     

Resonance Rayleigh scattering technology as a new method for the determination of the inclusion constant of beta-cyclodextrin

The interaction of procaine hydrochloride and beta-cyclodextrin in aqueous solution was studied using resonance Rayleigh scattering technology. The molar ratio of the inclusion complex was 1:1 established by spectrophotometry. The resonance Rayleigh scattering technology was first applied in the determination of the beta-cyclodextrin inclusion constant. The inclusion constant of procaine hydrochloride beta-cyclodextrin complex Kf is 1.23 x 10(2) and 1.27 x 10(2) l mol(-1) for method I and 1.15 x 10(2) and 1.21 x 10(2) l mol(-1) for method II. These determination results were in correspondence with the results of the spectrophotometric and fluorescence methods. Therefore, the resonance Rayleigh scattering method can be used as a new technology for the determination of the inclusion constant.     

Dielectric properties and frequency response of self-assembled monolayers of alkanethiols

This paper presents dielectric properties of alkanethiol self-assembled monolayers (SAMs) under an ac electric field. Using a Hg-SAM/SAM-Hg junction, we measured the ac impedance of alkanethiol SAMs using a sinusoidal perturbation of 30 mV (peak-to-peak) with frequency ranging from 1 Hz to 1 MHz at zero bias. Semicircles at higher frequencies and at middle frequencies along with Warburg lines at lower frequencies were observed in complex plane impedance plots, that is, Nyquist plots. The frequency response of SAMs was analyzed by modeling the junction using an equivalent circuit and fitting the Nyquist plots. The semicircles at higher frequencies are attributed to the effect of the SAM/SAM interfaces, and the ones at middle frequencies are attributed to the effect of alkanethiol SAMs. The comparison in the plots of the imaginary part of the impedance Z against frequency for the bare Hg electrodes (in pure ethanal) and the SAM-covered Hg electrodes (in alkanethiol solution) supports the analysis. The Warburg lines are attributed to a certain ionic impurity. The dielectric loss spectra are further analyzed. Chain-length-dependent peaks, which correspond to different relaxation mechanisms, at higher frequencies and middle frequencies were observed in the spectra of the dissipation factor (tan delta vs frequency). The peaks move to small frequency with the increase of chain length of alkanethiols. Using a correlation of peak position with the chain length, we then derived active energies of 39-99 meV for alkanethiol SAMs of C7-C18 under an ac electric field.