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排序方式: 共有196条查询结果,搜索用时 15 毫秒
91.
The synthesis of caged NADP analogues 18, 19, and 20 has been accomplished by utilizing the transglycosidase activity of solubilized NAD glycohydrolase (porcine brain) to incorporate caged nicotinamides 2, 3, and 4 into NADP. The synthesis of several nicotinamides modified at the carboxamide with o-nitrobenzyl photolabile groups is demonstrated as well as their potential for enzymatic transglycosidation. These results further demonstrate the feasibility of direct enzymatic transglycosidation of sterically hindered substrates into NAD(P), although high nicotinamide analogue water solubility was found to be a necessary trait for yield enhancement with certain analogues. Caged analogues were surveyed under aqueous conditions for net NADP photorelease, while the UV and fluorescent properties of both analogues and their photobyproducts were assessed for compatibility with systems that rely on optical monitoring of enzyme activity. A highly water-soluble alpha-methyl-o-nitrobenzyl group 8 was developed for the synthesis of 20 in order to enhance net NADP photorelease. Compound 20 demonstrated a high 75% net NADP photoreleased without substantial UV optical blackening or fluorescent byproducts. Analogues 18 and 19 were shown by ESI/MALDI-MS to photogenerate primarily adducts of NADP with deleterious UV and fluorescent properties. Our work stresses the superior release properties conferred by alpha-methyl substitution on aqueous carboxamide photorelease from o-nitrobenzyl compounds. 相似文献
92.
The coordination compound [Co(urea)6](NO3)2 was synthesized and physico-chemically characterized. The thermal decomposition carried out in dynamic air and inert atmosphere
under non-isothermal conditions has been investigated by means of combined thermogravimetry/mass spectrometry, X-ray diffraction,
IR and UV-VIS spectroscopy as well as magnetic measurements. The course of the thermal decomposition starts with two-phase
transitions (melting and a Oh→Tdconfiguration change of the Co2+ ion) and continues with seven mass loss steps. According to the thermogravimetric and magnetic investigations a dimeric compound,
[Co(biuret)(NCO)]2(NO3)2, is assumed to arise. Up ~250°C, an oxohydroxide nitrate intermediate is formed and a gradual oxidation of the Co2+ ions is observed. At 550°C, Co3O4 with mean crystallite sizes of ~150 Ĺ is identified.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
93.
A TG, DTG and DTA study of three polynuclear coordination compounds,containing Al(III)-Mg(II), namely (NH4)4[Al2Mg(C4O5H4)4(OH)4]?2H2O,(NH4)4[MgAl2(C4H4O6)4(OH)4]?3H2Oand (NH4)2[Al2Mg(C6O7H11)5(OH)5]?3H2O,has been reported together with the associated thermal decomposition mechanismrationalized in terms of intermediate products. As decomposition end-product,magnesium-aluminum spinel is obtained. The values of MgAl2O4mean crystallite size depend on the anionic ligand contained by the precursorcompound, varying in the order: malate (143 Å) ligand contained by theprecursor compound, varying in the order: malate (143 Å) 相似文献
94.
Kurunczi L Seclaman E Oprea TI Crisan L Simon Z 《Journal of chemical information and modeling》2005,45(5):1275-1281
A homogeneous collection of 45 estrogen agonist derivatives with relative binding affinities measured to the estrogen receptor from Ratus norvegicus was used. The quantitative structure-activity relationships were derived using an improved minimal topologic difference (MTD) method in a partial least-squares (PLS) variant. The spatially assigned analysis of fragment properties can provide receptor site maps, within the limits of the existing series. A steric misfit was found for the steroidal position 2; benefic hydrophobic and van der Waals (enhanced by high polarizability) interactions were found for the 17alpha-CH=CH-X group. MTD-PLS mapping results are confirmed by the experimentally derived estradiol-estrogen receptor binding site contacts (based on X-ray crystallography). Our results suggest that this MTD-PLS method can yield useful results for interactions with receptors of unknown 3D structure and, generally, for the steric rigidity of receptor sites. 相似文献
95.
Oana Carp Luminita Patron G. Pascu Ioana Mindru N. Stanica 《Journal of Thermal Analysis and Calorimetry》2006,84(2):391-394
Nickel–zinc ferrites have been synthesized via thermal decomposition of polynuclear coordination compounds containing as ligand the anion of malic acid, namely (NH4)[Fe2NixZn1–x(C4H4O5)(OH)3]·nH2O (x =0.25, 0.5 and 0.75, n=3 and 5). A comparison between the thermal behaviour of the studied polynuclear coordination compounds is inferred. Fe2NixZn1–xO4 (n=0.25, 0.5 and 0.75) ferrites with mean particle sizes of 65–85 Å and free from other phases are formed after a heating treatment of only one hour at 500°C. 相似文献
96.
Physico-chemical properties of Chitosan films 总被引:1,自引:0,他引:1
Luminita Balau Gabriela Lisa M. I. Popa V. Tura V. Melnig 《Central European Journal of Chemistry》2004,2(4):638-647
Chitosan films obtained by dry phase inversion were prepared from an aqueous solution of chitosan in acetic acid. The films,
of thickness less than 20 μm, were transparent, very flexible and had smooth surfaces. Increasing the film thickness induced
an increase of the internal tensions and the consequent formation of a rough surface. Structural investigations by X-ray diffraction
and Fourier transform IR analysis, showed that the chitosan films, as prepared, are amorphous. Further annealing to evaporate
acetic acid and water traces, changed the amorphous phase into a more ordered phase, characterized by diffraction peaks at
2θ values of 9, 17, 20 and 23 degrees. Thermal investigations by TG, DTG, and DTA revealed that the decomposition of the chitosan
films as prepared proceeds in two stages, starting from 180°C and 540°C. 相似文献
97.
Visinescu D Toma LM Lloret F Fabelo O Ruiz-Pérez C Julve M 《Dalton transactions (Cambridge, England : 2003)》2008,(31):4103-4105
Two cyano-bridged M(III)Mn(III) [M = Fe () and Cr ()] ferrimagnetic chains are reported; exhibits metamagnetism with two critical fields of 1250 G and 2.0 T which correspond to the overcoming by the applied dc field of the inter- and intrachain magnetic interactions, respectively. 相似文献
98.
Moldovan N Lönnecke P Silaghi-Dumitrescu I Silaghi-Dumitrescu L Hey-Hawkins E 《Inorganic chemistry》2008,47(5):1524-1531
The synthesis and characterization of 10-(o-alkoxyphenyl)phenoxarsines 2-ROC6H4As(C6H4)2O (R = H, Me, and Pri, As(C6H4)2O = phenoxarsine) and their platinum(II) and palladium(II) complexes cis-[PtCl2{2-PriOC6H4As(C6H4)2O-kappaAs}2] (1), trans-[PdCl2{2-PriOC6H4As(C6H4)2O-kappaAs}2] (2), cis-[PtCl2{2-HOC6H4As(C6H4)2O-kappaAs}2] (3), cis-[PdCl2{2-HOC6H4As(C6H4)2O-kappaAs}2] (4), cis-[PtI2{2-MeOC6H4As(C6H4)2O-kappaAs}2] (5), and trans-[PdCl2{2-MeOC6H4As(C6H4)2O-kappaAs}2] (6) are reported. The chelate complex cis-[Pt{2-OC6H4As(C6H4)2O-kappaAs,O}2] (7) is also described. The molecular structures of 1-4 and 7 were determined. The short As...O intramolecular interaction found in complexes 1-4 in the solid state was also verified by calculations at the B3LYP/LANL2DZ level for complex 2 and for 10-(o-isopropoxyphenyl)phenoxarsine in the gas phase, and this suggests that the interaction is a characteristic of the ligand rather than a packing effect. Calculations at the B3LYP/LANL2DZ and Oniom(B3LYP/LANL2DZ:uff) levels for complexes 1-4 showed that the solvent plays a crucial role in the crystallization (through geometry constraints) of the kinetically stable cis isomers. 相似文献
99.
Duma L Abergel D Tekely P Bodenhausen G 《Chemical communications (Cambridge, England)》2008,(20):2361-2363
The suitability of fast MAS solid-state NMR spectroscopy for probing (1)H chemical shift anisotropy of hydrogen-bonded species has been demonstrated. 相似文献
100.
Results are presented on the thermal behaviour of two derivatives of malic acid. The decomposition intermediates obtained at about 400?C were identified as derivatives of malonic acid. For some individual thermal decomposition steps, the values of the non-isothermal kinetic parameters were determined. 相似文献