含吲哚核端基多甲川菁染料的合成及性能

我们曾合成了具有桥环的硫三碳菁及多甲川苯乙烯菁,并测定了光学性能。本文报道吲哚环为端基的桥链三碳菁和四甲川苯乙烯菁的合成及在有机溶剂中电子吸收光谱及溶解性能的测定。所用仪器同前,7种多甲川菁染料的合成反应如下:     

Self-assembly of highly oriented one-dimensional h-WO3 nanostructures

A new self-assembled and highly oriented one-dimensional single-crystal nanostructure of WO3 with hexagonal form was successfully prepared by a mild, solution-based colloidal approach.     

ULTRASONICALLY DISPERSED POTASSIUM AS DEPROTONATING AND COUPLING AGENT──SYNTHESIS OF 1，6－DINITRILES IN SITU

ＵＬＴＲＡＳＯＮＩＣＡＬＬＹ　ＤＩＳＰＥＲＳＥＤ　ＰＯＴＡＳＳＩＵＭ　ＡＳ　ＤＥＰＲＯＴＯＮＡＴＩＮＧ　ＡＮＤ　ＣＯＵＰＬＩＮＧ　ＡＧＥＮＴ──ＳＹＮＴＨＥＳＩＳ　ＯＦ　１，６－ＤＩＮＩＴＲＩＬＥＳ　ＩＮ　ＳＩＴＵＵＬＴＲＡＳＯＮＩＣＡＬＬＹＤＩＳＰ...     

含1,3-亚丙基冠醚的合成

为了进一步研究亚丙基冠醚的络合行为,合成了三种含1,3-亚丙基冠醚,即2,3-苯并-1,4,7,11-四氧-环十三-2-烯(苯并-13-冠-4)(1)、2,3-苯并-1,4,8,11,14-五氧-环十七-2-烯(苯并-17-冠-5)(2)、2,3-苯并-1,4,7,10,14,17-六氧-环十九-2-烯(苯并-19-冠-6)(3)。通过元素分析、红外光谱、质谱、核磁共振谱和 X-衍射晶体结构分析,确证了它们的结构。     

The synthesis and crystal structure of metal complexes S-alkyl-N-(ferrocenyl-1-methyl-methylidene)-dithiocarbazate and the study on their quenching the luminescence ofruthenium(bipyridine)_~3(2+)

The cobalt, nickel, copper, zinc and cadmium complexes of S-methyl-N-(ferrocenyl-l-methyl-methylidene)-dithiocarbazate (H-LSM) and S-benzyl-N-(ferrocenyl-l-methyl-methylidene)-dithiocarbazate (H-LSB) were synthesized and the crystal structure of Cd[Fe-C(CH3) = NNCSS. (CH3)]2 was solved by X-ray diffraction. The crystal is in the orthorhombic system with space group Pbca, cell parameters a=19.741(3), b=19.924(5), c=15.452(4) A, and the final factors of R=0.032. The study on quenching the luminescence of Ru(bpy)3 by those complexes showed that bimolecular quenching constants obtained from the Stern-Vohner constant and the excited-state lifetime were related to the redox potential of the quencher. Linear relationship is shown in the plot of logkq vs. E1/2(Q+/Q). The main factor which influences the quenching rate constant and the redox potential is the coordinating ability of the metal in the complex.     

An affinity-based probe for the proteomic profiling of aspartic proteases

We have developed an affinity-based probe for the proteomic profiling of aspartic proteases. Our probe was shown to be selective towards aspartic proteases over other proteins. It was also shown that the strategy may be used to label selectively aspartic proteases in the presence of a large excess of other proteins, thus making it useful for future proteome profiling experiments.     

Total synthesis of methyl protodioscin: a potent agent with antitumor activity

Methyl protodioscin (1), otherwise known as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-d-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22-methoxy-25(R)-furost-5-ene-3 beta,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.     

手性毛细管色谱法测定人尿中美芬妥英对映体的含量及其在代谢分型中的应用

 采用手性毛细管色谱柱和ＦＩＤ检测器建立了人尿中美芬妥英（ＭＰ）对映体的定量分析方法。尿样用二氯乙烷提取，用酸、碱洗涤得以纯化，测得各对映体的最低检测限为６０μｇ／Ｌ。在１１５～６９０μｇ／Ｌ浓度范围内，标准曲线呈良好的线性关系，ｒ＞０．９９，日内、日间精密度ＲＳＤ＜６．５％，Ｓ－ＭＰ的平均回收率为７４．４１％，Ｒ－ＭＰ的平均回收率为７３．７８％。并以ＭＰ为探针药物，对３２名志愿者的尿样进行了ＭＰ氧化代谢分型研究。     

Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications

Two fluorescent "off-on" probes YYH1 and YYH2 were used for bioimaging mitochondrial polarity and viscosity.     

Synthesis of Tetra—Schiff Base Macrocyclic Compound Containing Benzo—12—crown—4

Tetra-Schiff base macrocyclic compound containing benzo-12-crown-4 was synthesized via condensation of 2,6-diformyl-4-methyl-phenol with 4′，5′-diaminobenzo-12-C-4 promoted by proton. The compound was characterized by MS,IR ^1HNMR spectroscopy and elemental analysis.