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41.
Berisio R Granata V Vitagliano L Zagari A 《Journal of the American Chemical Society》2004,126(37):11402-11403
The analysis of factors contributing to the stability of proteins is a subject of intense debate. Particularly challenging is the study of structural proteins, since their function is their structure. Among these is collagen, the key structural component of bones, skin, cartilage, tendons, and other connecting tissues. It is well established that the collagen triple helix is characterized by the presence of hydroxyproline, whose content modulates triple helix thermal stability according to the requirement of the host organism. Because of the complexity and the fibrous nature of collagen, data on the stability and structure of this protein have been mainly obtained by the use of collagen-like polypeptides. On the basis of CD characterization of collagen-like polypeptides we here show that the presence of Hyp at the X position of repeating triplets Hyp-Hyp-Gly stabilizes the triple helix significantly. This extra-stabilization has been ascribed, by using molecular modeling, to the formation of a hydrogen bond between Hyp residues belonging to the X and the Y positions of adjacent chains. This communication also provides a comprehensive interpretation of the ensemble of available data on polypeptides containing proline derivatives. 相似文献
42.
Examples of various chemical reactions occurring in the matrix or in the selvedge region in fast atom bombardment (FAB) mass spectrometry are discussed. These are categorized as oxidations and reductions; substitutions; clusterings and additions; and sample decomposition or transformation. Some reactions observed showed significant time behaviour and in one case it was possible to determine rate constants. These data suggest that chemical reactions can be accelerated significantly by fast atom bombardment. 相似文献
43.
Haas P Hempstead M Jensen T Kagan H Kass R Behrends S Gentile T Guida JM Guida JA Morrow F Poling R Rosenfeld C Thorndike EH Tipton P Besson D Green J Namjoshi R Sannes F Skubic P Stone R Bortoletto D Chen A Goldberg M Horwitz N Jawahery A Lubrano P Moneti GC Trahern CG van Hecke H Csorna SE Garren L Mestayer MD Panvini RS Word GB Yi X Alam MS Bean A Ferguson T Avery P Bebek C Berkelman K Blucher E Cassel DG Copie T DeSalvo R DeWire JW Ehrlich R Galik RS Gilchriese MG Gittelman B Gray SW 《Physical review letters》1985,55(12):1248-1251
44.
The interpretation of the infrared active fundamentals of TCNQ and chloranil monovalent anions is given for the first time. The rationalization of the infrared spectra was made possible by the recently achieved vibrational assignment of the corresponding neutral molecules and is mainly based on a set of judicious adjustments of their empirical valence force fields. 相似文献
45.
Nardi L 《Journal of chromatography. A》2003,985(1-2):39-45
Partition coefficients of benzene, toluene, ethylbenzene and xylenes (BTEX), between crosslinked polydimethylsiloxane and water, were determined at room temperature by capillary extraction (a form of in-tube solid-phase microextraction, SPME) coupled to open tubular gas chromatography (in-tube SPME-high-resolution GC). A series of 7-9 repetitive extractions, performed on a 1-ml volume of diluted aqueous BTEX sample by the double-syringe squeeze method, gave exponential regression curves which fit very well with those predicted by partition theory. From the equations of the curves of relative FID response vs. extraction number, experimental Kd were easily calculated and the results compared with literature values. The whole measurement requires about 1 h from the start of the experiment to the final calculation of all BTEX partition coefficients. In-tube SPME resulted in a fast, clean, efficient, and cheaper alternative than the classic 1-cm, externally coated, SPME fiber-holder technique. 相似文献
46.
[structure: see text] An approach relying on quantum mechanical calculations of proton-proton and proton-carbon J coupling values is proposed as a tool for assigning the relative configuration on chiral organic compounds. The method is suitable for carbon frameworks containing several adjacent stereogenic centers and may allow significant advances in the extensive use of spin-spin couplings in structural elucidation. 相似文献
47.
Cametti M Nissinen M Dalla Cort A Mandolini L Rissanen K 《Chemical communications (Cambridge, England)》2003,(19):2420-2421
Uranyl-salophen complexes endowed with aromatic side arms behave as very efficient ditopic receptors towards tetralkylammonium halides as a result of a combination of Lewis acid-base and cation-pi interactions. 相似文献
48.
One hundred and one volatile compounds, reported in literature as powerful odorants of wine, were quantified by Gas Chromatography-Selective Ion Monitoring/Mass Spectrometry (GC-SIM/MS) in Primitivo, Aglianico, Merlot and Cabernet Sauvignon red wines. Wine samples were extracted by 3 different extraction methods: 1) separation of the alcoholic fraction from the aqueous phase by salting-out and subsequent extraction by liquid-liquid micro-extraction with 1,1,2-trichlorotrifluoroethane (Freon 113); 2) extraction by liquid-liquid micro-extraction with dichloromethane; 3) solid phase extraction (SPE cartridge: 800 mg of LiChrolut EN resin) with pentane-dichloromethane (20:1) and dichloromethane. The selection of the ion fragments used for quantification was directly performed on a red wine sample. For each compound the area of the corresponding peak was normalized respect to the peak of the internal standard and then interpolated in a calibration curve obtained analysing a model wine solution (water, ethanol, tartaric acid and known amounts of analytes and of internal standard). The methods showed a good linearity: r2>0.990, except for farnesol (isomer a and c), octanal, decanal, furaneol and phenylacetic acid with 0.966 < or = r2 < or = 0.990. The 7 most powerful odorants were: beta-damascenone, acetaldehyde, maltol, ethyl 2-methylbutanoate, ethyl 3-methylbutanoate, 3-methylbutanoic acid and acetal; 7 other slightly less important were: ethyl hexanoate, ethyl acetate, 1-octen-3-ol, butanoic acid, rose oxide, furaneol and sotolon. The Aglianico wines were characterised by the major fermentation compounds (esters, fatty acids and 2-phenylethanol), beta-damascenone, beta-ionone and linalool. The Primitivo wines were characterized by furaneol, methoxypyrazine, gamma-nonalactone and acetaldehyde, while Cabernet Sauvignon and Merlot wines principally by cask derivates (vanillin, (Z) 3-methyl-gamma-octalactone [(Z) wiskylactone], maltol and eugenol), some aldehydes and 3-isopropyl-2-methoxypyrazine. 相似文献
49.
Andreas Stockhammer Klaus-Hermann Dahmen Tobias Gerfin Luigi M. Venanzi Volker Gramlich Walter Fetter 《Helvetica chimica acta》1991,74(5):989-992
The cluster compounds [Pt3(μ-CO)3(PR3)3] act as Lewis bases towards the metal halides of Group XI, MX, Group XII, MX2, and Group XIII, MX3, to form cluster compounds of the composition [{MXn}{Pt3(μ-CO)3(PR3)3}]. The X-ray crystal structure, NMR and IR data are given for the compound [{ZnI}{Pt3(μ-CO)3(PPh(i-Pr)2)3}]. 相似文献
50.
[graphs: see text] QM GIAO calculations of 13C and 1H chemical shift values of the ArCH2Ar group have been performed, using the hybrid DFT functional MPW1PW91 and the 6-31G(d,p) basis set, on some representative calixarenes and on a series of simplified calixarene models allowing derivation of chemical shift surfaces versus phi and chi dihedral angles. A good reproduction of experimental data was obtained. The applicability of chemical shift surfaces in the study of calixarene conformational features is illustrated. 相似文献