New approach to chemical modification of PIM-1 for gas separation membranes

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Monitoring Methylmalonic Aciduria by NMR Urinomics

The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.     

The novel structural modification of pyridoxal via its cyclization into 2-acyl- and 2-heteroarylfuro[2,3-c]pyridines

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A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms

A new route to synthesize cyclophellitol and epi-cyclophellitol from racemic starting materials in enantiopure forms has been developed. The synthesis involves a multi-enzymatic biotransformation pathway of the novel cyano-cyclitol (1R,4S,5R,6R)/(1S,4R,5S,6S)-4,5,6-trihydroxycyclohex-2-enecarbonitrile by a cooperative use of lipase, nitrile hydratase, and amidase.     

Nitroguanyl azide

Crystals of the title compound, nitro­carbam­imidoyl azide, CH₂N₆O₂, consist of two symmetry‐independent mol­ecules and the structure is stabilized by intra‐ and intermolecular hydrogen bonds. The mol­ecule possesses a nitr­imine structure.     

On grid generation for numerical models of geophysical fluid dynamics

A simple geometric condition that defines the class of classical (stereographic, conic and cylindrical) conformal mappings from a sphere onto a plane is derived. The problem of optimization of computational grid for spherical domains is solved in an entire class of conformal mappings on spherical (geodesic) disk. The characteristics of computational grids of classical mappings are compared for different spherical radii of geodesic disk. For a rectangular computational domain, the optimization problem is solved in the class of classical mappings and respective area of the spherical domain is evaluated.     

Microwave‐assisted derivatization of cellulose in an ionic liquid: An efficient,expedient synthesis of simple and mixed carboxylic esters

Microwave (MW)‐assisted cellulose dissolution in ionic liquids (ILs) has routinely led either to incomplete biopolymer solubilization, or its degradation. We show that these problems can be avoided by use of low‐energy MW heating, coupled with efficient stirring. Dissolution of microcrystalline cellulose in the IL 1‐allyl‐3‐methylimidazolium chloride has been achieved without changing its degree of polymerization; regenerated cellulose showed pronounced changes in its index of crystallinity, surface area, and morphology. MW‐assisted functionalization of MCC by ethanoic, propanoic, butanoic, pentanoic, and hexanoic anhydrides has been studied. Compared with conventional heating, MW irradiation has resulted in considerable decrease in dissolution and reaction times. The value of the degree of substitution (DS) was found to be DS_ethanoate > DS_propanoate > DS_butanoate. The values of DS_pentanoate and DS_hexanoate were found to be slightly higher than DS_ethanoate. This surprising dependence on the chain length of the acylating agent has been reported before, but not rationalized. On the basis of the rate constants and activation parameters of the hydrolysis of ethanoic, butanoic, and hexanoic anhydrides in aqueous acetonitrile (a model acyl transfer reaction), we suggest that this result may be attributed to the balance between two opposing effects, namely, steric crowding and (cooperative) hydrophobic interactions between the anhydride and the cellulosic surface, whose lipophilicity has increased, due to its partial acylation. Four ethanoate‐based mixed esters were synthesized by the reaction with a mixture of the two anhydrides; the ethanoate moiety predominated in all products. The DS is reproducible and the IL is easily recycled. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 48: 134–143, 2010