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Cardoso Daisy Alves Valle Eliana Maíra Agostini Codognoto Lucia 《Journal of Solid State Electrochemistry》2018,22(5):1549-1555
Journal of Solid State Electrochemistry - In this work, the interaction of the pesticide methyl parathion (MP) with the lead metal ion was evaluated using a carbon electrode reused from a zinc... 相似文献
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Francesca Bettazzi Ezat Hamid-Asl Carla Lucia Esposito Cristina Quintavalle Nello Formisano Serena Laschi Silvia Catuogno Margherita Iaboni Giovanna Marrazza Marco Mascini Laura Cerchia Vittorio De Franciscis Gerolama Condorelli Ilaria Palchetti 《Analytical and bioanalytical chemistry》2013,405(2-3):1025-1034
MicroRNAs (miRNAs, miRs) are naturally occurring small RNAs (approximately 22 nucleotides in length) that have critical functions in a variety of biological processes, including tumorigenesis. They are an important target for detection technology for future medical diagnostics. In this paper we report an electrochemical method for miRNA detection based on paramagnetic beads and enzyme amplification. In particular, miR 222 was chosen as model sequence, because of its involvement in brain, lung, and liver cancers. The proposed bioassay is based on biotinylated DNA capture probes immobilized on streptavidin-coated paramagnetic beads. Total RNA was extracted from the cell sample, enriched for small RNA, biotinylated, and then hybridized with the capture probe on the beads. The beads were then incubated with streptavidin–alkaline phosphatase and exposed to the appropriate enzymatic substrate. The product of the enzymatic reaction was electrochemically monitored. The assay was finally tested with a compact microfluidic device which enables multiplexed analysis of eight different samples with a detection limit of 7 pmol L?1 and RSD?=?15 %. RNA samples from non-small-cell lung cancer and glioblastoma cell lines were also analyzed. 相似文献
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Adina I. Ciuciu Dr. Lucia Flamigni Dr. Roman Voloshchuk Prof. Dr. Daniel T. Gryko 《化学:亚洲杂志》2013,8(5):1004-1014
An assembly consisting of three units, that is, a meso‐substituted corrole ( C3 ), 1,8 naphthaleneimide ( NIE ), and a Zn porphyrin ( ZnP ), has been synthesized. NIE is connected to C3 through a 1,3‐phenylene bridge and to the ZnP unit through a direct C? C bond. The convergent synthetic strategy includes the preparation of a trans‐A2B‐corrole possessing the imide unit, followed by Sonogashira coupling with a meso‐substituted A3B‐porphyrin. The photophysical processes in the resulting triad ZnP-NIE-C3 are examined and compared with those of the corresponding C3-NIE dyad and the constituent reference models C3 , NIE , and ZnP . Excitation of the NIE unit in C3-NIE leads to a fast energy transfer of 98 % efficiency to C3 with a rate ken=7.5×1010 s?1, whereas excitation of the corrole unit leads to a reactivity of the excited state identical to that of the model C3 , with a deactivation rate to the ground state k=2.5×108 s?1. Energy transfer to C3 and to ZnP moieties follows excitation of NIE in the triad ZnP-NIE-C3 . The rates are ken=7.5×1010 s?1 and ken=2.5×1010 s?1 for the sensitization of the C3 and ZnP unit, respectively. The light energy transferred from NIE to Zn porphyrin unit is ultimately funneled to the corrole component, which is the final recipient of the excitation energy absorbed by the different components of the array. The latter process occurs with a rate ken=3.4×109 s?1 and 89 % efficiency. Energy transfer processes take place in all cases by a Förster (dipole–dipole) mechanism. The theory predicts quite satisfactorily the rate for the ZnP/C3 couple, where components are separated by about 23 Å, but results in calculated rates that are one to two orders of magnitude higher for the couples NIE/ZnP (D/A) and NIE/C3, which are separated by distances of about 14 and 10 Å, respectively. 相似文献
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Roberta Del Sole Anna Scardino Maria Rosaria Lazzoi Lucia Mergola Sonia Scorrano Giuseppe Vasapollo 《Mikrochimica acta》2013,180(15-16):1401-1409
A molecularly imprinted polymer (MIP) for the specific retention of neopterin has been developed. A set of 6 polymers was prepared by radical polymerization under different experimental condition using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinker, with the aim to understand their influence on the efficiency of the MIP. The performance of each MIP was tested in batch experiments via their binding capacity. The MIP prepared in the presence of nickel ions in dimethylsulfoxide-acetonitrile mixture (P4) exhibited the highest binding capacity for neopterin (260 μmol per gram of polymer). A selectivity study with two other pteridines demonstrated the polymer P4 also to possess the best selectivity. Figure
A molecularly imprinted polymer for the specific retention of neopterin was developed. A set of 6 polymers was prepared under different experimental condition. The performance of each MIP was tested through their binding capacity. The MIP P4 prepared in the presence of nickel ions exhibited the highest binding capacity 相似文献
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A method for C-Br/C-H bis-phenylation of methyl 4-bromocrotonate via nickel-catalyzed cross-coupling reaction has been developed. This protocol involves commercially available catalyst components and furnishes a suitable doubly phenylated building block. 相似文献
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Andrea Ventrella Raffaella Verrone Francesco Longobardi Angela Agostiano Vincenzo Lippolis Michelangelo Pascale Chris M. Maragos Michael Appell Lucia Catucci 《Journal of inclusion phenomena and macrocyclic chemistry》2013,75(3-4):285-292
T-2 and HT-2 toxins are mycotoxins produced by several Fusarium species that are commonly found in various cereal grains, including oats, barley, wheat and maize. Intake estimates indicate that the presence of these mycotoxins in the diet can be of concern for public health. In this work, the inclusion processes occurring between fluorescent anthracene-derivatives of T-2 and HT-2 toxins and different cyclodextrin (CD) molecules were investigated in aqueous solutions by means of UV–Vis absorption, fluorescence emission and dynamic light scattering. Binding constant values and chemico-physical parameters were calculated. It was found that β-CDs give stronger inclusion reactions with both T-2 and HT-2 derivatives, as stated by important emission intensity increments. Such interactions were found to be fundamentally enthalpy-driven. Among β-CDs, the effect of the methylation at hydroxyl groups was tested: as a result, the di-methyl form of β-CD was found to induce the best fluorescence intensity enhancements. 相似文献