Nanodiamonds: A Cutting-Edge Approach to Enhancing Biomedical Therapies and Diagnostics in Biosensing

Nanodiamonds (NDs) have garnered attention in the field of nanomedicine due to their unique properties. This review offers a comprehensive overview of NDs synthesis methods, properties, and their uses in biomedical applications. Various synthesis techniques, such as detonation, high-pressure, high-temperature, and chemical vapor deposition, offer distinct advantages in tailoring NDs′ size, shape, and surface properties. Surface modification methods further enhance NDs′ biocompatibility and enable the attachment of bioactive molecules, expanding their applicability in biological systems. NDs serve as promising nanocarriers for drug delivery, showcasing biocompatibility and the ability to encapsulate therapeutic agents for targeted delivery. Additionally, NDs demonstrate potential in cancer treatment through hyperthermic therapy and vaccine enhancement for improved immune responses. Functionalization of NDs facilitates their utilization in biosensors for sensitive biomolecule detection, aiding in precise diagnostics and rapid detection of infectious diseases. This review underscores the multifaceted role of NDs in advancing biomedical applications. By synthesizing NDs through various methods and modifying their surfaces, researchers can tailor their properties for specific biomedical needs. The ability of NDs to serve as efficient drug delivery vehicles holds promise for targeted therapy, while their applications in hyperthermic therapy and vaccine enhancement offer innovative approaches to cancer treatment and immunization. Furthermore, the integration of NDs into biosensors enhances diagnostic capabilities, enabling rapid and sensitive detection of biomolecules and infectious diseases. Overall, the diverse functionalities of NDs underscore their potential as valuable tools in nanomedicine, paving the way for advancements in healthcare and biotechnology.     

Microdetermination of molybdenum in organometallic compounds by molecular emission and atomic absorption spectrometry

A direct method is described for the determination of molybdenum in mg amounts of organomolybdenum compounds by flame emission or atomic absorption spectrometry. Air/acetylene, air/hydrogen and dinitrogen oxide/acetylene flames were used. The emission of molybdenum oxide is found to be analytically useful in the hydrogen-based flames while the acetylene-based flames are better for atomic absorption. Various organomolybdenum compounds were analysed by both methods as well as by an alternative spectrophotometric method, with satisfactory agreement. The procedure involves simply dissolving the sample in a mixed solvent and aspirating the solution into the flame.     

Thermal analysis of phase change emulsion

This paper presents some results obtained by Differential Scanning Calorimetry (DSC) for characterizing the phase transition within an emulsion. The dispersed substances are either hexadecane, octadecane, water or binary solution. A non-equilibrium model taking into account the inter-phase heat transfer between the emulsifying medium and the dispersed droplet is proposed and explains the main experimental features.     

Chromogenic and fluorogenic detection of copper ions in the solution and intracellular media

The development of a fluorescent sensor for the trace detection of the metallic contamination in the ecosystem and biological media have been a demand to reduce the health risk and environmental protection. Herein, we report the synthesis of 2‐formyl‐5‐picolinyl‐substituted rhodamine B derivative through Schiff base formation for the trace detection of the copper ions in the aqueous organic media as well as inside the live cells via bioimaging experiments. The ligand was successfully employed to detect the minute copper level ratiometrically through the chromogenic and fluorogenic response. The detection limit of the sensor was found to be 0.54 × 10^?9 mol/L using 3 σ/slope relations. The reversible behavior of the ligand copper complex was determined using sulfide ions that regenerate the entire native properties of the ligands by snatching copper from the complex. The bioimaging experimental results represent the efficient membrane permeability of ligands with the minimum level of toxicity in the measured range found by the MTT assay. The appearance of bright red fluorescence from the BHK‐21 (hamster kidney fibroblast) cells upon treatment of the ligand incubated cells with the copper ions represents the utility of the proposed sensor for the copper detection probe in the intracellular media.     

Interacting Entropy-Corrected New Agegraphic K-essence, Tachyon and Dilaton Scalar Field Models in?Non-flat Universe

We consider the new agegraphic dark energy model with the help of the quantum corrections to the entropy-area relation in the setup of loop quantum gravity. Employing this new form of dark energy so called entropy-corrected new agegraphic dark energy (ECNADE), we investigate the model of interacting dark energy and derive its equation of state (EoS). We study the correspondence between the K-essence, tachyon and dilaton scalar fields with the interacting (ECNADE)in the non-flat FRW universe. Moreover, we reconstruct the corresponding scalar potentials which describe the dynamics of the scalar field.     

Interacting New Generalized Chaplygin Gas

I present a model in which dark energy interacts with matter. The former is represented by a variable equation of state. It is shown that the phantom crossing takes place at zero redshift, moreover, stable scaling solution of the Friedmann equations is obtained. I show that dark energy is most probably be either generalized phantom energy or the generalized Chaplygin gas, while phantom energy is ruled out as a dark energy candidate.     

MOCVD growth of GaN on Si(1 1 1) substrates using an ALD-grown Al2O3 interlayer

GaN thin films have been grown on Si(1 1 1) substrates using an atomic layer deposition (ALD)-grown Al₂O₃ interlayer. This thin Al₂O₃ layer reduces strain in the subsequent GaN layer, leading to lower defect densities and improved material quality compared to GaN thin films grown by the same process on bare Si. XRD ω-scans showed a full width at half maximum (FWHM) of 549 arcsec for GaN grown on bare Si and a FWHM as low as 378 arcsec for GaN grown on Si using the ALD-grown Al₂O₃ interlayer. Raman spectroscopy was used to study the strain in these films in more detail, with the shift of the E₂(high) mode showing a clear dependence of strain on Al₂O₃ interlayer thickness. This dependence of strain on Al₂O₃ thickness was also observed via the redshift of the near bandedge emission in room temperature photoluminescence (RT-PL) spectroscopy. The reduction in strain results in a significant reduction in both crack density and screw dislocation density compared to similar films grown on bare Si. Screw dislocation density of the films grown on Al₂O₃/Si substrates approaches that of typical GaN layers on sapphire. This work shows great promise for the use of oxide interlayers for growth of GaN-based LEDs on Si.     

Quantum effects on the black hole shadow and deflection angle in the presence of plasma

In this study, the optical properties of a renormalization group improved (RGI) Schwarzschild black hole (BH) are investigated in a plasma medium. Beginning with the equations of motion in a plasma medium, we aim to present the modifications in the shadow radius of the RGI BH. To this end, we compute the deflection angle of light in the weak gravity regime for uniform and non-uniform plasma media. Importantly, owing to the plasma media, we discover that the equations of motion for light obtained from the radiating and infalling/rest gas have to be modified. This, in turn, changes and modifies the expression for the intensity observed far away from the BH. Finally, we obtain the shadow images for the RGI BH for different plasma models. Although quantum effects change the background geometry, such effects are minimal, and practically detecting these effects using the current technology based on supermassive BH shadows is impossible. The parameter Ω encodes the quantum effects, and in principle, one expects such quantum effects to play significant roles only for very small BHs. However, the effects of plasma media can play an important role in the optical appearance of BHs, as they affect and modify the equations of motion.     

Crystal and molecular structure of phenylbenzyl-1-(2,2,3-trimethylcyclopropyl)phosphine oxide

The title compound crystallizes in the orthorhombic space groupPna2₁, witha=15.576(2),b=19.134(3),c=5.693(1) Å andz=4. The structure was solved by direct methods, and refined to a finalR value of 0.059. This study confirms both the structure and stereochemistry of the title compound.