Multi-mode resource-constrained project scheduling using RCPSP and SAT solvers

This paper reports on a new solution approach for the well-known multi-mode resource-constrained project scheduling problem (MRCPSP). This problem type aims at the selection of a single activity mode from a set of available modes in order to construct a precedence and a (renewable and non-renewable) resource feasible project schedule with a minimal makespan. The problem type is known to be NP-hard and has been solved using various exact as well as (meta-)heuristic procedures.The new algorithm splits the problem type into a mode assignment and a single mode project scheduling step. The mode assignment step is solved by a satisfiability (SAT) problem solver and returns a feasible mode selection to the project scheduling step. The project scheduling step is solved using an efficient meta-heuristic procedure from literature to solve the resource-constrained project scheduling problem (RCPSP). However, unlike many traditional meta-heuristic methods in literature to solve the MRCPSP, the new approach executes these two steps in one run, relying on a single priority list. Straightforward adaptations to the pure SAT solver by using pseudo boolean non-renewable resource constraints has led to a high quality solution approach in a reasonable computational time. Computational results show that the procedure can report similar or sometimes even better solutions than found by other procedures in literature, although it often requires a higher CPU time.     

Nanostructure of polysaccharide complexes

The interaction of gum arabic (GA) with chitosan (Ch) of different degree of deacetylation was studied by turbidity measurements, dynamic light scattering and atomic force microscopy. The structure of the complexes was found to be directly related to the charge density of chitosan molecules. Gum arabic and chitosan with a degree of deacetylation of 75% form soluble complexes with a loosely globular structure of about 250 nm, at weight ratios up to 1.2, if the concentrations are kept low (total biopolymer concentration up to 0.06%). If chitosan has a higher charge density (degree of deacetylation of 93%), colloidal particles are formed, independently of the polymer concentration or ratio. At low concentrations and GA/Ch ratios of 1 or 1.2, the particles have diameters of 200-250 nm. The formation of soluble complexes is attributed to a chitosan lower charge density and the presence of non-charged monomers, which prevent the efficient self-assembly of the macromolecules.     

Modelling of nano-alloying and structural evolution of bimetallic core-shell nanoparticles obtained via the microemulsion route

A Monte Carlo model has been developed to describe the formation of bimetallic nanoparticles via the microemulsion route. The motivation stems from the need to understand the kinetics of nanoparticle formation in microemulsion droplets in order to determine the best experimental conditions to synthesize a nanoparticle with a given structure. We focus our study on the influence of the homogeneous and heterogeneous critical nucleus sizes of both metals on nanoparticle structure, as well as the role played by the surfactant film flexibility. The study reveals that the final structure is sensitive to changes in the critical nucleus numbers, because these parameters determine the rate of nucleation. An increase in the difference between nucleation rates of both metals gives rise to a better segregation of metals in the final nanoparticle. Likewise, as long as the formation of heterogeneous seeds is faster, the degree of alloying is greater. Finally, a fast material intermicellar exchange leads to a better mixture of metals, so the influence of the critical nucleus sizes on nanoparticle structure becomes less pronounced as the flexibility of surfactant film is increased.     

Synthesis, antimicrobial and antiproliferative activity of novel silver(I) tris(pyrazolyl)methanesulfonate and 1,3,5-triaza-7-phosphadamantane complexes

Five new silver(I) complexes of formulas [Ag(Tpms)] (1), [Ag(Tpms)(PPh(3))] (2), [Ag(Tpms)(PCy(3))] (3), [Ag(PTA)][BF(4)] (4), and [Ag(Tpms)(PTA)] (5) {Tpms = tris(pyrazol-1-yl)methanesulfonate, PPh(3) = triphenylphosphane, PCy(3) = tricyclohexylphosphane, PTA = 1,3,5-triaza-7-phosphaadamantane} have been synthesized and fully characterized by elemental analyses, (1)H, (13)C, and (31)P NMR, electrospray ionization mass spectrometry (ESI-MS), and IR spectroscopic techniques. The single crystal X-ray diffraction study of 3 shows the Tpms ligand acting in the N(3)-facially coordinating mode, while in 2 and 5 a N(2)O-coordination is found, with the SO(3) group bonded to silver and a pendant free pyrazolyl ring. Features of the tilting in the coordinated pyrazolyl rings in these cases suggest that this inequivalence is related with the cone angles of the phosphanes. A detailed study of antimycobacterial and antiproliferative properties of all compounds has been carried out. They were screened for their in vitro antimicrobial activities against the standard strains Enterococcus faecalis (ATCC 29922), Staphylococcus aureus (ATCC 25923), Streptococcus pneumoniae (ATCC 49619), Streptococcus pyogenes (SF37), Streptococcus sanguinis (SK36), Streptococcus mutans (UA159), Escherichia coli (ATCC 25922), and the fungus Candida albicans (ATCC 24443). Complexes 1-5 have been found to display effective antimicrobial activity against the series of bacteria and fungi, and some of them are potential candidates for antiseptic or disinfectant drugs. Interaction of Ag complexes with deoxyribonucleic acid (DNA) has been studied by fluorescence spectroscopic techniques, using ethidium bromide (EB) as a fluorescence probe of DNA. The decrease in the fluorescence of DNA-EB system on addition of Ag complexes shows that the fluorescence quenching of DNA-EB complex occurs and compound 3 is particularly active. Complexes 1-5 exhibit pronounced antiproliferative activity against human malignant melanoma (A375) with an activity often higher than that of AgNO(3), which has been used as a control, following the same order of activity inhibition on DNA, i.e., 3 > 2 > 1 > 5 > AgNO(3)? 4.     

On the mechanism of the aza-Morita-Baylis-Hillman reaction: ESI-MS interception of a unique new intermediate

Solutions of aza-Morita-Baylis-Hillman (aza-MBH) reactions were directly monitored by ESI(+)-MS(/MS) spectrometry to obtain information on their mechanism. A unique bis-sulfonamide intermediate was intercepted and characterized and, based on this novel species, a mechanism that rationalizes the uniqueness of aza-MBH reactions is proposed.     

Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric

Background  

Glaucoma is a chronic neurodegenerative disease of the retina, characterized by the degeneration of axons in the optic nerve and retinal ganglion cell apoptosis. DBA/2J inbred mice develop chronic hereditary glaucoma and are an important model system to study the molecular mechanisms underlying this disease and novel therapeutic interventions designed to attenuate the loss of retinal ganglion cells. Although the genetics of this disease in these mice are well characterized, the etiology of its progression, particularly with respect to retinal degeneration, is not. We have used two separate labeling techniques, post-mortem DiI labeling of axons and ganglion cell-specific expression of the βGeo reporter gene, to evaluate the time course of optic nerve degeneration and ganglion cell loss, respectively, in aging mice.     

Operation of a 32 GHz gyrotron

The design and operation of a 32 GHz pulsed gyrotron are reported. The device is step-tuned between the TE_1,2 (24.16 GHz) and TE_0,2 (31.78 GHz) modes with cathode voltages ranging from 30 to 40kV and beam current up to 5.0A. Experimental frequencies are in close agreement with the self-consistent calculated values and in the TE_2,2 resonator mode an output peak power of 6kW corresponding to an 18% efficiency was measured by using a fast response calorimeter with a thermal sensitivity of 0.1°C/Wmin.     

Imposex and organotin body burden in the dog‐whelk (Nucella lapillus L.) along the Portuguese coast

Nucella lapillus imposex—superimposition of male characters onto prosobranch (a subclass of gastropod molluscs) females—and organotin female body burden were surveyed on the Portuguese coast, from Vila Praia de Âncora (northern limit) to Praia da Luz (southern limit), at 17 sampling stations, between May and August 2003. The vas deferens sequence index (VDSI), the relative penis size index (RPSI), the percentage of females affected with imposex (%I) and the percentage of sterile females (%S) were used to assess the level of imposex at each site. VDSI, RPSI and %I were 0.20–4.04, 0.0–42.2% and 16.7–100.0%, respectively. Sterile females were found at stations 2 (6.2%), 5 (4.0%) and 7 (5.0%). Tributyltin (TBT) and dibutyltin (DBT) female body burdens were 23–138 and <10–62 ng Sn/g dry weight, respectively. TBT female body burden was significantly correlated with RPSI and VDSI [Spearman rank order linear correlation: RPSI vs TBT body burden (b.b.) r = 0.71, p < 0.01; VDSI vs logTBT body burden r = 0.71, p < 0.01]. Imposex and TBT b.b. were highest at sites located in the proximity of harbours, where TBT leaching from antifouling paints is more intense owing to the high concentration of ships and dockyard activities. Copyright © 2005 John Wiley & Sons, Ltd.     

Resonance in open coaxial cylindrical resonators

A study of the electrodynamical properties of open coaxial cylindrical resonators using a partially conical inner rod is made along with experimental verification. On the basis of a geometrical criterion for the occurrence of high-Q resonances, it turns out to be possible to discriminate certain classes of TE modes by keeping to a minimum value their diffrationQ factors. In particular, for an especially designed cavity only TE_0.2 and TE_1.3 modes appear to have strong resonance in the 6 · 14GH _z range as a result of the action of the coaxial insert.     

Rubber network in elastomer nanocomposites

The influence of inorganic nanoparticles on crosslinking mechanism of elastomers has been evaluated by applying the tube model on equilibrium statistical mechanics. The results have shown that a highly ordered structure with a huge amount of entanglements, wherein the polymer is nanoscopically confined, is formed by the addition of nanoparticles. These physical links exhibit freedom of movement under stretching, but in a lower volume because of confinement. That is, network molecular parameters such as lateral tube dimensions or average molecular mass of the chains decreased in presence of nanoparticles.