F8BINOL, an electronically perturbed version of BINOL with remarkable configurational stability

[structure: see text] Substitution of hydrogens by fluorines at the 5, 5', 6, 6', 7, 7', 8, and 8' positions of BINOL strongly affects distribution of electron density within the biaryl skeleton but has a very small influence on the torsion angle. The most important consequence of this structural alteration is the dramatic increase in configurational stability of homochiral F8BINOL.     

Use of ion mobility mass spectrometry and a collision cross‐section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide

We report the development of an enhanced algorithm for the calculation of collision cross‐sections in combination with Travelling‐Wave ion mobility mass spectrometry technology and its optimisation and evaluation through the analysis of an organoruthenium anticancer complex [(η⁶‐biphenyl)Ru^II(en)Cl]⁺. Excellent agreement was obtained between the experimentally determined and theoretically determined collision cross‐sections of the complex and its major product ion formed via collision‐induced dissociation. Collision cross‐sections were also experimentally determined for adducts of this ruthenium complex with the single‐stranded oligonucleotide hexamer d(CACGTG). Ion mobility tandem mass spectrometry measurements have allowed the binding sites for ruthenium on the oligonucleotide to be determined. Copyright © 2009 John Wiley & Sons, Ltd.     

Potassium N‐(6‐oxo­cyclo­hexa‐1,3‐dien‐5‐yl­idene­methyl)­glycinate

We are very interested in characterizing ligands derived from salicyl­aldehyde and α‐amino acids. These ligands form interesting complexes with different transition metals, which are very useful for understanding some biological systems. For Schiff bases derived from salicyl­aldehyde and different alkyl­amines or aryl­amines, the enol–imine form is predominant. The title compound, (I), shows bond distances which are clearly in agreement with the keto–amine form.     

A hydrogen-bonded adduct containing seven-component supramolecular aggregates

The title compound is a salt, 3,6,9,16,19,22-hexaaza­tri­cyclo­[22.2.2.2^11,14]­triaconta-1(26),11(29),12,14(30),24,27-hexa­ene–3,5-di­nitro­benzoic acid–methanol (1/4/2), C₂₄H₄₂N₆⁴⁺·4C₇H₃N₂O₆⁻·2CH₄O, in which the cation lies across a centre of inversion and one of the two independent anions is positionally disordered over two sets of atom sites having equal occupancy. The components are linked by four types of N—H⃛O hydrogen bond [N⃛O 2.674 (2)–2.815 (2) Å; N—H⃛O 149–163°] and one type of O—H⃛O hydrogen bond in which the acceptor is disordered over two closely adjacent sites [O⃛O 2.67 (4) and 2.75 (4) Å; O—H⃛O 172 and 173°], forming centrosymmetric seven-component aggregates.