Search for neutrino-produced magnetic monopoles in a bubble chamber exposure

J. Schwinger has suggested that magnetically charged particles could be produced via a magnetically charged intermediate boson process similar to the mechanism sometimes envisioned for double muon production by neutrinos. A search for magnetic monopole production by neutrinos has been made by reexamining the CERN heavy liquid bubble chamber pictures obtained during the neutrino exposures of 1963 and 1967. Five different searches were made for events which contained a free monopole with and without target nucleus excitation, and for bound monopoles which deexcited by photon emission. No events were found. Neutrino monopole production cross-section limits are given.     

Fused-s-triazino heterocycles. XII. 13H-4,6,7,8,13a, 13c-hexaazabenzo-[de]naphthacene,a new ring system

The synthesis of the titled compound is described using 5-(2-carboxyanilino)-2-methyl-1,3-4,6,9b-pentaaza-phenalene as starting material.     

A generalization of the schwarz alternating method to an arbitrary number of subdomains

Summary We give a generalization of the Schwarz alternating method to an arbitrary number of subdomains. As applications, we prove that the method converges for the main second-order boundary value problems, as well as for the system of linear elasticity.For the Dirichlet problems it is proved that the method converges geometrically and some numerical examples are given.     

On a Fourier Method of Embedding Domains Using an Optimal Distributed Control

We propose a domain embedding method to solve second order elliptic problems in arbitrary two-dimensional domains. This method can be easily extended to three-dimensional problems. The method is based on formulating the problem as an optimal distributed control problem inside a rectangle in which the arbitrary domain is embedded. A periodic solution of the equation under consideration is constructed easily by making use of Fourier series. Numerical results obtained for Dirichlet problems are presented. The numerical tests show a high accuracy of the proposed algorithm and the computed solutions are in very good agreement with the exact solutions.     

A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations

The parent 5H-indazolo[3,2-b]benzo[d]-1,3-oxazine heterocycle as well as a series of novel analogues have been synthesized utilizing two subsequent intramolecular heterocyclizations in one pot. A variety of diversity groups were added to explore the scope of this reaction and to provide a number of new compounds for biological screening.     

Total synthesis of leucascandrolide a: a new application of the Mukaiyama aldol-Prins reaction

A total synthesis of the marine natural product leucascandrolide A has been completed. The titanium tetrabromide-mediated Mukaiyama aldol-Prins (MAP) reaction with aldehydes developed in our group provided a highly convergent and stereoselective method for assembling the core of the molecule. A new class of MAP reactions with acetals is introduced, and mechanistic considerations for both MAP methods are described. The total synthesis was completed by coupling of the side chain through two avenues: a known Still-Gennari olefination and a new Z-selective aldol/dehydroselenation reaction. Both procedures were highly selective and provided the natural product.     

Optical molecular fluorescence determination of ultra-trace beryllium in occupational and environmental samples using highly alkaline conditions

Exposures to beryllium (Be), even at extremely low levels, can cause severe health effects in a percentage of those exposed; consequently, occupational exposure limits (OELs) promulgated for this element are the lowest established for any element. This work describes the advantages of using highly alkaline dye solutions for determination of Be in occupational hygiene and environmental samples by means of an optical molecular fluorescence technique after sample extraction in 1–3% (w?w^?1) aqueous ammonium bifluoride (NH₄HF₂). Improved attributes include the ability to further enhance the detection limits of Be in extraction solutions of high acidity with minimal dilution, which is particularly beneficial when NH₄HF₂ solutions of higher concentration are used for extraction of Be from soil samples. Significant improvements in Be method detection limits (MDLs) are obtained at levels manyfold below those reported previously for this methodology. Notably, MDLs for Be of <0.01 ng L^?1 /0.1 ng per sample have been attained, which are superior to MDLs routinely reported for this element by means of the most widely used ultra-trace elemental measurement technique, inductively coupled plasma mass spectrometry (ICP-MS). Very low MDLs for Be are essential in consideration of reductions in OELs for this element in workplace air by health organisations and regulatory agencies in the USA and internationally. Applications of enhanced Be measurements to air filter samples, surface wipe samples, soils and newly designed occupational air sampler inserts are illustrated.     

A simple non-invasive method to detect and monitor hypercapnia: the sodium [13C]bicarbonate breath test

Arterial partial pressure of carbon dioxide (paCO(2)) is commonly evaluated by an invasive test, the arterial blood gas analysis (ABG). The sodium [(13)C]bicarbonate breath test (SBT) can potentially estimate arterial paCO(2). We studied 55 subjects with respiratory disorders and performed the ABG and the SBT to determine if the SBT can predict hypercapnia. The percentage of (13)CO(2) recovered in exhaled breath at 30 minutes (PDR(30)) alone was able to discriminate clinically significant hypercapnia (>53 mmHg) with a sensitivity of 82 % and specificity of 93 % (p<0.001). To evaluate the clinical utility of the SBT as a non-invasive substitute to repeated ABG, we monitored the progress of seven chronic obstructive pulmonary disease (COPD) patients on therapy with both the ABG and the SBT. The PDR(30) values from the SBT were able to correctly predict improvement or worsening of paCO(2) with 100 % accuracy. In conclusion, the SBT is a simple test that can be used in clinical practice to detect clinically significant hypercapnia and monitor COPD patients before and after therapy.