Manipulating Host-Guest Charge Transfer of a Water-Soluble Double-Cavity Cyclophane for NIR-II Photothermal Therapy

Water-soluble small organic photothermal agents (PTAs) over NIR-II biowindow (1000–1350 nm) are highly desirable, but the rarity greatly limits their applications. Based on a water-soluble double-cavity cyclophane GBox-4⁴⁺ , we report a class of host–guest charge transfer (CT) complexes as structurally uniform PTAs for NIR-II photothermal therapy. As a result of its high electron-deficiency, GBox-4⁴⁺ can bind different electron-rich planar guests with a 1 : 2 host/guest stoichiometry to readily tune the CT absorption band that extends to the NIR-II region. When using a diaminofluorene guest substituted with an oligoethylene glycol chain, the host–guest system realized both good biocompatibility and enhanced photothermal conversion at 1064 nm, and was then exploited as a high-efficiency NIR-II PTA for cancer cell and bacterial ablation. This work broadens the potential applications of host–guest cyclophane systems and provides a new access to bio-friendly NIR-II photoabsorbers with well-defined structures.     

Osmium Redox Hydrogel Mediated Biosensor for Measurement of Low Concentration Glucose Extracted by Reverse Iontophoresis

An osmium redox hydrogel mediated biosensor for continuous monitoring of glucose extracted from subcutaneous solution by reverse iontophoresis has been developed. For the measurement of low concentration glucose, osmium‐poly(vinylpyridine) wiring horseradish peroxidase was introduced to modify the smooth Au electrodes, and the developed glucose biosensor exhibited a high sensitivity of 11.45 nA μM^?1 cm^?2 and a low detection limit of 2 μM, as well as a high operational stability of more than 97% of its initial activity over a test period of 13.5 h in stirred glucose solution at low applied potential (?0.1 V vs. Ag|AgCl), efficiently inhibiting the electroactive interferences. Permeability of the hydrogels was studied and a diffusion coefficient of 2.4×10^?5 cm²/s for H₂O₂ was obtained. In addition, the effects, such as temperature and the variation happening on Ag|AgCl counter electrode, on determination of glucose were also considered. The proof‐of‐feasibility of the biosensors for the monitoring of the glucose extracted from the subcutaneous solution was tested in vitro, and the responses of the sensors were analyzed. A linear response to current produced by extracted glucose in the concentration range of subcutaneous glucose from 1.0 to 12 mM was obtained with a correlation coefficient up to 0.989. These results testify the feasibility of the developed sensors for measuring the low concentration glucose and have significance for the development of noninvasive glucose monitoring system for the control of diabetes.     

Ag-deposited hollow mesoporous silica microspheres for rapid decolorizing of dye pollutants

Research on Chemical Intermediates - In this paper, we demonstrate a facile electroless plating method for fabricating silver nanoparticles deposited onto hollow mesoporous silica microspheres...     

Determination of apramycin in animal feeds by solid-phase extraction and liquid chromatography with precolumn derivatization and fluorescence detection

A high-performance liquid chromatographic method for determining apramycin in animal feeds was developed. Apramycin in feeds was extracted with 0.1 M HCl solution and cleaned up with an MCX solid-phase extraction column. The purified extract was derivatized with o-phthaldehyde, and components were separated on a C18 column and detected with a fluorescence detector. Mass spectrometric data confirmed that apramycin was derivatized at all the 4 primary amines on the apramycin molecule. Average recoveries at 8 included levels (5, 10, 20, 40, 80, 200, 400, and 2000 mg/kg) ranged from 92.2 to 100.5%, and the coefficients of variation were < 6.5%. Standard curves were linear over the range 0.05 to 10 microg/mL. The detection and quantitation limits were determined to be 0.2 and 1.0 mg/kg, respectively.     

Ytterbium(II) complex bearing a diaminobis(phenolate) ligand: synthesis, structure, and one-electron-transfer and epsilon-caprolactone polymerization reactions

The first divalent ytterbium complex supported by a diaminobis(phenolate) ligand, YbL(THF)2.0.5C7H8 (1; THF = tetrahydrofuran), was synthesized in good yield by the amine elimination reaction of Yb[N(SiMe3)2]2(THF)2 with H2L (L = [Me2NCH2CH2N(CH2-2-OC6H2-3,5-But2)2]) in a 1:1 molar ratio. X-ray structural determination shows complex 1 to be a THF-solvated monomer, which adopts a distorted octahedral coordination geometry around the Yb atom. Complex 1 can react with PhNCO and PhCCH, as a single electron-transfer reagent, to give the corresponding reduction coupling product [(YbLOCNPh)(THF)]2.4THF (2) and the alkynide complex YbLCCPh(DME) (3; DME = 1,2-dimethoxyethane). Complexes 2 and 3 have been characterized by X-ray crystal structural analysis. In complex 2, the dianionic oxamide ligand resulting from the reductive coupling of two phenyl isocyanate molecules coordinates to two Yb atoms in a mu,eta4 fashion. Complex 3 has a monomeric structure with a Yb-C(terminal phenylacetynide) bond length of 2.374(3) A. Complex 1 is also a highly efficient catalyst for ring-opening polymerization of epsilon-caprolactone.     

2,6-二甲酚双波长分光光度法同时测定水中NO3-及NO2-的研究

水中NO₃^-和NO₂^-的一般光度法同时测定已见报导,但其操作手续均较麻烦。2,6-二甲酚光度法单独测定NO₂^-或NO₂^-虽已有报导,可是它们相互干扰。我们采用双波长光度法,测定NO₃^-和NO₂^-在H₂SO₄介质与2,6-二甲酚的反应产物,既免除了它们的相互干扰,又达到同时测定的目的。     

铜(Ⅱ)-新铜试剂-谷胱甘肽-乙醇体系显色反应研究

本文研究铜（Ⅱ）－新铜试剂－谷胱甘肽－乙醇体系的显色反应,探讨了反应条件。试验中发现乙醇可以使吸光度增加１３．８％,提高提高了显色反应的灵敏度。该方法用于测定大豆提取液中谷胱甘肽的含量,取得了满意结果。     

胶体光子晶体膜的超浸润性研究进展

近年来,由于具有特殊浸润性的胶体光子晶体膜在传感、检测、催化等方面的重要应用,胶体光子晶体膜的超浸润研究受到科研工作者的广泛关注.本文阐述了包括超亲液、超疏液、两亲性、梯度浸润性、可调控浸润性、图案浸润性等具有特殊浸润性光子晶体膜的制备及其相关应用,并讨论疏水、超疏水和亲-疏图案不同浸润性基底对所制备胶体光子晶体膜的功能性及其相关应用的影响.该工作对于发展新型功能型材料器件的制备具有重要的借鉴及指导意义.     

Color‐Oscillating Photonic Crystal Hydrogel

In this work, a color‐oscillating system is first developed by combining the intrinsic peristaltic motion of a Landolt pH‐oscillator with the structure color of a well‐designed pH‐sensitive photonic crystal hydrogel. As a result, the pH oscillation reaction procedure could be distinctly monitored by the distinct change of structure color/optic signal. The oscillation rhythm of the pH well coincides with that of the stopband/structure color. The oscillation detail of each cycle can also be clearly monitored by color change. This work would be of great significance for the promising applications of real‐time monitoring of the microactuator by optical signal or structure color.