Characterization, synthesis and self-aggregation of (-)-alternarlactam: a new fungal cytotoxin with cyclopentenone and isoquinolinone scaffolds

(-)-Alternarlactam [(-)-1], a new promising cytotoxin against two human cancer cell lines, was isolated from an endophyte culture and synthesized (along with (+)-1) from readily available starting materials. The absolute configuration, chirality-activity relevance and self-aggregation of (-)-1 were assigned by a combination of synthetic, spectroscopic and computational approaches. The full characterization of the new fungal cytotoxin may provide valuable information in the discovery of new antitumor agents.     

VIM3 Corrigendum available online

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VIM3 Corrigendum available online     

Fe-MILs系可见光响应复合材料在光诱导反应中的应用研究进展

能源危机和环境问题已成为人类社会面临和亟待解决的两个重大问题。光催化技术被认为是解决能源危机和环境问题有效方法之一。来瓦希尔骨架材料（MILs）是一类著名的金属骨架有机材料（MOFs）。Fe-MILs是MILs系列材料中一个重要的分支,其带隙宽度约为2.39 eV ~ 2.79 eV,能被可见光激发。然而,Fe-MILs存在光的利用率低、导电性差、光生电子-空穴复合快、光腐蚀等缺点。近年来,研究者们采用多种方法对Fe-MILs进行改性,制备了很多Fe-MILs衍生的可见光响应复合材料,并将这些材料成功用于光诱导反应。本文主要综述了近年来Fe-MILs衍生的可见光响应复合材料在水的分解、CO2还原、有机物转化、光催化固氮等多个领域的应用研究,并对Fe-MILs光催化剂的发展提出了建议。     

Analysis of ochratoxin A and ochratoxin B in traditional Chinese medicines by ultra-high-performance liquid chromatography–tandem mass spectrometry using [C20]-ochratoxin A as an internal standard

The paper reported a reliable analytical method for simultaneous determination of ochratoxin A (OTA) and ochratoxin B (OTB) in traditional Chinese medicines (TCMs) by ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). The development of the method and investigations on the matrix influence were described in particular. The matrix effects were thereby minimized by using a reliable internal standard and a simple sample pretreatment. The established method was further validated by determining the linearity (R² ≥ 0.9990), average recovery (86.3–114.2%), sensitivity (limit of quantitation 0.03–0.19 ng mL⁻¹) and precision (relative standard deviation ≤ 13.1%). It was shown to be a suitable method for simultaneous determination of OTA and OTB in various TCMs. Finally, a total of 51 TCMs widely used in China were screened for OTA and OTB with the proposed method. The results showed that only 4 samples were contaminated with ochratoxins at low levels, indicating that it was low risk of ochratoxins to consumers who occasionally used TCMs.     

基于CSP工艺铽对Q345B再结晶的影响

以CSP工艺生产的Q345热轧钢板为研究对象,采用Gleeble-1500D热模拟实验机进行单、双道次轧制模拟实验,研究了稀土铽(Tb)对Q345B钢再结晶行为的影响.结果表明,稀土铽(Tb)能够明显地推迟Q345B钢的动态再结晶,使对应峰值应力在低温轧制时提高约10%,而对980℃以上时的峰值应力影响不明显;980℃以上轧制时,稀土铽(Tb)能够明显的降低间隔时间1.5 s时的静态软化率,但随间隔时间的增加,稀土铽(Tb)对静态软化率的影响减弱;加入稀土铽能够提高完全再结晶区温度,扩大部分再结晶区.     

快速凝固结合严酷变形镁合金丝的组织与性能

采用快速凝固(RS)技术制备了厚度小于80μm,具有细微组织的Mg-6.0%Zn-1.0%Y-0.6%Ce-0.6%Zr合金薄带,薄带经往复挤压(RE)4道次后,制成Φ35 mm坯料,坯料被进一步正挤压(EX)成Φ2.08 mm~Φ1.55 mm表面光洁的细丝。用SEM和STEM分析组织,用In-stron 5500R和弯曲试验装置测试机械性能。细丝基体晶粒直径为~1μm。一类强化相颗粒的平均直径为0.25μm,另一类50 nm。变形态细丝抗拉强度和延伸率分别为335 MPa和13%;经过300℃保温10 min,然后水冷处理,抗拉强度和延伸率分别为403 MPa和12%。材料的临界弯曲直径为~6.28 mm,压应力是细丝弯曲断裂的控制因素。     

双分子水和氨气催化CF3OH分子裂解的理论研究

利用G3和CBS-QB3的理论方法研究CF₃OH分子裂解成FCFO和HF,并考虑大气中双分子和氨气对CF₃OH分子裂解的催化作用. 理论计算表明：由于在G3的理论水平下,计算的能垒为188.52 kJ/mol,所以CF₃OH分子在大气条件下不可能发生单分子裂解;当氨气和双分子水被加入时,能垒都被降到25.08 kJ/mol,起了强的催化作用. 除此之外,应用过渡态理论对速率常数进行了计算,计算结果表明：氨气催化CF₃OH分子的速率常数是单分子和双分子催化CF₃OH分子裂解速率常数的10⁹和10⁵倍. 考虑到大气中这些物质的浓度,计算结果预测了氨气催化CF₃OH分子裂解在大气中起到重要的作用.     

Aqueous Synthesis of CdTe/CdSe Core/Shell Quantum Dots as pH-Sensitive Fluorescence Probe for the Determination of Ascorbic Acid

By controlling the reflux time and the quantity of the shell materials, different sizes of thioglycollic acid (TGA) modified CdTe/CdSe core/shell quantum dots were synthesized in aqueous solution. This type of QDs was used for sensitive and selective determination of ascorbic acid in commercial tablets. Under optimal conditions, a good linearity was observed between the relative fluorescence (FL) intensity and the concentration of ascorbic acid in the range of 4.0 to 64.0 μg/mL with a correlation coefficient of 0.9968. The limit of detection was 2.4 μg/mL. This method was applied to the determination of the ascorbic acid in Vitamin C tablets and Vitamin C Yinqiao pills, and satisfactory results were obtained.     

Fractional scanned carbon dioxide laser induces collagen remodelling in murine dermis

Resurfacing using a fractional CO₂ laser shows an important promise in the therapy on photoaged skin. The present study investigated that fractional CO₂ laser with a special sequential scanned manner induced the collagen remodelling in murine dermis. The results showed that laser resulted in the improvement of elasticity and histology in the murine dermis, meaning laser efficacy depends on both of the collagen formation and organization. We further investigated the relations between skin elasticity and type I, and type III collagen. These data demonstrated that laser could significantly lead to the collagen remodelling in murine dermis and induce neocollagenisis as a mode of resurfacing.