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61.
62.
Fluorescent Coumarin–Artemisinin Conjugates as Mitochondria‐Targeting Theranostic Probes for Enhanced Anticancer Activities
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Dr. Xu Zhang Qian Ba Zhanni Gu Dr. Diliang Guo Prof. Yu Zhou Prof. Yungen Xu Prof. Hui Wang Prof. Deju Ye Prof. Hong Liu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(48):17415-17421
Mitochondria‐targeting theranostic probes that enable the simultaneously reporting of and triggering of mitochondrial dysfunctions in cancer cells are highly attractive for cancer diagnosis and therapy. Three fluorescent mitochondria‐targeting theranostic probes have been developed by linking a mitochondrial dye, coumarin‐3‐carboximide, with a widely used traditional Chinese medicine, artemisinin, to kill cancer cells. Fluorescence images showed that the designed coumarin–artemisinin conjugates localized mainly in mitochondria, leading to enhanced anticancer activities over artemisinin. High cytotoxicity against cancer cells correlated with the strong ability to accumulate in mitochondria, which could efficiently increase the intracellular reactive oxygen species level and induce cell apoptosis. This study highlights the potential of using mitochondria‐targeting fluorophores to selectively trigger and directly visualize subcellular drug delivery in living cells. 相似文献
63.
64.
Fatma Başak Aydemir Akın Günay Figen Öztoprak Ş. İlker Birbil Pınar Yolum 《Journal of Global Optimization》2013,57(2):499-519
This paper proposes the use of multiagent cooperation for solving global optimization problems through the introduction of a new multiagent environment, MANGO. The strength of the environment lays in its flexible structure based on communicating software agents that attempt to solve a problem cooperatively. This structure allows the execution of a wide range of global optimization algorithms described as a set of interacting operations. At one extreme, MANGO welcomes an individual non-cooperating agent, which is basically the traditional way of solving a global optimization problem. At the other extreme, autonomous agents existing in the environment cooperate as they see fit during run time. We explain the development and communication tools provided in the environment as well as examples of agent realizations and cooperation scenarios. We also show how the multiagent structure is more effective than having a single nonlinear optimization algorithm with randomly selected initial points. 相似文献
65.
In this work, we propose a scheme to realize a joint remote preparation of an arbitrary three-qubit state using six EPR-type pairs as the shared quantum resource. By determining the right measurement bases for the preparers and right ancilla-assisted unitary transformation/recovery operations for the receiver, our scheme applies to the most general case when all the coefficients of the state to be prepared and the EPR-type pairs are complex. The total success probability is found to be dependent only on the “smaller” coefficients of the EPR-type pairs shared between the receiver and one of the preparers. 相似文献
66.
Metin Başarır Selma Altundağ Mustafa Kayıkçı 《Rendiconti del Circolo Matematico di Palermo》2010,59(2):277-287
The purpose of the paper is to introduce the concepts of almost λ-statistical convergence and strongly almost λ-convergence of sequences of fuzzy numbers. We establish some connections between these concepts. It is also shown that if
a sequence of fuzzy numbers is strongly almost λ-convergent with respect to a sequence of Orlicz funtions then it is almost λ-statistical convergent. 相似文献
67.
Chord length distributions interpretation using a polydispersed population: Modeling and experiments
A. Cameirao H. Le Ba M. Darbouret J.-M. Herri J.-L. Peytavy P. Glénat 《Journal of Crystal Growth》2012,342(1):65-71
Chord length distributions were measured during the crystallization of gas hydrates in a flow loop. The conditions on the flow loop were similar with the conditions in the marine pipelines. The flow loop was filled with water in oil emulsion and pressurized with methane (7 MPa) at low temperature (277 K). During crystallization water droplets crystallize and agglomerate. The CLD measures were interpreted in a preceding work [Le Ba et al., 2010] [1] by constructing random aggregates with known geometrical proprieties from a monodispersed population of droplets and calculating their CLD. Comparing calculated CLD with CLD from the experiment, the geometrical parameters: number of primary particles and fractal dimension of experimental aggregates are identified. However some differences remained between the experiment and the calculated CLD. In the present work the droplets population was considered polydispersed improving the comparison between the model and the experiment. 相似文献
68.
Dang van Ba 《Zeitschrift für Angewandte Mathematik und Physik (ZAMP)》1969,20(4):599-602
Résumé On essaie de trouver l'équation du mouvement de la barre de contrôle d'un réacteur en théorie ponctuelle à un groupe de neutrons retardés à partir des principes stochastiques. 相似文献
69.
J. Baštecká 《Czechoslovak Journal of Physics》1965,15(8):595-601
The stress components based on anisotropic elasticity are found for edge and screw dislocations in α-Fe. The method of Eshelby, Read and Shockley is used. 相似文献
70.
The mathematics of Lorentz transformations, called the Lorentz group, continues to play an important role in optical sciences. It is the basic mathematical language for coherent and squeezed states. It is noted that the six-parameter Lorentz group can be represented by two-by-two matrices. Since the beam transfer matrices in ray optics are largely based on two-by-two matrices or ABCD matrices, the Lorentz group is bound to be the basic language for ray optics, including polarization optics, interferometers, lens optics, multilayer optics, and the Poincaré sphere. Because the group of Lorentz transformations and ray optics are based on the same two-by-two matrix formalism, ray optics can perform mathematical operations that correspond to transformations in special relativity. It is shown, in particular, that one-lens optics provides a mathematical basis for unifying the internal space-time symmetries of massive and massless particles in the Lorentz-covariant world. 相似文献