Accuracy of the Renormalization Method for Computing Effective Conductivities of Heterogeneous Media

The accuracy of the renormalization method for upscaling two-dimensional hydraulic conductivity fields is investigated, using two canonical 2 × 2 blocks: a checkerboard geometry and a geometry in which three of the cells have conductivity K ₁ and the other has conductivity K ₂. The predictions of the renormalization algorithm are compared to the arithmetic, harmonic and geometric means, as well as to theoretical predictions and finite element calculations. For the latter geometry renormalization works well over the entire range of the conductivity ratio K ₂/K ₁, but for the checkerboard geometry the error becomes unbounded as the conductivity ratio grows.     

Energetic switch of the proline effect in collision‐induced dissociation of singly and doubly protonated peptide Ala‐Ala‐Arg‐Pro‐Ala‐Ala

Suppression of the selective cleavage at N‐terminal of proline is observed in the peptide cleavage by proteolytic enzyme trypsin and in the fragment ion mass spectra of peptides containing Arg‐Pro sequence. An insight into the fragmentation mechanism of the influence of arginine residue on the proline effect can help in prediction of mass spectra and in protein structure analysis. In this work, collision‐induced dissociation spectra of singly and doubly charged peptide AARPAA were studied by ESI MS/MS and theoretical calculation methods. The proline effect was evaluated by comparing the experimental ratio of fragments originated from cleavage of different amide bonds. The results revealed that the backbone amide bond cleavage was selected by the energy barrier height of the fragmentation pathway although the strong proton affinity of the Arg side chain affected the stereostructure of the peptide and the dissociation mechanism. The thermodynamic stability of the fragment ions played a secondary role in the abundance ratio of fragments generated via different pathways. Fragmentation studies of protonated peptide AACitPAA supported the energy‐dependent hypothesis. The results provide an explanation to the long‐term arguments between the steric conflict and the proton mobility mechanisms of proline effect.     

Enhanced Electroreduction of Carbon Dioxide to Methanol Using Zinc Dendrites Pulse‐Deposited on Silver Foam

The electrocatalytic CO₂ reduction reaction (CO₂RR) can dynamise the carbon cycle by lowering anthropogenic CO₂ emissions and sustainably producing valuable fuels and chemical feedstocks. Methanol is arguably the most desirable C₁ product of CO₂RR, although it typically forms in negligible amounts. In our search for efficient methanol‐producing CO₂RR catalysts, we have engineered Ag‐Zn catalysts by pulse‐depositing Zn dendrites onto Ag foams (PD‐Zn/Ag foam). By themselves, Zn and Ag cannot effectively reduce CO₂ to CH₃OH, while their alloys produce CH₃OH with Faradaic efficiencies of approximately 1 %. Interestingly, with nanostructuring PD‐Zn/Ag foam reduces CO₂ to CH₃OH with Faradaic efficiency and current density values reaching as high as 10.5 % and ?2.7 mA cm^?2, respectively. Control experiments and DFT calculations pinpoint strained undercoordinated Zn atoms as the active sites for CO₂RR to CH₃OH in a reaction pathway mediated by adsorbed CO and formaldehyde. Surprisingly, the stability of the *CHO intermediate does not influence the activity.     

A radioxenon detection system using PIPS and CZT

Journal of Radioanalytical and Nuclear Chemistry - This paper introduces and describes the initial characterizations of a prototype beta-gamma coincidence detection system that utilizes a PIPSBox...     

Aerodynamic forces and flow fields of a two-dimensional hovering wing

This paper reports the results of an experimental investigation on a two-dimensional (2-D) wing undergoing symmetric simple harmonic flapping motion. The purpose of this investigation is to study how flapping frequency (or Reynolds number) and angular amplitude affect aerodynamic force generation and the associated flow field during flapping for Reynolds number (Re) ranging from 663 to 2652, and angular amplitudes (α _A) of 30°, 45° and 60°. Our results support the findings of earlier studies that fluid inertia and leading edge vortices play dominant roles in the generation of aerodynamic forces. More importantly, time-resolved force coefficients during flapping are found to be more sensitive to changes in α _A than in Re. In fact, a subtle change in α _A may lead to considerable changes in the lift and drag coefficients, and there appears to be an optimal mean lift coefficient around α _A = 45°, at least for the range of flow parameters considered here. This optimal condition coincides with the development a reverse Karman Vortex street in the wake, which has a higher jet stream than a vortex dipole at α _A = 30° and a neutral wake structure at α _A = 60°. Although Re has less effect on temporal force coefficients and the associated wake structures, increasing Re tends to equalize mean lift coefficients (and also mean drag coefficients) during downstroke and upstroke, thus suggesting an increasing symmetry in the mean force generation between these strokes. Although the current study deals with a 2-D hovering motion only, the unique force characteristics observed here, particularly their strong dependence on α _A, may also occur in a three-dimensional hovering motion, and flying insects may well have taken advantage of these characteristics to help them to stay aloft and maneuver. An erratum to this article can be found at     

Superposition of Spatially Interacting Aggregated Continuous Time Markov Chains

A system s{ X(t)} = {X ₁(t),X ₂(t),..., X _N(t)} of N interacting time reversible continuous time Markov chains is considered. The state space of each of the processes {X _i(t)} (i = 1, 2,...,N) is partitioned into two aggregates. Interaction between the processes {X _i(t)},{X ₂(t)},...,{X _N(t)} is introduced by allowing the transition rates of an individual process at time t to depend on the configuration of aggregates occupied by the other N - 1 processes at that time. The motivation for this work comes from ion channel modeling, where {(X}(t)} describes the gating mechanisms of N channels and the partitioning of the state space of {X _i(t)} correspond to whether the channel is conducting or not. Let S(t) denote the number of conducting channels at time t. For a time-reversible class of such processes, expressions are derived for the mean and probability density function of the sojourns of {S(t)} at its different levels when {X(t)} is in equilibrium. Particular attention is paid to the situation when the N channels are located on a circle with nearest neighbor interaction. Necessary and sufficient conditions for a general co-operative multiple channel system to be time reversible are derived.     

Internal transitions of two-dimensional charged magneto-excitons X: theory and experiment

Internal spin-singlet and spin-triplet transitions of charged excitons X⁻ in magnetic fields in quantum wells have been studied experimentally and theoretically. The allowed X⁻ transitions are photoionizing and exhibit a characteristic double-peak structure, which reflects the rich structure of the magnetoexciton continua in higher Landau levels (LLs). We discuss a novel exact selection rule, a hidden manifestation of translational invariance, that governs transitions of charged mobile complexes in a magnetic field.     

New pregnane glycosides from Cynanchum ascyrifolium

Two new pregnane glycosides, cynascyrosides D and E, were isolated from the roots of Cynanchum ascyrifolium. The structures of these compounds were determined on the basis of spectroscopic and chemical evidence as cynajapogenin A 3-O-alpha-L-cymaropyranosyl-(1-->4)-beta-D-digitoxopyranosyl-(1-->4)-beta-L-cymaropyranoside and cynajapogenin A 3-O-beta-D-glucopyranosyl-(1-->4)-alpha-L-diginopyranosyl-(1-->4)-beta-L-cymaropyranosyl-(1-->4)-beta-D-digitoxopyranoside.     

Decomposing <Emphasis Type="Italic">k</Emphasis>-ARc-Strong Tournaments Into Strong Spanning Subdigraphs

  The so-called Kelly conjecture states that every regular tournament on 2k+1 vertices has a decomposition into k-arc-disjoint hamiltonian cycles. In this paper we formulate a generalization of that conjecture, namely we conjecture that every k-arc-strong tournament contains k arc-disjoint spanning strong subdigraphs. We prove several results which support the conjecture:If D = (V, A) is a 2-arc-strong semicomplete digraph then it contains 2 arc-disjoint spanning strong subdigraphs except for one digraph on 4 vertices.Every tournament which has a non-trivial cut (both sides containing at least 2 vertices) with precisely k arcs in one direction contains k arc-disjoint spanning strong subdigraphs. In fact this result holds even for semicomplete digraphs with one exception on 4 vertices.Every k-arc-strong tournament with minimum in- and out-degree at least 37k contains k arc-disjoint spanning subdigraphs H ₁, H ₂, . . . , H _k such that each H _i is strongly connected.The last result implies that if T is a 74k-arc-strong tournament with speci.ed not necessarily distinct vertices u ₁, u ₂, . . . , u _k , v ₁, v ₂, . . . , v _k then T contains 2k arc-disjoint branchings where is an in-branching rooted at the vertex u _i and is an out-branching rooted at the vertex v _i , i=1,2, . . . , k. This solves a conjecture of Bang-Jensen and Gutin [3].We also discuss related problems and conjectures.

Chemical approaches for live cell bioimaging

We review various advancements in small molecule probes, intein-based labeling methods, and the incorporation of synthetic amino acids into proteins for live cell imaging experiments. Finally, recent developments in quantum dots-based labeling are briefly reviewed.