Correction to: Monte Carlo Simulation of the Efficiency of Fluorescence Resonance Energy Transfer,FRET Phenomenon

Journal of Fluorescence -     

Synthesis of functionalized dioxa-aza[7]helicenes using palladium catalyzed arylations

Despite the recent reports on transition-metal catalyzed cycloisomerization strategies toward helicenes, the amount of palladium catalyzed routes remains rather scarce. Within this letter the successful preparation and characterization of novel dioxa-aza[7]helicenes using palladium mediated coupling reactions is presented.     

Chelating DTPA amphiphiles: ion-tunable self-assembly structures and gadolinium complexes

A series of chelating amphiphiles and their gadolinium (Gd(iii)) metal complexes have been synthesized and studied with respect to their neat and lyotropic liquid crystalline phase behavior. These amphiphiles have the ability to form ion-tunable self-assembly nanostructures and their associated Gd(III) complexes have potential as magnetic resonance imaging (MRI) contrast enhancement agents. The amphiphiles are composed of diethylenetriaminepentaacetic acid (DTPA) chelates conjugated to one or two oleyl chain(s) (DTPA-MO and DTPA-BO), or isoprenoid-type chain(s) of phytanyl (DTPA-MP and DTPA-BP). The thermal phase behavior of the neat amphiphiles was examined by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and cross polarizing optical microscopy (POM). Self-assembly of neat amphiphiles and their associated Gd complexes, as well as their lyotropic phase behavior in water and sodium acetate solutions of different ionic strengths, were examined by POM and small and wide angle X-ray scattering (SWAXS). All neat amphiphiles exhibited lamellar structures. The non-complexed amphiphiles showed a variety of lyotropic phases depending on the number and nature of the hydrophobic chain in addition to the ionic state of the hydration. Upon hydration with increased Na-acetate concentration and the subtle changes in the effective headgroup size, the interfacial curvature of the amphiphile increased, altering the lyotropic liquid crystalline structures towards higher order mesophases such as the gyroid (Ia3d) bicontinuous cubic phase. The chelation of Gd with the DTPA amphiphiles resulted in lamellar crystalline structures for all the neat amphiphiles. Upon hydration with water, the Gd-complexed mono-conjugates formed micellar or vesicular self-assemblies, whilst the bis-conjugates transformed only partially into lyotropic liquid crystalline mesophases.     

Biotinylated chitosan-based SPIONs with potential in blood-contacting applications

Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300–700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field–assisted separations within biological systems.     

Experimental investigation and thermodynamic modeling of the Au–Ge–Ni system

Abstract  

Phase equilibria in the Au–Ge–Ni ternary system were studied by means of scanning electron microscopy, electron probe microanalysis, X-ray diffraction, and differential scanning calorimetry. The phase relations in the solid state at 600 °C as well as a vertical section at Au₇₂Ge₂₈–Ni were established. No ternary compound was found at 600 °C. On the basis of the experimental phase equilibria data, a thermodynamic model of the Au–Ge–Ni ternary system was developed using the CALPHAD method. Thermodynamically calculated phase diagrams are shown at 600 °C, in two vertical sections and the liquidus projection. Reasonable agreement between the calculations and the experimental results was achieved.     

Interactions between imazethapyr and bovine serum albumin: Spectrofluorimetric study

The interaction between imazethapyr (IMA) and bovine serum albumin (BSA) was investigated by fluorescence spectroscopy. The Stern–Volmer quenching constant (K_SV) at three temperatures was evaluated in order to determine the quenching mechanism. The dependence of fluorescence quenching on viscosity was also evaluated for this purpose. The results showed that IMA quenches the fluorescence intensity of BSA through a static quenching process. The values of the binding constant for the formed BSA–IMA complex and the number of binding sites were found to be 1.51×10⁵ M^?1 and 0.77, respectively, at room temperature. Based on the calculated thermodynamic parameters, the forces that dominate the binding process are hydrogen bonds and van der Waals forces, and the binding process is spontaneous and exothermic. The quenching of protein fluorescence by iodide ion was used to probe the accessibility of tryptophan residues in BSA and the change in accessibility induced by the presence of IMA. According to the obtained results, the BSA–IMA complex is formed in the site where the Trp-134 is located, causing it to become less exposed to the solvent.     

An integrated chemical biology approach provides insight into cdk2 functional redundancy and inhibitor sensitivity

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Highlights? Demonstration that Cdk2 is rate-limiting for DNA replication due to insufficient Cdk1 activity ? A simple bioinformatic approach to design inhibitor resistant mutations in kinases ? Demonstration of distinct binding modes and selectivity of Cdk inhibitors ? Identification of kinetic and structural mechanisms of inhibitor resistance     

A comparative study of the dimers of selected hydroxybenzenes

Hydroxybenzenes are the parent compounds of large classes of derivatives, many of which exhibit biological activities. This work presents the results of a comparative study of the dimers of selected hydroxybenzenes, considering all the possible mutual geometrical arrangements of the two monomers and comparing their relative stabilities and interaction energies. The OH···OH hydrogen bond between the two monomers is the dominant stabilizing factor, with frequent preference for mutual perpendicularity of the two aromatic rings. C? H···O unconventional H‐bonds, OH···π unconventional H‐bonds, H···π interactions and π··π interactions also may play significant roles. The factors stabilizing individual hydroxybenzenes (presence of intramolecular hydrogen bonds; number, positioning and orientation of the OH groups; symmetry features) have greater influence on the dimers' relative energy than on the interaction energy between monomers. While results from different calculations methods (HF, MP2, and DFT/B3LYP) show consistency for all the features just‐mentioned, they show some relevant differences in the way they take into account different types of interactions between monomers, resulting in some differences in the geometry arrangements of the monomers in the lowest energy dimers and in differences in the relative preferences among higher‐energy dimer geometries. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2012     

Hankel operators in Schatten ideals

We study membership to Schatten ideals S _E , associated with a monotone Riesz–Fischer space E, for the Hankel operators H _f defined on the Hardy space H ²(∂D). The conditions are expressed in terms of regularity of its symbol: we prove that H _f ∈S _E if and only if f∈B _E , the Besov space associated with a monotone Riesz–Fischer space E(dλ) over the measure space (D,dλ) and the main tool is the interpolation of operators. Received: December 17, 1999; in final form: September 25, 2000?Published online: July 13, 2001     

UNILATERAL EIGENVALUE PROBLEMS FOR NONLINEARLY ELASTIC PLATES： AN APPROACH VIA PSEUDO-MONOTONE OPERATORS

gi.TheTOpologicalDegreeforGeneralizedMonotoneOperatorsMonotoneoperatortheoryisoftenanefficienttoolforprovingtheexistenceofsolutionstononlinearProblems.Inparticular,thepseudo-monotoneoperatorsintroducedbyBrezis[2]areveryusefulforstudyingnonlinearellipticproblems.Weconsiderherethefollowingclassesofmappingsofgeneralizedmonotonetype.(QM)=theclassofquasi-mollotoneoperators,(S )=theclassofoperatorsoftype(S ),(PM)=theclassofpseudthmonotoneoperators,(LS)=theclassofLeray-Schauderoperators(compac…